CAS 19171-19-8

Pomalidomide

Descrizione:

Pomalidomide è un farmaco immunomodulatore utilizzato principalmente nel trattamento del mieloma multiplo e di alcune altre neoplasie ematologiche. Appartiene a una classe di composti noti come analoghi della talidomide, che esercitano i loro effetti attraverso vari meccanismi, inclusa la modulazione del sistema immunitario e l'inibizione della crescita tumorale. La formula chimica di Pomalidomide è C13H11N3O4S e presenta una struttura unica che include un anello ftalimidico, un gruppo sulfonamide e una catena laterale aromatica. Pomalidomide è noto per la sua capacità di migliorare l'attività delle cellule T e delle cellule natural killer, così come per le sue proprietà antiangiogeniche, che aiutano a inibire la formazione di nuovi vasi sanguigni di cui i tumori hanno bisogno per crescere. Il farmaco viene tipicamente somministrato per via orale e ha una emivita relativamente lunga, consentendo schemi di dosaggio convenienti. Tuttavia, è associato a potenziali effetti collaterali, comprese le tossicità ematologiche, e richiede un attento monitoraggio durante il trattamento. Nel complesso, Pomalidomide rappresenta un significativo progresso nelle terapie mirate contro il cancro.

Formula: C₁₃H₁₁N₃O₄

InChI: InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)

InChI key: InChIKey=UVSMNLNDYGZFPF-UHFFFAOYSA-N

SMILES: O=C1N(C(=O)C=2C1=CC=CC2N)C3C(=O)NC(=O)CC3

Sinonimi:

• 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-
• 2-(2,6-Dioxopiperidin-3-yl)-4-amino-isoindole-1,3-dione
• 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide
• 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
• 4-Amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione
• 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
• 4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
• 4-Amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione
• 4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
• Actimid
• Cc 4047
• Imnovid
• Phthalimide, 3-amino-N-(2,6-dioxo-3-piperidyl)-

Pomalidomide

CAS: 19171-19-8

Formula: C₁₃H₁₁N₃O₄

Purezza: >98.0%(HPLC)

Colore e forma: White to Yellow to Green powder to crystaline

Peso molecolare: 273.25

Ref: 3B-P2074

4-amino-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

CAS: 19171-19-8

Formula: C₁₃H₁₁N₃O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 273.2441

Ref: IN-DA002FFT

Pomalidomide

CAS: 19171-19-8

Pomalidomide

Purezza: 98%

Peso molecolare: 273.24g/mol

Ref: 54-BIPC1018

Pomalidomide

CAS: 19171-19-8

Formula: C₁₃H₁₁N₃O₄

Colore e forma: Yellow Solid

Peso molecolare: 273.25

Ref: 4Z-P-178001

Pomalidomide

CAS: 19171-19-8

Pomalidomide

Purezza: ≥98%

Peso molecolare: 273.24g/mol

Ref: 54-BUP17160

Pomalidomide

CAS: 19171-19-8

Colore e forma: Neat

Ref: 86-MM3919.00

Pomalidomide

CAS: 19171-19-8

Pomalidomide (CC-4047) is an anti-angiogenic and immunomodulatory agent. Pomalidomide is a ligand for CRBN. Cost-effective and quality-assured.

Formula: C₁₃H₁₁N₃O₄

Purezza: 98.8% - >99.99%

Colore e forma: Solid

Peso molecolare: 273.24

Ref: TM-T2384

Pomalidomide-d4

CAS: 19171-19-8

Formula: C₁₃H₇N₃O₄D₄

Colore e forma: White To Off-White Solid

Peso molecolare: 277.27

Ref: 4Z-P-178012

Pomalidomide

CAS: 19171-19-8

Formula: C₁₃H₁₁N₃O₄

Purezza: ≥ 98.5%

Colore e forma: Yellow to green powder

Peso molecolare: 273.24

Ref: 7W-GP0062

Pomalidomide

CAS: 19171-19-8

Applications Pomalidomide is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)

Formula: C₁₃H₁₁N₃O₄

Colore e forma: Yellow

Peso molecolare: 273.24

Ref: TR-P688200

Pomalidomide-d5

Prodotto controllato

CAS: 19171-19-8

Applications Pomalidomide-d5 is the labeled analogue of Pomalidomide (P688200), a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)

Formula: C₁₃D₅H₆N₃O₄

Colore e forma: Neat

Peso molecolare: 278.27

Ref: TR-P688203

Pomalidomide - Bio-X ™

Prodotto controllato

CAS: 19171-19-8

Pomalidomide is an immunomodulatory agent that inhibits transcriptional regulation by interacting with the pomalidomide-binding protein, which prevents its interaction with RNA polymerase II and thereby prevents DNA transcription. The study with U266 cells demonstrated that pomalidomide targets CRBN, part of an E3 ligase complex, and inhibits its autoubiquinitation and supresses a critical gene (IRF4, interferon regulatory factor 4) for myeloma cell growth with concentrations up to 10 μM. In vitro assays have shown that pomalidomide has inhibitory effects on cell signaling pathways, such as the NF-κB pathway. Pomalidomide also decreases the production of proinflammatory cytokines, such as TNFα and IL-1β, by inhibiting their synthesis or their release from activated monocytes. Recently, the promoting effect of pomalidomide, as its analog lenalidomide, on erythropoiesis (production of red blood cells) has been investigated, demonstrating positive results for its use as a potential new therapy agent for β-hemoglobinopathies.
Pomalidomide is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₃H₁₁N₃O₄

Purezza: Min. 99 Area-%

Colore e forma: Powder

Peso molecolare: 273.24 g/mol

Ref: 3D-BP164278

Pomalidomide

Prodotto controllato

CAS: 19171-19-8

Pomalidomide is an immunomodulatory agent that inhibits transcriptional regulation by interacting with the pomalidomide-binding protein, which prevents its interaction with RNA polymerase II and thereby prevents DNA transcription. The study with U266 cells demonstrated that pomalidomide targets CRBN, part of an E3 ligase complex, and inhibits its autoubiquinitation and supresses a critical gene (IRF4, interferon regulatory factor 4) for myeloma cell growth with concentrations up to 10 μM.In vitro assays have shown that pomalidomide has inhibitory effects on cell signaling pathways, such as the NF-κB pathway. Pomalidomide also decreases the production of proinflammatory cytokines, such as TNFα and IL-1β, by inhibiting their synthesis or their release from activated monocytes. Recently, the promoting effect of pomalidomide, as its analog lenalidomide, on erythropoiesis (production of red blood cells) has been investigated, demonstrating positive results for its use as a potential new therapy agent for β-hemoglobinopathies.

Formula: C₁₃H₁₁N₃O₄

Purezza: Min. 98 Area-%

Colore e forma: Yellow Powder

Peso molecolare: 273.24 g/mol

Ref: 3D-FA30210

4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

CAS: 19171-19-8

Formula: C₁₃H₁₁N₃O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 273.248

Ref: 10-F230365

Pomalidomide-d2 (Major)

Prodotto controllato

CAS: 19171-19-8

Formula: C₁₃D₂H₉N₃O₄

Colore e forma: Neat

Peso molecolare: 275.26

Ref: TR-P688207