CAS 194979-70-9

(S)-Cpp sodium

CAS: 194979-70-9

Cpp is a peptide with a molecular weight of 8.7 kDa and a length of 6 amino acids. It was originally isolated from the venom of the Brazilian spider Phoneutria nigriventer, but has also been found in other organisms such as scorpions, bees, and sea anemones. Cpp is an activator of voltage-gated sodium ion channels. It binds to the extracellular domain of the sodium channel and opens it by changing its conformation. This binding prevents fast inactivation of sodium channels that are activated by depolarization. This inhibition leads to an increase in action potential duration and amplitude, which may be one mechanism underlying Cpp's neurotoxic effects.

Formula: C₉H₈ClNaO₂

Purezza: Min. 95%

Peso molecolare: 206.6 g/mol

Ref: 3D-UHA97970

(S)-CPP sodium

CAS: 194979-70-9

(S)-CPP sodium serves as an inhibitor of the branched-chain α-keto acid dehydrogenase complex (BCKDC) kinase, commonly referred to as BDK or keto acid dehydrogenase kinase. As a negative regulator of BCKDC activity, (S)-CPP (IC50 of 6.3 μM) inhibits BDK, which activates the complex, leading to a significant reduction in the levels of leucine/isoleucine and valine in the plasma of wild-type mice.

Formula: C₉H₈ClNaO₂

Colore e forma: Solid

Peso molecolare: 206.60

Ref: TM-T201099