CAS 19186-35-7

(5R,5aR,8aR)-5-(3,4,5-trimetossifenile)-5,8,8a,9-tetraidrofuro[3',4':6,7]nafto[2,3-d][1,3]diossol-6(5aH)-one

Descrizione:

La sostanza chimica con il nome "(5R,5aR,8aR)-5-(3,4,5-trimetossifenile)-5,8,8a,9-tetraidrofuro[3',4':6,7]nafto[2,3-d][1,3]diossol-6(5aH)-one" e numero CAS "19186-35-7" è un composto organico complesso caratterizzato dalla sua intricatissima struttura policiclica, che include un nucleo di naftalene fuso con un dioxolo e un moiety di tetraidrofurano. Questo composto presenta più gruppi metossilici, noti per migliorare la solubilità e influenzare l'attività biologica. La stereochimica indicata dalle configurazioni R suggerisce specifici arrangiamenti spaziali che possono influenzare significativamente la reattività del composto e le sue interazioni con obiettivi biologici. Tali composti spesso mostrano interessanti proprietà farmacologiche, rendendoli oggetto di interesse nella chimica medicinale. Inoltre, la presenza di più gruppi funzionali può portare a una reattività chimica diversificata, consentendo modifiche potenziali che potrebbero migliorare l'efficacia terapeutica o ridurre la tossicità. In generale, questo composto esemplifica la complessità e la diversità presenti nella chimica organica, in particolare nel campo della sintesi di prodotti naturali e dello sviluppo di farmaci.

Formula: C₂₂H₂₂O₇

InChI: InChI=1/C22H22O7/c1-24-17-6-12(7-18(25-2)21(17)26-3)19-14-8-16-15(28-10-29-16)5-11(14)4-13-9-27-22(23)20(13)19/h5-8,13,19-20H,4,9-10H2,1-3H3/t13-,19+,20-/m0/s1

InChI key: InChIKey=ZGLXUQQMLLIKAN-SVIJTADQSA-N

SMILES: O=C1[C@@]2([C@@H](C=3C(C[C@]2(CO1)[H])=CC4=C(C3)OCO4)C5=CC(OC)=C(OC)C(OC)=C5)[H]

Sinonimi:

• (-)-Anthricin
• (5R,5aR,8aR)-5,8,8a,9-Tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• 4-Deoxypodophyllotoxin
• As 2-3
• Deoxypodophyllotoxin
• Desoxypodophyllotoxin
• Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR)-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR)-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, [5R-(5α,5aβ,8aα)]-
• Podophyllotoxin, deoxy-
• Silicicolin
• Anthricin/Deoxypodophyllotoxin
• anthric
• Podophyllotoxin 9-Desoxy Impurity
• Deoxypodophyllotoxin, deoxypodophyllotoxin

(-)-Deoxypodophyllotoxin

CAS: 19186-35-7

Formula: C₂₂H₂₂O₇

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 398.4059

Ref: IN-DA002FHT

Deoxypodophyllotoxin

CAS: 19186-35-7

Deoxypodophyllotoxin

Purezza: ≥98%

Peso molecolare: 398.41g/mol

Ref: 54-BUP16322

Deoxypodophyllotoxin

CAS: 19186-35-7

Formula: C₂₂H₂₂O₇

Peso molecolare: 398.41

Ref: 7W-GY9442

Podophyllotoxin Impurity 5

CAS: 19186-35-7

Formula: C₂₂H₂₂O₇

Colore e forma: White To Off-White Solid

Peso molecolare: 398.41

Ref: 4Z-P-122005

Deoxypodophyllotoxin

CAS: 19186-35-7

Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities. Deoxypodophyllotoxin induces G2 /M cell-cycle arrest followed by apoptosis through multiple cellular processes, involving the activation of ATM, upregulation of p53 and Bax, activation of caspase-3 and -7, and accumulation of PTEN resulting in the inhibition of the Akt pathway. Deoxypodophyllotoxin maybe applicable to treat hyperpigmentation, it decreases UV-induced skin pigmentation of brown guinea pigs.

Formula: C₂₂H₂₂O₇

Purezza: 95%~99%

Peso molecolare: 398.41

Ref: BP-SBP02032

Deoxypodophyllotoxin

CAS: 19186-35-7

Deoxypodophyllotoxin is cytotoxic, antineoplastic, anti-tumor, anti-angiogenic, antiviral, and anti-inflammatory.

Formula: C₂₂H₂₂O₇

Purezza: 99.65% - 99.84%

Colore e forma: Solid

Peso molecolare: 398.41

Ref: TM-TN1087

4-Deoxypodophyllotoxin

CAS: 19186-35-7

4-Deoxypodophyllotoxin is a natural lignan, which is a type of secondary metabolite. It is primarily sourced from the roots and rhizomes of several plants belonging to the Podophyllum species, such as Podophyllum hexandrum. This compound exhibits its mode of action by interfering with microtubule assembly, thus disrupting cell division and leading to apoptotic cell death. Its effectiveness at halting mitosis makes it a subject of interest in cancer research.

Formula: C₂₂H₂₂O₇

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 398.41 g/mol

Ref: 3D-FD157413

4-Deoxypodophyllotoxin

Prodotto controllato

CAS: 19186-35-7

Applications 4-Deoxypodophyllotoxin is a medicinal herb product isolated from Anthriscus sylvestris Hoffm. It is well known for its antitumor, antiviral, and anti-inflammatory activities. 4-Deoxypodophyllotoxin was also shown to inhibit the passive cutaneous anaphylaxis reaction.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lin, C.X., et al.: Planta. Med., 70, 474 (2004); Peng, Xu., et al.: Neurotoxicol., 31, 680 (2010); Kim, Y., et al.: Planta, Med., 68, 271 (2002);

Formula: C₂₂H₂₂O₇

Colore e forma: Off-White

Peso molecolare: 398.41

Ref: TR-D249500