CAS 207399-07-3

IR 780

Descrizione:

IR 780, con il numero CAS 207399-07-3, è un colorante fluorescente nell'infrarosso vicino (NIR) che viene utilizzato principalmente in applicazioni di imaging biologico e terapia fototermica. Questo composto mostra una forte assorbimento nella regione dell'infrarosso vicino, il che consente una penetrazione più profonda nei tessuti e riduce la fluorescenza di fondo, rendendolo particolarmente utile nella diagnostica medica e nella ricerca. IR 780 è caratterizzato dalla sua alta fotostabilità e bassa tossicità, che sono essenziali per l'imaging in vivo. Inoltre, è stato studiato per il suo potenziale nei sistemi di somministrazione mirata di farmaci grazie alla sua capacità di accumularsi selettivamente in alcuni tipi di cellule tumorali. Le proprietà uniche del colorante gli consentono di fungere da strumento prezioso sia nella ricerca fondamentale che nelle applicazioni cliniche, in particolare nei campi dell'oncologia e dell'imaging molecolare. In generale, IR 780 rappresenta un significativo progresso nello sviluppo di agenti di imaging che possono migliorare la visualizzazione dei processi biologici in tempo reale.

Formula: C₃₆H₄₄ClN₂·I

InChI: InChI=1S/C36H44ClN2.HI/c1-7-24-38-30-18-11-9-16-28(30)35(3,4)32(38)22-20-26-14-13-15-27(34(26)37)21-23-33-36(5,6)29-17-10-12-19-31(29)39(33)25-8-2;/h9-12,16-23H,7-8,13-15,24-25H2,1-6H3;1H/q+1;/p-1

InChI key: InChIKey=IRPKBYJYVJOQHQ-UHFFFAOYSA-M

SMILES: C(CC)N1C=2C(C(C)(C)C1=CC=C3C(Cl)=C(C=CC4=[N+](CCC)C=5C(C4(C)C)=CC=CC5)CCC3)=CC=CC2.[I-]

Sinonimi:

• 2-[(Z)-2-{(3E)-2-chloro-3-[(2E)-2-(3,3-dimethyl-1-propyl-1,3-dihydro-2H-indol-2-ylidene)ethylidene]cyclohex-1-en-1-yl}ethenyl]-3,3-dimethyl-1-propyl-3H-indolium iodide
• 3H-Indolium, 2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propyl-, iodide
• 3H-Indolium, 2-(2-(2-chloro-3-(2-(1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propyl-, iodide (1:1)
• Ads 775Pi
• Ir 780
• IR 780 iodide

11-Chloro-1,1'-di-n-propyl-3,3,3',3'-tetramethyl-10,12-trimethyleneindatricarbocyanine iodide, 95%

CAS: 207399-07-3

11-Chloro-1,1'-di-n-propyl-3,3,3',3'-tetramethyl-10,12-trimethyleneindatricarbocyanine iodide is used as a laser and IR dye. It is also used as lithographic computer to plate laser applications. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. S

Formula: C₃₆H₄₄ClIN₂

Purezza: 95%

Colore e forma: Green/gold to dark green, Crystals or crystalline powder

Peso molecolare: 667.12

Ref: 02-H32150

3H-Indolium,2-[2-[2-chloro-3-[(1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene]-1-cyclohexen-1-yl]ethenyl]-3,3-dimethyl-1-propyl-, iodide

CAS: 207399-07-3

Formula: C₃₆H₄₄ClIN₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 667.1054

Ref: IN-DA01FL1R

IR-780 Iodide

CAS: 207399-07-3

IR-780 Iodide

Purezza: ≥98%

Peso molecolare: 667.12g/mol

Ref: 54-BUP11850

11-Chloro-1,1’-Di-N-Propyl-3,3,3’,3’-Tetramethyl-10,12-Trimethyleneindatricarbocyanine Iodide

CAS: 207399-07-3

11-Chloro-1,1’-Di-N-Propyl-3,3,3’,3’-Tetramethyl-10,12-Trimethyleneindatricarbocyanine Iodide

Purezza: 98%

Peso molecolare: 667.11g/mol

Ref: 54-OR1009322

IR 780

CAS: 207399-07-3

Formula: C₃₆H₄₄ClIN₂

Purezza: >95.0%(HPLC)(qNMR)

Colore e forma: Yellow to Brown to Dark green powder to crystal

Peso molecolare: 667.12

Ref: 3B-I1281

IR-780 Iodide

CAS: 207399-07-3

IR-780 Iodide: a near-infrared dye for HIF-1α/glycolysis ABCB10-dependent human CSC characterization.

Formula: C₃₆H₄₄ClIN₂

Purezza: 99.98%

Colore e forma: Solid

Peso molecolare: 667.12

Ref: TM-T20974

IR-780 iodide

CAS: 207399-07-3

IR-780 iodide is a water-soluble drug that has been shown to have significant cytotoxicity against prostate cancer cells. It binds to the mitochondrial membrane potential, which is involved in energy production and the regulation of the cell cycle. IR-780 iodide is taken up by tumor cells, where it inhibits adriamycin uptake and induces apoptosis. In vitro assays have shown that IR-780 iodide can be used as a diagnostic tool for detecting bladder cancer by binding to the mitochondria of cells from patients with bladder cancer. In vivo studies have been done in mice to determine the effectiveness of IR-780 iodide in treating cervical cancer. These studies showed that IR-780 iodide was not significantly effective in vivo, due to its low bioavailability and lack of specificity for cervical cancer cells. Histological analysis showed that IR-780 iodide did not inhibit tumor growth or induce apoptosis in vivo.

Formula: C₃₆H₄₄ClIN₂

Purezza: Min. 95%

Peso molecolare: 667.11 g/mol

Ref: 3D-HIA39907