CAS 20830-75-5

Digossina

Descrizione:

Digossina è un glicoside cardiaco derivato dalle foglie della pianta di digitale (Digitalis purpurea) ed è utilizzato principalmente nel trattamento di varie condizioni cardiache, in particolare la fibrillazione atriale e l'insufficienza cardiaca. Funziona inibendo la pompa ATPasi sodio-potassio, portando a un aumento delle concentrazioni di calcio intracellulare, il che migliora la contrattilità cardiaca. Digossina è caratterizzato da una finestra terapeutica relativamente stretta, il che significa che la differenza tra una dose efficace e una dose tossica è piccola, richiedendo un attento monitoraggio dei livelli sierici nei pazienti. Viene tipicamente somministrato per via orale o endovenosa ed è noto per i suoi potenziali effetti collaterali, che possono includere disturbi gastrointestinali, cambiamenti visivi e aritmie. La sostanza ha una formula molecolare di C41H64O14 e un peso molecolare di circa 780,94 g/mol. La farmacocinetica di Digossina è influenzata da fattori come la funzione renale e le interazioni con altri farmaci, rendendo essenziale una dosaggio personalizzato per un uso sicuro ed efficace.

Formula: C₄₁H₆₄O₁₄

InChI: InChI=1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1

InChI key: InChIKey=LTMHDMANZUZIPE-PUGKRICDSA-N

SMILES: O[C@@]12[C@@](C)([C@H](CC1)C3=CC(=O)OC3)[C@H](O)C[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O[C@H]8C[C@H](O)[C@H](O)[C@@H](C)O8)[C@@H](C)O7)[C@@H](C)O6)C5)[H])[H])[H]

Sinonimi:

• (3beta,5beta,12beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• (3beta,5beta,8xi,9xi,12beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• (3β,5β,12β)-3-[(O-2,6-Dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
• 12β-Hydroxydigitoxin
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• Cardigox
• Cardiogoxin
• Cardioxin
• Cardixin
• Cardoxin
• Chloroformic digitalin
• Coragoxine
• Cordioxil
• Davoxin
• Digacin
• Digicor
• Digitek
• Digitoxin, 12β-hydroxy-
• Digomal
• Digon
• Digosin
• Digoxin (FDA)
• Digoxin Nativelle
• Digoxina
• Digoxine
• Dilanacin
• Dixina
• Dokim
• Dynamos
• Eudigox
• Fargoxin
• Grexin
• Homolle's digitalin
• Lanacordin
• Lanacrist
• Lanicor
• Lanikor
• Lanocardin
• Lanorale
• Lanoxicaps
• Lanoxin
• Lanoxin PG
• Lenoxicaps
• Lenoxin
• Longdigox
• Mapluxin
• Natigoxin
• NeoDioxanin
• Novodigal-Amp.
• Nsc 95100
• Purgoxin
• Rougoxin
• Stillacor
• Toloxin
• Vanoxin
• (3β,5β,12β)-3-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide

Digoxin, 96%

CAS: 20830-75-5

Digoxin, 96%, Thermo Scientific Chemicals

Formula: C₄₁H₆₄O₁₄

Purezza: 96%

Colore e forma: Powder, White

Peso molecolare: 780.95

Ref: 02-B21902

Digoxin

CAS: 20830-75-5

Digoxin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Formula: C₄₁H₆₄O₁₄

Purezza: (HPLC) ≥95%

Colore e forma: Powder

Peso molecolare: 780.95

Ref: 11-0830

Digoxin 1.0 mg/ml in Methanol

CAS: 20830-75-5

Colore e forma: Colourless

Ref: 61-AMP0212.00-01

Digoxin, 1mg/ml in Methanol

CAS: 20830-75-5

Colore e forma: Colourless

Ref: LP-DOX-1921-1LM

Digoxin

CAS: 20830-75-5

Colore e forma: Neat

Ref: 61-FOR0212.00

DIGOXIN FOR PEAK IDENTIFICATION CRS

CAS: 20830-75-5

DIGOXIN FOR PEAK IDENTIFICATION CRS

Formula: C₄₁H₆₄O₁₄

Peso molecolare: 780.9385

Ref: 41-Y0000554

DIGOXIN CRS

CAS: 20830-75-5

DIGOXIN CRS

Formula: C₄₁H₆₄O₁₄

Colore e forma: White. Whitish. Powder.

