CAS 1948273-03-7

L-Prolinamide, 3-metil-L-valil-4-idrossi-N-[(1S)-1-[4-(4-metil-5-tiazolil)fenil]etil]-, cloridrato (1:1), (4R)-

Descrizione:

L-Prolinamide, 3-metil-L-valile-4-idrossi-N-[(1S)-1-[4-(4-metil-5-tiazolil)fenile]etile]-, cloruro (1:1), con numero CAS 1948273-03-7, è un composto sintetico che appartiene alla classe dei derivati degli aminoacidi. Questa sostanza presenta una struttura complessa caratterizzata dalla presenza di un derivato della prolina, un gruppo tiazolico e un gruppo fenilico, che contribuiscono alla sua potenziale attività biologica. La forma cloridrato indica che si tratta di un sale, migliorando la sua solubilità in soluzioni acquose, il che è spesso vantaggioso per applicazioni farmacologiche. Il composto può presentare una stereochimica specifica, come indicato dalle designazioni (1S) e (4R), che possono influenzare la sua interazione con obiettivi biologici. La sua combinazione unica di gruppi funzionali suggerisce potenziali usi in chimica medicinale, in particolare nello sviluppo di farmaci. Tuttavia, sarebbero necessari studi dettagliati sulla sua farmacodinamica, farmacocinetica e tossicità per comprendere appieno le sue proprietà e potenziali applicazioni.

Formula: C₂₃H₃₂N₄O₃S·ClH

InChI: InChI=1S/C23H32N4O3S.ClH/c1-13(15-6-8-16(9-7-15)19-14(2)25-12-31-19)26-21(29)18-10-17(28)11-27(18)22(30)20(24)23(3,4)5;/h6-9,12-13,17-18,20,28H,10-11,24H2,1-5H3,(H,26,29);1H/t13-,17+,18-,20+;/m0./s1

InChI key: InChIKey=GHFOLQCCYGBOTL-QDVBFIRISA-N

SMILES: C([C@H](C(C)(C)C)N)(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1.Cl

Sinonimi:

• (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-[(S)-1-[4-(4-methylthiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide hydrochloride
• (2S,4R)-1-((2S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-[(1S)-1-[4-(4-methylthiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide monohydrochloride
• L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, hydrochloride (1:1), (4R)-
• (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride
• (2S,4R)-1-((2S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide hydrochloride

(S,R,S)-AHPC-Me hydrochloride

CAS: 1948273-03-7

(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein

Formula: C₂₃H₃₃ClN₄O₃S

Purezza: 99.18%

Colore e forma: Solid

Peso molecolare: 481.05

Ref: TM-T13671

(S,R,S)-AHPC-Me hydrochloride

CAS: 1948273-03-7

(S,R,S)-AHPC-Me hydrochloride

Purezza: ≥98%

Peso molecolare: 481.05g/mol

Ref: 54-BUP14166

(2S,4R)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-Hydroxy-N-((S)-1-(4-(4-Methylthiazol-5-Yl)Phenyl)Ethyl)Pyrrolidine-2-Carboxamide Hydrochloride

CAS: 1948273-03-7

(2S,4R)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-Hydroxy-N-((S)-1-(4-(4-Methylthiazol-5-Yl)Phenyl)Ethyl)Pyrrolidine-2-Carboxamide Hydrochloride

Purezza: 98%

Peso molecolare: 481.05g/mol

Ref: 54-OR1029403

(S,R,S)-AHPC-Me hydrochloride

CAS: 1948273-03-7

Purezza: 96%

Peso molecolare: 480.2

Ref: 10-F554450

E3 ligase Ligand 1

CAS: 1948273-03-7

E3 ligase Ligand 1 is a ligand that is used to monitor e3 ligases in the laboratory. It is a protein with a molecular weight of approximately 40 kDa and contains a cysteine residue at its N-terminus. The fluorescein moiety is covalently attached to the lysine side chain of the cysteine residue. This fluorescent molecule can be photoactivated by irradiation with light in order to induce proteolysis and release the fluorescent product, which can then be monitored by fluorescence microscopy. E3 ligase Ligand 1 has been shown to degrader proteins in vitro, as well as being able to trigger photocaging reactions and cause photoactivation of fluorophores.

Formula: C₂₃H₃₃ClN₄O₃S

Purezza: Min. 95%

Peso molecolare: 481.1 g/mol

Ref: 3D-FE178607