CAS 208255-80-5

Inibitore della γ-secretasi IX

Descrizione:

Inibitore della γ-secretasi IX è un composto a piccole molecole noto per il suo ruolo nell'inibizione del complesso γ-secretasi, che è cruciale nel processamento della proteina precursore dell'amiloide (APP) e nella produzione di peptidi di amiloide-beta. Questa inibizione è di particolare interesse nella ricerca sulla malattia di Alzheimer, poiché l'accumulo di amiloide-beta è associato alla neurodegenerazione. Il composto è caratterizzato dalla sua capacità di interferire selettivamente con l'attività enzimatica della γ-secretasi, modulando così le vie di segnalazione coinvolte nella proliferazione e differenziazione cellulare. La sua struttura chimica include tipicamente gruppi funzionali specifici che migliorano la sua affinità di legame al sito attivo del complesso γ-secretasi. In ambienti di laboratorio, Inibitore della γ-secretasi IX è utilizzato in vari saggi per studiare gli effetti dell'inibizione della γ-secretasi sui processi cellulari ed esplorare potenziali strategie terapeutiche per le malattie neurodegenerative. Come per molti agenti farmacologici, l'efficacia e il profilo di sicurezza del composto sono critici per la sua potenziale applicazione in contesti clinici.

Formula: C₂₃H₂₆F₂N₂O₄

InChI: InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1

InChI key: InChIKey=DWJXYEABWRJFSP-XOBRGWDASA-N

SMILES: [C@@H](NC([C@@H](NC(CC1=CC(F)=CC(F)=C1)=O)C)=O)(C(OC(C)(C)C)=O)C2=CC=CC=C2

Sinonimi:

• An-37124
• DAPT (enzyme inhibitor)
• Dapt
• Glycine, N-[(3,5-difluorophenyl)acetyl]-<span class="text-smallcaps">L</span>-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
• Glycine, N-[2-(3,5-difluorophenyl)acetyl]-<span class="text-smallcaps">L</span>-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
• Gsi-Ix
• Ly-374973
• N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester
• N-[N-(3,5-Difluorophenacetyl)-<span class="text-smallcaps">L</span>-alanyl]-S-phenylglycine tert-butyl ester
• N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester
• tert-butyl (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)ethanoate
• γ-Secretase inhibitor IX
• Glycine, N-[(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-

DAPT

CAS: 208255-80-5

Formula: C₂₃H₂₆F₂N₂O₄

Purezza: >97.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 432.47

Ref: 3B-D4257

DAPT

CAS: 208255-80-5

A cell-permeable dipeptide that suppresses A production by blocking -secretase

Formula: C₂₃H₂₆F₂N₂O₄

Colore e forma: Solid, White

Peso molecolare: 432.47

Ref: 02-J65864

Glycine, N-[2-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-

CAS: 208255-80-5

Formula: C₂₃H₂₆F₂N₂O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 432.4603

Ref: IN-DA002JLH

DAPT

CAS: 208255-80-5

DAPT

Purezza: ≥98%

Peso molecolare: 432.46g/mol

Ref: 54-BUP15441

DAPT

CAS: 208255-80-5

DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active.

Formula: C₂₃H₂₆F₂N₂O₄

Purezza: 98.06% - 99.81%

Colore e forma: White Solid

Peso molecolare: 432.46

Ref: TM-T6202

DAPT

CAS: 208255-80-5

DAPT

Purezza: 98%

Peso molecolare: 432.46g/mol

Ref: 54-BISN0140

DAPT

CAS: 208255-80-5

Formula: C₂₃H₂₆F₂N₂O₄

Purezza: (NMR) ≥ 98.0%

Colore e forma: White to off-white solid

Peso molecolare: 432.50

Ref: 7W-GK0567

DAPT

CAS: 208255-80-5

Applications DAPT is a γ-secretase inhibitor which inhibits thegrowth of cancer cells and epethelial and mesenchymal transition (1,2).
References (1) Li, L. et al.: Oncol Lett. 7, 2160 (2014) (2) Wang, M. et al.: Int. J. Onc., 44, 1401 (2014)

Formula: C₂₃H₂₆F₂N₂O₄

Colore e forma: Off White Solid

Peso molecolare: 432.46

Ref: TR-D193290

(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu

CAS: 208255-80-5

(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu is a secretase inhibitor that inhibits the enzyme that cleaves amyloid precursor protein (APP) to release beta-amyloid. It has been shown to prevent the formation of plaques in the brain and may be used to treat Alzheimer's disease. (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu has also been shown to inhibit the production of tumor necrosis factor alpha (TNFα), which is involved in inflammation and carcinogenesis. The drug has been shown to reduce myocardial infarct size by preventing cardiac cell death and reducing inflammation following a heart attack. It is also active against multiple types of cancer cells, including carcinoma cell lines and multidrug resistant cells.

Formula: C₂₃H₂₆N₂O₄F₂

Purezza: Min. 95%

Peso molecolare: 432.47 g/mol

Ref: 3D-IGS-3641-PI

DAPT

CAS: 208255-80-5

Inhibitor of proteaseγ‐secretase, which allows to modulate of the activity of γ‐secretase substrates Notch, E-cadherin, ErbB4, and amyloid precursor protein (APP). The compound can inhibit the growth of tongue carcinoma cells by arresting cell cycle in G0–G1 phase, modulate the activity of Notch1 receptor and Caspase-3 protease and induce apoptosis. It was also demonstrated that this inhibitor reduces the levels of β-amyloid peptide in the brain of mice model for Alzheimer’s disease. This compound also enhances the neuronal differentiation embryonic cells.

Formula: C₂₃H₂₆O₄N₂F₂

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 432.46 g/mol

Ref: 3D-FT34136

(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu

CAS: 208255-80-5

(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu is a peptide that is an inhibitor of Protein interactions. It blocks the binding of the enzyme to its substrate and prevents the conversion of substrate to product. This peptide was used as a research tool for studying protein interactions in cell biology and as an activator for Ligands. This peptide can be used as a reagent for antibody production. The purity of this peptide is high and it has been shown to have no adverse effects in animal research studies.

Formula: C₂₃H₂₆N₂O₄F₂

Purezza: Min. 95%

Peso molecolare: 432.46 g/mol

Ref: 3D-IGS-3219-V