Peso molecolare: 780.9385

Ref: 41-D1900000

DIGOXIN RS

CAS: 20830-75-5

DIGOXIN RS

Formula: C₄₁H₆₄O₁₄

Peso molecolare: 780.9385

Ref: 41-ICRS0289

Digoxin

CAS: 20830-75-5

Other glycosides, natural or reproduced by synthesis, a

Formula: C₄₁H₆₄O₁₄

Colore e forma: White Translucent Crystalline Powder Crystals

Peso molecolare: 780.94

Ref: 45-1200000

Digoxin

CAS: 20830-75-5

Formula: C₄₁H₆₄O₁₄

Purezza: ≥ 94.5% (anhydrous basis)

Colore e forma: White to off-white powder

Peso molecolare: 780.95

Ref: 7W-GC1807

Digoxin

CAS: 20830-75-5

Formula: C₄₁H₆₄O₁₄

Colore e forma: White To Off-White Solid

Peso molecolare: 780.95

Ref: 4Z-D-751

Digoxin, USP grade

CAS: 20830-75-5

Formula: C₄₁H₆₄O₁₄

Peso molecolare: 780.95

Ref: 7W-GC1100

Digoxin

CAS: 20830-75-5

Digoxin

Purezza: 96%

Colore e forma: White Solid

Peso molecolare: 780.94g/mol

Ref: 54-BID2190

Digoxin-d3

CAS: 127299-95-0, 20830-75-5

Formula: C₄₁H₆₁D₃O₁₄

Colore e forma: Off-White Solid

Peso molecolare: 783.98

Ref: 4Z-D-752

Digoxin

Prodotto controllato

CAS: 20830-75-5

Formula: C₄₁H₆₄O₁₄

Colore e forma: Neat

Peso molecolare: 780.94

Ref: 04-C12633850

Digoxin

CAS: 20830-75-5

Colore e forma: Neat

Ref: LP-DOX-1921-10

Digoxin

CAS: 20830-75-5

Digoxin is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure. Digoxin and other cardiac glycosides can inhibit hypoxia-inducible factor 1 (HIF-1)α synthesis and block tumor growth.

Formula: C₄₁H₆₄O₁₄

Purezza: 95%~99%

Peso molecolare: 780.949

Ref: BP-BP0490

Digoxin

CAS: 20830-75-5

Formula: C₄₁H₆₄O₁₄

Purezza: >96.0%(HPLC)

Colore e forma: White to Almost white powder to crystaline

Peso molecolare: 780.95

Ref: 3B-D1828

Digoxin

Prodotto controllato

CAS: 20830-75-5

Formula: C₄₁H₆₄O₁₄

Colore e forma: White

Peso molecolare: 780.94

Ref: 86-MM0212.00

Digoxin RS

CAS: 20830-75-5

Colore e forma: Colorless To White

Ref: 2K-1065000021

Digoxin

Prodotto controllato

CAS: 20830-75-5

Applications Cardiotonic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Aronson, J.K., et al.: Clin. Pharmacokinet, 5,137 (1980), Foss, P.R.B., Anal. Profiles Drug Subs., 9, 207 (1980),

Formula: C₄₁H₆₄O₁₄

Colore e forma: White

Peso molecolare: 780.94

Ref: TR-D446575

12β-Hydroxydigitoxin

CAS: 20830-75-5

Please enquire for more information about 12beta-Hydroxydigitoxin including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₄₁H₆₄O₁₄

Peso molecolare: 780.95 g/mol

Ref: 3D-J-013666

Digoxin

CAS: 20830-75-5

Digoxin and its derivatives are the most widely used as cardiac glycosides. Digoxin is isolated from the foxglove plant, Digitalis lanata, and has pharmacokinetic properties that are intermediate between digitoxin and the short acting strophanthus glycosides. Digoxin is regarded as the drug of choice for the treatment of congestive heart failure as its main assets are the rapid onset of action, good absorption ratio and the medium half-life which makes toxic reactions easier to manage (Albrecht, 1999).

Formula: C₄₁H₆₄O₁₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 780.94 g/mol

Ref: 3D-OD01513

Digoxin extrapure, 95%

CAS: 20830-75-5

Formula: C₄₁H₆₄O₁₄

Purezza: min. 95%

Colore e forma: White to off white, Crystalline powder, Clear

Peso molecolare: 780.94

Ref: SR-48712