CAS 2013-58-3

meclociclina

Descrizione:

meclociclina è un antibiotico semisintetico appartenente alla classe delle tetracicline, utilizzato principalmente per le sue proprietà antibatteriche ad ampio spettro. È efficace contro una varietà di batteri gram-positivi e gram-negativi, così come alcuni protozoi. La struttura chimica di meclociclina presenta un nucleo di naftacene, caratteristico delle tetracicline, e contiene gruppi funzionali specifici che migliorano la sua attività antimicrobica. meclociclina agisce inibendo la sintesi proteica batterica legandosi alla subunità ribosomiale 30S, impedendo così la traduzione dell'mRNA. Questo antibiotico viene tipicamente somministrato per via orale ed è utilizzato per trattare varie infezioni, comprese le infezioni delle vie respiratorie, le infezioni cutanee e alcune malattie sessualmente trasmissibili. Tuttavia, come altre tetracicline, meclociclina può causare effetti collaterali come disturbi gastrointestinali, fotosensibilità e potenziali effetti sullo sviluppo delle ossa e dei denti nei bambini. È importante utilizzare questo antibiotico in modo giudizioso per ridurre al minimo il rischio di resistenza agli antibiotici.

Formula: C₂₂H₂₁ClN₂O₈

InChI: InChI=1S/C22H21ClN2O8/c1-6-9-7(23)4-5-8(26)11(9)16(27)12-10(6)17(28)14-15(25(2)3)18(29)13(21(24)32)20(31)22(14,33)19(12)30/h4-5,10,14-15,17,26,28-30,33H,1H2,2-3H3,(H2,24,32)/t10-,14-,15+,17+,22+/m1/s1

InChI key: InChIKey=GGQJXCQBBONZFX-IWVLMIASSA-N

SMILES: O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)([C@@H](O)[C@]3(C(=C2O)C(=O)C=4C(C3=C)=C(Cl)C=CC4O)[H])[H]

Sinonimi:

• (2E,4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylidene-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione
• (2E,4aR,5S,5aS,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylidene-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione
• (2Z)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylidene-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione
• (2Z,4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylidene-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione
• (4S,4aR,5S,5aR,12aS)-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, (4S,4aR,5S,5aR,12aS)-
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,12aalpha))-
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, [4S-(4α,4aα,5α,5aα,12aα)]-
• 2-hydroxy-5-sulfobenzoic acid - (4S,4aR,5S,5aR,12aS)-7-chloro-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methylidene-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide (1:1)
• 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide
• 7-Chloro-6-methylene-5-oxytetracycline
• 7-Cloro-6-metilene-5-ossitetraciclina
• 7-Cloro-6-metilene-5-ossitetraciclina [Italian]
• Gs 2989
• Meclociclina
• Meclociclina [INN-Spanish]
• Meclociclina [Italian]
• Meclocycline [USAN:INN:BAN]
• Meclocyclinum
• Meclocyclinum [INN-Latin]
• Nsc 78502
• Unii-23Q8M2He6S
• Meclocycline
• 7-Chloro-6-Methylene-oxytetracycline, GS 2989, NCS 78502
• GGQJXCQBBONZFX-IWVLMIASSA-N
• MECLOCYLINE
• meclocycline USP/EP/BP
• Meclocycline(usan)
• Meclocycline base
• Chlormethylenecycline
• (4S)-4β-(Dimethylamino)-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,5β,10,12,12aβ-pentahydroxy-6-methylene-7-chloro-1,11-dioxo-2-naphthacenecarboxamide
• Aids-043973
• Meclocycline (1.0mg/ml in DMSO)
• Aids043973

Meclocycline

Prodotto controllato

CAS: 2013-58-3

Stability Light Sensitive
Applications Meclocycline is a close structural analogue of methacycline which shows antibacterial and antiprotozoan activity.

Formula: C₂₂H₂₁ClN₂O₈

Colore e forma: Neat

Peso molecolare: 476.86

Ref: TR-M202723

Meclocycline

CAS: 2013-58-3

Meclocycline: a tetracycline antibiotic, inhibits LDH, reduces cell toxicity from mutant huntingtin, doesn't change protein levels in PC12 cells.

Formula: C₂₂H₂₁ClN₂O₈

Colore e forma: Solid

Peso molecolare: 476.86

Ref: TM-T71903