CAS 19171-19-8
:Pomalidomide
Descrizione:
Pomalidomide è un farmaco immunomodulatore utilizzato principalmente nel trattamento del mieloma multiplo e di alcune altre neoplasie ematologiche. Appartiene a una classe di composti noti come analoghi della talidomide, che esercitano i loro effetti attraverso vari meccanismi, inclusa la modulazione del sistema immunitario e l'inibizione della crescita tumorale. La formula chimica di Pomalidomide è C13H11N3O4S e presenta una struttura unica che include un anello ftalimidico, un gruppo sulfonamide e una catena laterale aromatica. Pomalidomide è noto per la sua capacità di migliorare l'attività delle cellule T e delle cellule natural killer, così come per le sue proprietà antiangiogeniche, che aiutano a inibire la formazione di nuovi vasi sanguigni di cui i tumori hanno bisogno per crescere. Il farmaco viene tipicamente somministrato per via orale e ha una emivita relativamente lunga, consentendo schemi di dosaggio convenienti. Tuttavia, è associato a potenziali effetti collaterali, comprese le tossicità ematologiche, e richiede un attento monitoraggio durante il trattamento. Nel complesso, Pomalidomide rappresenta un significativo progresso nelle terapie mirate contro il cancro.
Formula:C13H11N3O4
InChI:InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
InChI key:InChIKey=UVSMNLNDYGZFPF-UHFFFAOYSA-N
SMILES:O=C1N(C(=O)C=2C1=CC=CC2N)C3C(=O)NC(=O)CC3
Sinonimi:- 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-
- 2-(2,6-Dioxopiperidin-3-yl)-4-amino-isoindole-1,3-dione
- 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide
- 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
- 4-Amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione
- 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
- 4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- 4-Amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione
- 4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
- Actimid
- Cc 4047
- Imnovid
- Phthalimide, 3-amino-N-(2,6-dioxo-3-piperidyl)-
- Vedi altri sinonimi
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15 prodotti.
Pomalidomide
CAS:Formula:C13H11N3O4Purezza:>98.0%(HPLC)Colore e forma:White to Yellow to Green powder to crystalinePeso molecolare:273.254-amino-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS:Formula:C13H11N3O4Purezza:98%Colore e forma:SolidPeso molecolare:273.2441Pomalidomide
CAS:Pomalidomide (CC-4047) is an anti-angiogenic and immunomodulatory agent. Pomalidomide is a ligand for CRBN. Cost-effective and quality-assured.Formula:C13H11N3O4Purezza:98.8% - >99.99%Colore e forma:SolidPeso molecolare:273.24Ref: 4Z-P-178012
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaPomalidomide
CAS:Formula:C13H11N3O4Purezza:≥ 98.5%Colore e forma:Yellow to green powderPeso molecolare:273.24Pomalidomide
CAS:Applications Pomalidomide is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)Formula:C13H11N3O4Colore e forma:YellowPeso molecolare:273.24Pomalidomide - Bio-X ™
CAS:Prodotto controllatoPomalidomide is an immunomodulatory agent that inhibits transcriptional regulation by interacting with the pomalidomide-binding protein, which prevents its interaction with RNA polymerase II and thereby prevents DNA transcription. The study with U266 cells demonstrated that pomalidomide targets CRBN, part of an E3 ligase complex, and inhibits its autoubiquinitation and supresses a critical gene (IRF4, interferon regulatory factor 4) for myeloma cell growth with concentrations up to 10 μM. In vitro assays have shown that pomalidomide has inhibitory effects on cell signaling pathways, such as the NF-κB pathway. Pomalidomide also decreases the production of proinflammatory cytokines, such as TNFα and IL-1β, by inhibiting their synthesis or their release from activated monocytes. Recently, the promoting effect of pomalidomide, as its analog lenalidomide, on erythropoiesis (production of red blood cells) has been investigated, demonstrating positive results for its use as a potential new therapy agent for β-hemoglobinopathies. Pomalidomide is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C13H11N3O4Purezza:Min. 99 Area-%Colore e forma:PowderPeso molecolare:273.24 g/molPomalidomide
CAS:Prodotto controllatoPomalidomide is an immunomodulatory agent that inhibits transcriptional regulation by interacting with the pomalidomide-binding protein, which prevents its interaction with RNA polymerase II and thereby prevents DNA transcription. The study with U266 cells demonstrated that pomalidomide targets CRBN, part of an E3 ligase complex, and inhibits its autoubiquinitation and supresses a critical gene (IRF4, interferon regulatory factor 4) for myeloma cell growth with concentrations up to 10 μM.In vitro assays have shown that pomalidomide has inhibitory effects on cell signaling pathways, such as the NF-κB pathway. Pomalidomide also decreases the production of proinflammatory cytokines, such as TNFα and IL-1β, by inhibiting their synthesis or their release from activated monocytes. Recently, the promoting effect of pomalidomide, as its analog lenalidomide, on erythropoiesis (production of red blood cells) has been investigated, demonstrating positive results for its use as a potential new therapy agent for β-hemoglobinopathies.Formula:C13H11N3O4Purezza:Min. 98 Area-%Colore e forma:Yellow PowderPeso molecolare:273.24 g/mol4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS:Formula:C13H11N3O4Purezza:98%Colore e forma:SolidPeso molecolare:273.248Pomalidomide-d5
CAS:Prodotto controllatoApplications Pomalidomide-d5 is the labeled analogue of Pomalidomide (P688200), a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)Formula:C13D5H6N3O4Colore e forma:NeatPeso molecolare:278.27Pomalidomide-d2 (Major)
CAS:Prodotto controllatoFormula:C13D2H9N3O4Colore e forma:NeatPeso molecolare:275.26
