CAS 193079-69-5

Tabimorelina

Descrizione:

Tabimorelina, con il numero CAS 193079-69-5, è un peptide sintetico che funge da secretagogo dell'ormone della crescita. Viene utilizzato principalmente in contesti di ricerca per stimolare il rilascio dell'ormone della crescita dalla ghiandola pituitaria. Tabimorelina agisce sul recettore della grelina, mimando l'azione della grelina, un ormone che gioca un ruolo cruciale nella regolazione dell'appetito e dell'equilibrio energetico. Questo composto è caratterizzato dalla sua capacità di aumentare i livelli di ormone della crescita, il che può avere implicazioni in diverse aree terapeutiche, tra cui la carenza di ormone della crescita e i disturbi metabolici. Tabimorelina viene tipicamente somministrato per iniezione ed è stato studiato per i suoi potenziali effetti sulla composizione corporea, sulla massa muscolare e sulla salute metabolica complessiva. La sua farmacocinetica e il profilo di sicurezza sono oggetto di ricerca continua e, sebbene mostri promesse, sono necessari ulteriori studi per comprendere appieno la sua efficacia e le potenziali applicazioni nella pratica clinica. Come per qualsiasi peptide, stabilità, condizioni di stoccaggio e corretta manipolazione sono essenziali per mantenere la sua integrità ed efficacia.

Formula: C₃₂H₄₀N₄O₃

InChI: InChI=1S/C32H40N4O3/c1-32(2,33)19-11-16-29(37)35(4)28(22-24-17-18-25-14-9-10-15-26(25)20-24)31(39)36(5)27(30(38)34-3)21-23-12-7-6-8-13-23/h6-18,20,27-28H,19,21-22,33H2,1-5H3,(H,34,38)/b16-11+/t27-,28-/m1/s1

InChI key: InChIKey=WURGZWOTGMLDJP-ZCYANPAGSA-N

SMILES: [C@@H](CC1=CC2=C(C=C1)C=CC=C2)(C(N([C@H](CC3=CC=CC=C3)C(NC)=O)C)=O)N(C(/C=C/CC(C)(C)N)=O)C

Sinonimi:

• (R)-alpha-((E)-5-Amino-N,5-dimethyl-2-hexenamido)-N-methyl-N-((R)-alpha-(methylcarbamoyl)phenethyl)-2-naphthalenepropionamide
• <span class="text-smallcaps">D</smallcap>-Phenylalaninamide, N-[(2E)-5-amino-5-methyl-1-oxo-2-hexen-1-yl]-N-methyl-3-(2-naphthalenyl)-<smallcap>D</span>-alanyl-N,N^α-dimethyl-
• <span class="text-smallcaps">D</smallcap>-Phenylalaninamide, N-[(2E)-5-amino-5-methyl-1-oxo-2-hexenyl]-N-methyl-3-(2-naphthalenyl)-<smallcap>D</span>-alanyl-N,N^α-dimethyl-
• N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexen-1-yl]-N-methyl-3-(2-naphthalenyl)-<span class="text-smallcaps">D</smallcap>-alanyl-N,N^α-dimethyl-<smallcap>D</span>-phenylalaninamide
• N-[(2E)-5-amino-5-methylhex-2-enoyl]-N-methyl-3-(naphthalen-2-yl)-D-alanyl-N,Nα-dimethyl-D-phenylalaninamide
• Nn 703
• Nnc 26-0703
• Tabimorelin [INN]
• Unii-L51Cbe03Kf
• N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexen-1-yl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-D-phenylalaninamide
• Tabimorelin
• D-Phenylalaninamide, N-[(2E)-5-amino-5-methyl-1-oxo-2-hexenyl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-
• D-Phenylalaninamide, N-[(2E)-5-amino-5-methyl-1-oxo-2-hexen-1-yl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-
• N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexenyl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-D-phenylalaninamidehemifumarate
• NNC26-0703
• N-[5-Amino-5-Methyl-2(E)-Hexenoyl]-N-Methyl-3-(2- Naphthyl)-D-Alanyl-N-Methyl-D-Phenylalanine Methylamide
• NNC-260703

Tabimorelin

CAS: 193079-69-5

Formula: C₃₂H₄₀N₄O₃

Peso molecolare: 528.70

Ref: 4Z-T-172001

Tabimorelin

Prodotto controllato

CAS: 193079-69-5

Applications NN703 (Tabimorelin) is an orally active growth hormone (GH) secretagogue intended for use as an alternative to daily injections of GH. In vitro studies in human liver microsomes have indicated that NN703 is a mechanism-based inhibitor of CYP3A4.
References Fabre, G., et al.: Biochem. Pharmacol., 37, 4389 (1988), Thummel, K., et al.: Clin. Pharmacol. Ther., 59, 491 (1996), Yu, D., et al.: J. Clin. Pharmacol., 39, 1203 (1999),

Formula: C₃₂H₄₀N₄O₃

Colore e forma: Neat

Peso molecolare: 528.68

Ref: TR-T003500

Tabimorelin

CAS: 193079-69-5

Tabimorelin is a potent analog of the endogenous hormone ghrelin. It binds to the ghrelin receptor and stimulates appetite, thereby increasing food intake and weight gain. Tabimorelin also has been shown to be effective in treating bowel disease, diabetic neuropathy, and symptoms of inflammatory bowel disease. The pharmacological effects of tabimorelin are due to its ability to bind to receptors in the gastrointestinal tract. This drug also has an effect on coordination complex formation by human liver microsomes. Tabimorelin can be used as a diagnostic tool for some types of cancer because it is not metabolized by enzymes in healthy cells, but is metabolized by enzymes in cancer cells. The use of tabimorelin as an analytical method is based on its ability to form coordination complexes with heavy metals such as mercury or lead.

Formula: C₆₈H₈₄N₈O₁₀

Purezza: Min. 95%

Peso molecolare: 1,173.4 g/mol

Ref: 3D-THA07969