CAS 20623-13-6

nitritocobalamina

Descrizione:

nitritocobalamina, con il numero CAS 20623-13-6, è un derivato della cobalamina, comunemente nota come vitamina B12. Questo composto presenta un gruppo nitrito (-ONO) attaccato al centro di cobalto della struttura della cobalamina, che è essenziale per varie funzioni biologiche. nitritocobalamina è caratterizzato dalla sua complessa chimica di coordinazione, dove il cobalto può esistere in diversi stati di ossidazione, influenzando la sua reattività e attività biologica. È tipicamente un solido cristallino di colore rosso-viola, solubile in acqua, e mostra stabilità in determinate condizioni. La presenza del gruppo nitrito può influenzare la sua interazione con le molecole biologiche e la sua biodisponibilità complessiva. Mentre la cobalamina è cruciale per la sintesi del DNA e la formazione dei globuli rossi, i ruoli biologici specifici di nitritocobalamina e le sue potenziali applicazioni in medicina o biochimica sono meno studiati. Come molti derivati della cobalamina, potrebbe avere implicazioni nella ricerca relativa alla catalisi enzimatica e ai percorsi metabolici. In generale, nitritocobalamina rappresenta un'area di studio interessante nel contesto più ampio della chimica della vitamina B12.

Formula: C₆₂H₈₈CoN₁₃O₁₄P·NO₂

InChI: InChI=1/C62H90N13O14P.Co.HNO2/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;2-1-3/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;(H,2,3)/q;+3;/p-3

InChI key: InChIKey=UUWYBLVKLIHDAU-UHFFFAOYSA-K

SMILES: [O-](N=O)[Co+3]1234[N]=5C6(C)C7[N-]1C(C(C)(C7CC(N)=O)CCC(=O)NCC(C)OP(=O)([O-])OC8C(O)C(N9C=[N]2C=%10C9=CC(C)=C(C)C%10)OC8CO)=C(C)C%11=[N]3C(=CC%12=[N]4C(=C(C)C5C(CCC(N)=O)C6(CC(N)=O)C)C(CC(N)=O)(C)C%12CCC(N)=O)C(C)(C)C%11CCC(N)=O

Sinonimi:

• Cobalamin, nitro-
• Cobinamide, Co-(nitrito-κO)-, dihydrogen phosphate (ester), inner salt, 3′-ester with (5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole-κN³)
• Cobinamide, hydroxide nitrite (salt), dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosylbenzimidazole
• Cobinamide, nitrite (salt), dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole
• Cobinamide, nitrite phosphate, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosylbenzimidazole, inner salt
• Nitrocobalamin
• Vitamin B12c
• Vitamin B_12c
• Cobinamide, Co-(nitrito-κO)-, dihydrogen phosphate (ester), inner salt, 3′-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3)
• Cobinamide, nitrite phosphate, 3′-ester with 5,6-dimethyl-1-α-D-ribofuranosylbenzimidazole, inner salt
• Cobinamide, nitrite (salt), dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole
• Cobinamide, hydroxide nitrite (salt), dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-D-ribofuranosylbenzimidazole
• Nitritocobalamin

Nitritocobalamin

CAS: 20623-13-6

Formula: C₆₂H₈₈CoN₁₃O₁₄P·NO₂

Peso molecolare: 1329.38 46.01

Ref: 4Z-V-035004

Nitritocobalamin (>85% by HPLC)

Prodotto controllato

CAS: 20623-13-6

Applications Nitritocobalamin is a useful synthetic intermediate in the synthesis of Hydroxocobalamin Acetate (H826800); a physiological analog of vitamin B12 where the CN group is replaced with OH. Exists in aqueous solution as an equilibrium mixture of the hydroxy isomer and the ionic aqua isomer (aquacobalamin). Precursor of the coenzymes methylcobalamin and cobamamide. Coordination Compound. Vitamin (hematopoietic).
References Kaczka, E.A., et al.: Science, 112, 354 (1950); Friedrich, W., et al.: Vitamins, 837 (1988); Forsyth, J.C., et al.: Clin. Toxicol., 31, 277 (1993)

Formula: C₆₂H₈₈CoN₁₄O₁₆P

Purezza: >85% by HPLC

Colore e forma: Neat

Peso molecolare: 1375.35

Ref: TR-N490240

Nitritocobalamin

CAS: 20623-13-6

Nitritocobalamin is a crystalline cellulose that is used as a chinese herb. It has been shown to have beneficial effects on pancreatic function and fatty acid metabolism in humans. Nitritocobalamin also has the ability to reduce nitrite ions to nitric oxide, which is important for human liver health. Nitritocobalamin is also known for its ability to inhibit the production of low-density lipoprotein-cholesterol (LDL-C) and cell proliferation in cultured cells. The target enzyme nitrite reductase was found to be inhibited by nitritocobalamin in both rat liver and human liver cell lines. In addition, melaleuca alternifolia showed low expression of nitrite reductase, which may be due to inhibition by nitritocobalamin.

Formula: C₆₂H₈₈CoN₁₄O₁₆P

Purezza: 85%Min

Peso molecolare: 1,375.35 g/mol

Ref: 3D-FN173311

Nitritocobalamin

CAS: 20623-13-6

Formula: C₆₂H₈₈CoN₁₃O₁₄PNO₂

Peso molecolare: 1329.38 : 46.01

Ref: ST-EA-CP-H13002