CAS 20830-81-3: Daunorubicina

Descrizione: Daunorubicina è un antibiotico antraciclino che viene utilizzato principalmente nella chemioterapia per il cancro, in particolare per trattare alcuni tipi di leucemia, come la leucemia mieloide acuta (LMA) e la leucemia linfoblastica acuta (LLA). È derivato dal batterio Streptomyces peucetius e funziona intercalandosi nel DNA, inibendo così la sintesi di DNA e RNA, il che porta infine alla morte cellulare. Daunorubicina è caratterizzato dal suo colore rosso, che è indicativo della sua struttura antraciclina. Il composto ha una struttura molecolare complessa che include un sistema ad anello tetraciclico, essenziale per la sua attività biologica. Viene generalmente somministrato per via endovenosa e può presentare effetti collaterali come cardiotossicità, mielosoppressione e nausea. A causa dei suoi potenti effetti, Daunorubicina è spesso utilizzato in combinazione con altri agenti chemioterapici per migliorare l'efficacia terapeutica mentre si gestisce la resistenza potenziale. Il suo utilizzo è attentamente monitorato e il dosaggio viene regolato in base alla risposta e alla tolleranza del paziente.

Formula: C₂₇H₂₉NO₁₀

InChI: InChI=1S/C27H29NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3/t10-,14-,16-,17-,22+,27-/m0/s1

InChI key: InChIKey=STQGQHZAVUOBTE-VGBVRHCVSA-N

SMILES: O=C1C=2C=CC=C(OC)C2C(=O)C=3C(O)=C4C(=C(O)C13)CC(O)(C(=O)C)CC4OC5OC(C)C(O)C(N)C5

Sinonimi:

• (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
• (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside hydrochloride (1:1)
• (7S,9S)-9-Acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,l 1-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
• (7S,9S)-9-acetyl-6,9,11-trihydroxy-4-methoxy-7-tetrahydropyran-2-yloxy-8,10-dihydro-7H-tetracene-5,12-dione
• (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
• (8S-Cis)-8-Acetyl-10-((3-Amino-2,3,6-Trideoxy-Alpha-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-1-Methoxy-5,12-Naphthacenedione Hydrochloride
• (8S-Cis)-8-Acetyl-10-[(3-Amino-2,3,6-Trideoxy-Alpha-L-Lyxo-Hexopyrannosyl)Oxy]
• (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
• 3-Acetyl-1,2,3,4,6,11-Hexahydro-3,5,12-Trihydroxy-10-Methoxy-6,11-Dioxo-1-Naph
• 3-Acetyl-3,5,12-Trihydroxy-10-Methoxy-6,11-Dioxo-1,2,3,4,6,11-Hexahydrotetracen-1-Yl 3-Amino-2,3,6-Trideoxyhexopyranoside
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-
• 5,12-Naphthacenedione, 8-acetyl-10-[3-amino,2,3,6-trideoxy-α-L-lyoxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)
• Acetyladriamycin
• Ammonia
• Cerubidin
• D-Glucose, 2-deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-
• DaunoXome
• Daunoblastina
• Daunomycin Hydrochloride
• Daunomycine
• Daunorrubicina
• Daunorubicin
• Daunorubicine
• Daunorubicine Hydrochloride
• Fsl 0507
• Hydrate
• Hydrochloride
• Leukaemomycin C
• Leukaemomycin C Hydrochloride
• Methane
• Molecular Hydrogen
• Nsc 82151
• Nsc 83142
• Rp 13057
• Rubidomycin
• Rubomycin C
• (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
• Daunomycin

Daunorubicin-13C-d3 Trifluoroacetate

CAS: 20830-81-3

• Formula: C₂₆₁₃CH₂₆D₃NO₁₀·C₂HF₃O₂
• Peso molecolare: 531.54 114.02

Daunorubicin Hydrochloride

CAS: 20830-81-323541-50-6

• Formula: C₂₇H₂₉NO₁₀·HCl
• Purezza: >98.0%(N)
• Colore e forma: Orange to Red powder to crystal
• Peso molecolare: 563.98

Daunorubicin-13C,d3 (>85%)

CAS: 20830-81-3

• Formula: CC₂₆D₃H₂₆NO₁₀
• Purezza: >85%
• Colore e forma: Neat
• Peso molecolare: 531.53

Daunorubicin

CAS: 20830-81-3

Anthracycline antibiotic with potent anti-tumoral activity. The compound interferes with DNA replication and RNA transcription …

• Formula: C₂₇H₂₉NO₁₀
• Purezza: Min. 95%
• Peso molecolare: 527.52 g/mol