CAS 192725-17-0

Lopinavir

Descrizione:

Lopinavir è un farmaco antiretrovirale utilizzato principalmente nel trattamento dell'HIV/AIDS. Appartiene alla classe degli inibitori della proteasi ed è spesso combinato con ritonavir per aumentarne l'efficacia e la biodisponibilità. La formula chimica di Lopinavir è C37H48N4O5 e ha un peso molecolare di circa 628,88 g/mol. Lopinavir è caratterizzato dalla sua struttura complessa, che include più anelli e gruppi funzionali che contribuiscono alla sua attività farmacologica. Viene tipicamente somministrato per via orale sotto forma di compresse o soluzione liquida. La sostanza è nota per la sua capacità di inibire l'enzima proteasi dell'HIV, impedendo così la replicazione virale. Lopinavir è generalmente ben tollerato, ma può avere effetti collaterali, tra cui disturbi gastrointestinali e potenziali impatti sul metabolismo lipidico. A causa del suo ruolo nel trattamento dell'HIV, Lopinavir è spesso parte di regimi di terapia combinata, che possono includere altri agenti antiretrovirali per migliorare i risultati del trattamento e ridurre il rischio di resistenza.

Formula: C₃₇H₄₈N₄O₅

InChI: InChI=1/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1

InChI key: InChIKey=KJHKTHWMRKYKJE-SUGCFTRWSA-N

SMILES: [C@@H](C(N[C@@H](CC1=CC=CC=C1)C[C@@H]([C@H](CC2=CC=CC=C2)NC(COC3=C(C)C=CC=C3C)=O)O)=O)([C@@H](C)C)N4C(=O)NCCC4

Sinonimi:

• A 157378.0
• 1(2H)-Pyrimidineacetamide, N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-, (αS)-
• 1(2H)-Pyrimidineacetamide, N-[(1S,3S,4S)-4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-, (αS)-
• (αS)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide
• 1(2H)-Pyrimidineacetamide, N-[4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-, [1S-[1R*(R*),3R*,4R*]]-
• ABT 378
• ABT-378
• UNII-2494G1JF75
• Kaletra
• (S)-N-((2S,4S,5S)-5-(2-(2,6-dimethylphenoxy)acetamido)-4-hydroxy-1,6-diphenylhexan-2-yl)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
• (1S-(1R*(R*),3R*,4R*))-N-(4-(((2,6-Dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide
• (2S)-N-[(2S,4S,5S)-5-{[(2,6-dimethylphenoxy)acetyl]amino}-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
• 1(2H)-Pyrimidineacetamide, N-((1S,3S,4S)-4-(((2,6-dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahyrdo-alpha-1-methylethyl)-2-oxo-, (alphaS)-
• (alphaS)-Tetrahydro-N-((alphaS)-alpha-((2S,3S)-2-hydroxy-4-phenyl-3-(2-(2,6-xylyloxy)acetamido)butyl)phenethyl)-alpha-isopropyl-2-oxo-1(2H)-pyrimidineacetamide
• LOPINAVIR
• Aluviran
• Koletra
• (2S)-N-[(2R,4S,5S)-5-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenyl-hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
• (2s)-n-[(2r,4s,5s)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenyl-hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
• (2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenyl-hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide

