CAS 192725-17-0: Lopinavir

Descrizione: Lopinavir è un farmaco antiretrovirale utilizzato principalmente nel trattamento dell'HIV/AIDS. Appartiene alla classe degli inibitori della proteasi ed è spesso combinato con ritonavir per aumentarne l'efficacia e la biodisponibilità. La formula chimica di Lopinavir è C37H48N4O5 e ha un peso molecolare di circa 628,88 g/mol. Lopinavir è caratterizzato dalla sua struttura complessa, che include più anelli e gruppi funzionali che contribuiscono alla sua attività farmacologica. Viene tipicamente somministrato per via orale sotto forma di compresse o soluzione liquida. La sostanza è nota per la sua capacità di inibire l'enzima proteasi dell'HIV, impedendo così la replicazione virale. Lopinavir è generalmente ben tollerato, ma può avere effetti collaterali, tra cui disturbi gastrointestinali e potenziali impatti sul metabolismo lipidico. A causa del suo ruolo nel trattamento dell'HIV, Lopinavir è spesso parte di regimi di terapia combinata, che possono includere altri agenti antiretrovirali per migliorare i risultati del trattamento e ridurre il rischio di resistenza.

Formula: C₃₇H₄₈N₄O₅

InChI: InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1

InChI key: InChIKey=KJHKTHWMRKYKJE-SUGCFTRWSA-N

SMILES: O=C1NCCCN1C(C(=O)NC(CC=2C=CC=CC2)CC(O)C(NC(=O)COC=3C(=CC=CC3C)C)CC=4C=CC=CC4)C(C)C

Sinonimi:

• A 157378.0
• 1(2H)-Pyrimidineacetamide, N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-, (αS)-
• 1(2H)-Pyrimidineacetamide, N-[(1S,3S,4S)-4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-, (αS)-
• (αS)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide
• 1(2H)-Pyrimidineacetamide, N-[4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-, [1S-[1R*(R*),3R*,4R*]]-
• ABT 378
• ABT-378
• UNII-2494G1JF75
• Kaletra
• (S)-N-((2S,4S,5S)-5-(2-(2,6-dimethylphenoxy)acetamido)-4-hydroxy-1,6-diphenylhexan-2-yl)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
• (1S-(1R*(R*),3R*,4R*))-N-(4-(((2,6-Dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide
• (2S)-N-[(2S,4S,5S)-5-{[(2,6-dimethylphenoxy)acetyl]amino}-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
• 1(2H)-Pyrimidineacetamide, N-((1S,3S,4S)-4-(((2,6-dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahyrdo-alpha-1-methylethyl)-2-oxo-, (alphaS)-
• (alphaS)-Tetrahydro-N-((alphaS)-alpha-((2S,3S)-2-hydroxy-4-phenyl-3-(2-(2,6-xylyloxy)acetamido)butyl)phenethyl)-alpha-isopropyl-2-oxo-1(2H)-pyrimidineacetamide

Lopinavir

CAS: 192725-17-0

• Formula: C₃₇H₄₈N₄O₅
• Purezza: >98.0%(HPLC)
• Colore e forma: White to Light yellow powder to crystal
• Peso molecolare: 628.81

Lopinavir for peak identification CRS

CAS: 192725-17-0

• Formula: C₃₇H₄₈N₄O₅
• Peso molecolare: 628.8008

Lopinavir for system suitability CRS

CAS: 192725-17-0

• Formula: C₃₇H₄₈N₄O₅
• Peso molecolare: 628.8008

Lopinavir RS

CAS: 192725-17-0

Lopinavir CRS

CAS: 192725-17-0

Lopinavir

CAS: 192725-17-0

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

• Formula: C₃₇H₄₈N₄O₅
• Colore e forma: White Off-White Powder
• Peso molecolare: 628.36247

(αS)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide

CAS: 192725-17-0

• Formula: C₃₇H₄₈N₄O₅
• Purezza: %
• Colore e forma: Solid
• Peso molecolare: 628.8008

Lopinavir

CAS: 192725-17-0

• Formula: C₃₇H₄₈N₄O₅
• Colore e forma: Off-White Solid
• Peso molecolare: 628.81

Lopinavir EP Impurity H

CAS: 192725-17-0

• Formula: C₂₉H₃₂N₂O₄
• Colore e forma: White To Off-White Solid
• Peso molecolare: 472.59

Lopinavir

CAS: 192725-17-0

• Formula: C₃₇H₄₈N₄O₅
• Purezza: ≥ 98.0% (anhydrous basis)
• Colore e forma: White crystalline powder
• Peso molecolare: 628.80

Lopinavir, 98%

CAS: 192725-17-0

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₃₇H₄₈N₄O₅
• Purezza: 98%
• Colore e forma: White to beige, Powder
• Peso molecolare: 628.81

Lopinavir

CAS: 192725-17-0

• Formula: C₃₇H₄₈N₄O₅
• Colore e forma: Neat
• Peso molecolare: 628.80

Lopinavir

CAS: 192725-17-0

• Formula: C₃₇H₄₈N₄O₅
• Colore e forma: Neat
• Peso molecolare: 628.80

Lopinavir

CAS: 192725-17-0

Lopinavir (ABT-378) is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with …

• Formula: C₃₇H₄₈N₄O₅
• Purezza: 98% - 99.14%
• Colore e forma: White Crystalline Solid
• Peso molecolare: 628.8

Lopinavir

CAS: 192725-17-0

• Purezza: 95.0%
• Colore e forma: Liquid
• Peso molecolare: 628.8140258789062

Lopinavir

CAS: 192725-17-0

Stability Hygroscopic Applications A selective HIV protease inhibitor. An analogue of Ritonavir. Antiviral. It is …

• Formula: C₃₇H₄₈N₄O₅
• Colore e forma: White Solid
• Peso molecolare: 628.80

Lopinavir - Bio-X ™

CAS: 192725-17-0

Chemically derived from ritonavir, Lopinavir belongs to the amphetamines. Lopinavir is clinically used in the …

• Formula: C₃₇H₄₈N₄O₅
• Purezza: Min. 98 Area-%
• Colore e forma: Powder
• Peso molecolare: 628.8 g/mol

Lopinavir

CAS: 192725-17-0

Anti-viral; HIV protease inhibitor

• Formula: C₃₇H₄₈N₄O₅
• Purezza: Min. 97.5 Area-%
• Colore e forma: White Off-White Powder
• Peso molecolare: 628.8 g/mol

N5-Des[(2,6-dimethylphenoxy)acetyl] N5-Formal Lopinavir

CAS: 192725-17-0

• Formula: C₂₈H₃₈N₄O₄
• Colore e forma: Neat
• Peso molecolare: 494.63