CAS 19804-27-4

4-Metildifenidramina

Descrizione:

4-Metildifenidramina è un antistaminico appartenente alla classe della difenidramina, utilizzato principalmente per le sue proprietà sedative e antiallergiche. È caratterizzato dalla sua struttura chimica, che include due anelli fenilici e un gruppo metile attaccato all'atomo di azoto della struttura di base della difenidramina. Questa modifica migliora i suoi effetti farmacologici e altera la sua potenza e il profilo degli effetti collaterali rispetto al suo composto originale. La sostanza è tipicamente una polvere cristallina bianca o bianco sporco, che presenta bassa solubilità in acqua ma maggiore solubilità nei solventi organici. Il suo meccanismo d'azione coinvolge l'antagonismo del recettore H1 dell'istamina, che aiuta ad alleviare i sintomi delle reazioni allergiche, come prurito e naso che cola. Inoltre, a causa dei suoi effetti sedativi, a volte viene utilizzato in aiuti per il sonno da banco. I profili di sicurezza ed efficacia sono considerazioni importanti, come per qualsiasi farmaco, e gli effetti collaterali potenziali possono includere sonnolenza, secchezza delle fauci e vertigini. Come per tutti i farmaci, il dosaggio corretto e la guida medica sono essenziali per un uso sicuro.

Formula: C₁₈H₂₃NO

InChI: InChI=1S/C18H23NO/c1-15-9-11-17(12-10-15)18(20-14-13-19(2)3)16-7-5-4-6-8-16/h4-12,18H,13-14H2,1-3H3

InChI key: InChIKey=PJUYQWIDNIAHIZ-UHFFFAOYSA-N

SMILES: C(OCCN(C)C)(C1=CC=C(C)C=C1)C2=CC=CC=C2

Sinonimi:

• 2-((p-Methyl-alpha-phenylbenzyl)oxy)ethyl(dimethyl)amine
• 4-Methyldiphenhydramine
• Ethanamine, N,N-dimethyl-2-[(4-methylphenyl)phenylmethoxy]-
• Ethylamine, N,N-dimethyl-2-[(p-methyl-α-phenylbenzyl)oxy]-
• N,N-Dimethyl-2-[(4-methylphenyl)phenylmethoxy]ethanamine
• N,N-Dimethyl-N-[2-(p-methyl-α-phenylbenzyloxy)ethyl]amine
• N,N-dimethyl-2-[(4-methylphenyl)(phenyl)methoxy]ethanamine
• Toladryl
• p-Methylbenzhydryl 2-dimethylaminoethyl ether
• p-Methyldiphenhydramine

Orphenadrine Related Compound F (N,N-Dimethyl-2-[phenyl(p-tolyl)methoxy]ethanamine citrate)

CAS: 19804-27-4

Amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters, salts thereof, nesoi

Formula: C₁₈H₂₃NO·C₆H₈O₇

Colore e forma: White Powder

Peso molecolare: 461.20497

Ref: 45-1479064

Ethanamine, N,N-dimethyl-2-[(4-methylphenyl)phenylmethoxy]-

CAS: 19804-27-4

Formula: C₁₈H₂₃NO

Purezza: 98%

Colore e forma: Liquid

Peso molecolare: 269.3813

Ref: IN-DA002B92

N,N-Dimethyl-2-(phenyl(p-tolyl)methoxy)ethanamine

CAS: 19804-27-4

N,N-Dimethyl-2-(phenyl(p-tolyl)methoxy)ethanamine

Purezza: 98%

Peso molecolare: 269.39g/mol

Ref: 54-OR1067626

Toladryl (Diphenhydramine EP Impurity B, Dimenhydrinate EP Impurity G, Orphenadrine EP Impurity F, Orphenadrine USP Related Compound F (Free Form))

CAS: 19804-27-4

Formula: C₁₈H₂₃NO

Peso molecolare: 269.39

Ref: 4Z-T-442001

Toladryl

Prodotto controllato

CAS: 19804-27-4

Applications A diphenhydramine (D486900) analog classified as an antihistaminic.
References Bakker, R.A. et al.: Mol. Pharm., 60, 1133 (2001); Rekker, R.F. et al.: Arzneim.-Forsch., 21, 688 (1971);

Formula: C₁₈H₂₃NO

Colore e forma: Neat

Peso molecolare: 269.38

Ref: TR-T530800

Diphenhydramine EP Impurity B

CAS: 19804-27-4

Formula: C₁₈H₂₃NO

Peso molecolare: 269.38

Ref: ST-EA-CP-D23002

Toladryl

Prodotto controllato

CAS: 19804-27-4

Toladryl is a histamine receptor antagonist used to treat allergies and hay fever. It blocks the H1 histamine receptors in the body, preventing them from binding with histamine and causing allergic reactions. Toladryl also has a role in lowering blood pressure by blocking the alpha-1 adrenergic receptors, which are responsible for vasoconstriction. This drug is an aziridine derivative that has been synthesized using an asymmetric synthesis process. It has been shown to be effective in spastic conditions, such as multiple sclerosis, because it inhibits the transfer of potassium ions across nerve cells.

Formula: C₁₈H₂₃NO

Purezza: Min. 95%

Peso molecolare: 269.38 g/mol

Ref: 3D-FT28302

Toladryl

CAS: 19804-27-4

Toladryl is a derivative of Diphenhydramine that can cross the blood-brain barrier and exhibits oral activity, with antihistamine and anticholinergic properties. Its anticholinergic effects are approximately a tenth of those seen with Diphenhydramine, yet it offers 2-4 times the protection against lethal doses of histamine in guinea pigs. The side effects of Toladryl are fewer and milder compared to Diphenhydramine; however, at higher doses, it may cause symptoms such as insomnia, agitation, and disorientation related to the central nervous system. Toladryl is utilized in the research of allergic diseases.

Formula: C₁₈H₂₃NO

Colore e forma: Solid

Peso molecolare: 269.38

Ref: TM-T200797