CAS 2018-66-8

Benzyloxi-carbonil-L-leucina

Descrizione:

Benzyloxi-carbonil-L-leucina, comunemente noto come Z-Leu, è un derivato dell'aminoacido leucina, caratterizzato dalla presenza di un gruppo protettivo benzyloxycarbonile (Z). Questo composto è tipicamente utilizzato nella sintesi di peptidi come gruppo protettivo per il gruppo amminico della leucina, facilitando la formazione di legami peptidici senza interferenze dal gruppo amminico. Z-Leu è un solido cristallino bianco a bianco sporco, ed è solubile in solventi organici come metanolo e dimetilsolfossido, ma ha una solubilità limitata in acqua. La presenza del gruppo benzyloxycarbonile migliora la stabilità dell'aminoacido durante le reazioni chimiche, rendendolo un intermedio prezioso nella sintesi di peptidi e proteine più complesse. Inoltre, Z-Leu può essere deprotetto in condizioni specifiche, consentendo la rigenerazione del gruppo amminico libero per ulteriori reazioni. Il suo numero CAS, 2018-66-8, è utilizzato per l'identificazione in banche dati chimiche e contesti normativi. In generale, Benzyloxi-carbonil-L-leucina gioca un ruolo significativo nella chimica organica e nella biochimica, in particolare nel campo della sintesi di peptidi.

Formula: C₁₄H₁₉NO₄

InChI: InChI=1S/C14H19NO4/c1-10(2)8-12(13(16)17)15-14(18)19-9-11-6-4-3-5-7-11/h3-7,10,12H,8-9H2,1-2H3,(H,15,18)(H,16,17)/t12-/m0/s1

InChI key: InChIKey=USPFMEKVPDBMCG-LBPRGKRZSA-N

SMILES: C(OC(N[C@@H](CC(C)C)C(O)=O)=O)C1=CC=CC=C1

Sinonimi:

• (2S)-2-[[(Benzyloxy)carbonyl]amino]-4-methylpentanoic acid
• (2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoate
• (2S)-4-Methyl-2-(phenylmethoxycarbonylamino)pentanoic acid
• (Benzyloxycarbonyl)leucine
• (Carbobenzoxy)leucine
• (Carbobenzyloxy)-<span class="text-smallcaps">L</span>-leucine
• <span class="text-smallcaps">L</span>-(Carbobenzyloxy)leucine
• <span class="text-smallcaps">L</span>-Leucine, N-[(phenylmethoxy)carbonyl]-
• <span class="text-smallcaps">L</span>-N-(Benzyloxycarbonyl)leucine
• Benzyloxycarbonyl-<span class="text-smallcaps">L</span>-leucine
• CBZ-<span class="text-smallcaps">L</span>-leucine
• Carbobenzoxy-<span class="text-smallcaps">L</span>-leucine
• Cbz-L-leucine
• Leucine, N-carboxy-, N-benzyl ester
• Leucine, N-carboxy-, N-benzyl ester, <span class="text-smallcaps">L</span>-
• N-(Benzyloxycarbonyl)-<span class="text-smallcaps">L</span>-leucine
• N-(Benzyloxycarbonyl)leucine
• N-(Carbobenzoxy)leucine
• N-Carbobenzoxy-<span class="text-smallcaps">L</span>-leucine
• N-Carbobenzyloxy-<span class="text-smallcaps">L</span>-leucine
• N-Carboxy-<span class="text-smallcaps">L</span>-leucine N-benzyl ester
• N-[(Phenylmethoxy)carbonyl]-<span class="text-smallcaps">L</span>-leucine
• N-[(benzyloxy)carbonyl]-D-leucine
• N-[(benzyloxy)carbonyl]-L-leucine
• N-[(benzyloxy)carbonyl]leucine
• N-cbz-l-leucine
• NSC 60039
• Nα-Benzyloxycarbonyl-L-leucine
• Z-Leu-OH
• z-Leu
• L-Leucine, N-[(phenylmethoxy)carbonyl]-
• Leucine, N-carboxy-, N-benzyl ester, L-
• N-[(Phenylmethoxy)carbonyl]-L-leucine

N-Benzyloxycarbonyl-L-leucine

CAS: 2018-66-8

Formula: C₁₄H₁₉NO₄

Purezza: >96.0%(T)

Colore e forma: Colorless to Light yellow clear liquid

Peso molecolare: 265.31

Ref: 3B-C0739

Z-Leu-OH (oil)

CAS: 2018-66-8

Bachem ID: 4000522.