Lopinavir

CAS: 192725-17-0

Formula: C₃₇H₄₈N₄O₅

Purezza: >98.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 628.81

Ref: 3B-L0377

Lopinavir

CAS: 192725-17-0

Colore e forma: Neat

Ref: 61-FOR1151.00

LOPINAVIR FOR SYSTEM SUITABILITY CRS

CAS: 192725-17-0

LOPINAVIR FOR SYSTEM SUITABILITY CRS

Formula: C₃₇H₄₈N₄O₅

Peso molecolare: 628.8008

Ref: 41-Y0001505

LOPINAVIR FOR PEAK IDENTIFICATION CRS

CAS: 192725-17-0

LOPINAVIR FOR PEAK IDENTIFICATION CRS

Formula: C₃₇H₄₈N₄O₅

Peso molecolare: 628.8008

Ref: 41-Y0001506

LOPINAVIR CRS

CAS: 192725-17-0

LOPINAVIR CRS

Ref: 41-Y0001498

LOPINAVIR RS

CAS: 192725-17-0

LOPINAVIR RS

Ref: 41-ICRS60025

Lopinavir

CAS: 192725-17-0

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₃₇H₄₈N₄O₅

Colore e forma: White Off-White Powder

Peso molecolare: 628.36247

Ref: 45-1370101

(2S)-N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide

CAS: 192725-17-0

Formula: C₃₇H₄₈N₄O₅

Purezza: %

Colore e forma: Solid

Peso molecolare: 628.8008

Ref: IN-DA003RD4

Lopinavir

CAS: 192725-17-0

Lopinavir

Purezza: ≥98%

Peso molecolare: 628.8g/mol

Ref: 54-BUP14926

Lopinavir

CAS: 192725-17-0

Lopinavir

Purezza: 98%

Peso molecolare: 628.8g/mol

Ref: 54-OR1027378

Lopinavir

CAS: 192725-17-0

Formula: C₃₇H₄₈N₄O₅

Colore e forma: Off-White Solid

Peso molecolare: 628.81

Ref: 4Z-L-301

Lopinavir EP Impurity H

CAS: 192725-17-0

Formula: C₂₉H₃₂N₂O₄

Colore e forma: White To Off-White Solid

Peso molecolare: 472.58

Ref: 4Z-L-3017

Lopinavir

CAS: 192725-17-0

Formula: C₃₇H₄₈N₄O₅

Colore e forma: Neat

Peso molecolare: 628.80

Ref: 86-MM1151.00

Lopinavir

CAS: 192725-17-0

Formula: C₃₇H₄₈N₄O₅

Purezza: ≥ 98.0% (anhydrous basis)

Colore e forma: White crystalline powder

Peso molecolare: 628.80

Ref: 7W-GP6351

Lopinavir

CAS: 192725-17-0

Lopinavir (ABT-378) is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation.

Formula: C₃₇H₄₈N₄O₅

Purezza: 98% - 99.62%

Colore e forma: White Crystalline Solid

Peso molecolare: 628.8

Ref: TM-T1623

Lopinavir

CAS: 192725-17-0

Stability Hygroscopic
Applications A selective HIV protease inhibitor. An analogue of Ritonavir. Antiviral. It is a COVID19-related research product.
References Sham, H.L., et al.: Antimicrob. Ag. Chemother., 42, 3218 (1998), Kumar, G.N., et al.: Drug Metab. Dispos., 27, 86 (1999), Murphy, R.L., et al.: Antiviral Ther., 4, Suppl. 3, 85 (1999)

Formula: C₃₇H₄₈N₄O₅

Colore e forma: White Solid

Peso molecolare: 628.80

Ref: TR-L469480

Lopinavir

CAS: 192725-17-0

Anti-viral; HIV protease inhibitor

Formula: C₃₇H₄₈N₄O₅

Purezza: Min. 97.5 Area-%

Colore e forma: White Off-White Powder

Peso molecolare: 628.8 g/mol

Ref: 3D-FL16558

Lopinavir - Bio-X ™

CAS: 192725-17-0

Chemically derived from ritonavir, Lopinavir belongs to the amphetamines. Lopinavir is clinically used in the prevention and treatment of HIV infections as it acts as HIV-1 protease inhibitor. In 2020, lopinavir was tested to treat COVID-19 patients and although it led to a higher rate of gastrointestinal side effects, the Lopinavir-treated group had a lower incidence of severe complications. Overall it was deemed not to work as a treatment.

Formula: C₃₇H₄₈N₄O₅

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 628.8 g/mol

Ref: 3D-BL164636

N5-Des[(2,6-dimethylphenoxy)acetyl] N5-Formal Lopinavir

Prodotto controllato

CAS: 192725-17-0

Formula: C₂₈H₃₈N₄O₄

Colore e forma: Neat

Peso molecolare: 494.63

Ref: TR-D288205

Lopinavir

CAS: 192725-17-0

Purezza: 95.0%

Colore e forma: Liquid

Peso molecolare: 628.8140258789062

Ref: 10-F079428