Formula: C₁₄H₁₉NO₄

Purezza: > 98%

Colore e forma: White Oily

Peso molecolare: 265.31

Ref: 01-4000522

N-Carbobenzyloxy-L-leucine

CAS: 2018-66-8

Formula: C₁₄H₁₉NO₄

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 265.3050

Ref: IN-DA0035DD

N-Cbz-L-Leucine

CAS: 2018-66-8

N-Cbz-L-Leucine

Purezza: ≥98%

Peso molecolare: 265.3g/mol

Ref: 54-BUP19528

N-Cbz-L-Leucine

CAS: 2018-66-8

N-Cbz-L-Leucine

Purezza: 98%

Peso molecolare: 265.3g/mol

Ref: 54-OR1029931

Z-Leu-OH

CAS: 2018-66-8

Formula: C₁₄H₁₉NO₄

Purezza: ≥ 96.0%

Colore e forma: Light yellow liquid

Peso molecolare: 265.30

Ref: 7W-GM9292

N-Cbz-L-Leucine

CAS: 2018-66-8

N-Cbz-L-Leucine (N-[(Phenylmethoxy)carbonyl]-L-leucine) is a leucine derivative, a commonly used amino acid protecting group.

Formula: C₁₄H₁₉NO₄

Purezza: 99.59%

Colore e forma: Solid

Peso molecolare: 265.3

Ref: TM-T64400

N-Benzyloxycarbonyl-L-leucine

CAS: 2018-66-8

N-Benzyloxycarbonyl-L-leucine is a peptidomimetic that has been shown to be effective against P. aeruginosa. The peptidyl amino group has a nucleophilic character, which allows it to react with the carboxyl group of L-lysine and form an amide bond. N-Benzyloxycarbonyl-L-leucine was found to be effective at low doses in inhibiting the growth of P. aeruginosa, and may also have therapeutic potential for treating lymphocytic leukemia. This compound is racemized into its two stereoisomers, D-N-benzyloxycarbonyl-L-leucine and L-N-benzyloxycarbonyl-L-leucine, which have different effects on cell membranes.

Formula: C₁₄H₁₉NO₄

Purezza: Min. 98 Area-%

Colore e forma: Clear Liquid

Peso molecolare: 265.31 g/mol

Ref: 3D-FB36690

Z-L-Leucine extrapure, 98%

CAS: 2018-66-8

Formula: C₁₄H₁₉NO₄

Purezza: min. 98%

Colore e forma: Clear, Colourless to pale yellow, Viscous liquid

Peso molecolare: 265.30

Ref: SR-85612

Cbz-Leucine

CAS: 2018-66-8

Formula: C₁₄H₁₉NO₄

Purezza: 95%

Colore e forma: Liquid

Peso molecolare: 265.309

Ref: 10-F032700

N-Cbz-L-leucine

Prodotto controllato

CAS: 2018-66-8

Applications N-Cbz-L-Leucine is an N-Cbz-protected form of L-Leucine (L330110). L-Leucine is an essential amino acid that induces a sharp decrease in blood glucose levels in individuals with idiopathic familial hypoglycemia, but has no known effects on normal, healthy individuals. L-Leucine also acts as an Isoleucine (I820210) antagonist in the rat, causing delays in growth, and is a potential tumour promoter of bladder cancer.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Fajans, S., et al.: J. Clin. Inv., 42, 216 (1963); Harper, A., et al.: Arch. Biochem. Biophys., 57, 1 (1955); Nishio, Y., et al.: Science, 231, 843 (1986)

Formula: C₁₄H₁₉NO₄

Colore e forma: Neat

Peso molecolare: 265.30

Ref: TR-C227760