CAS 2098-66-0

Ciproterone

Descrizione:

Ciproterone è un antiandrogeno steroideo sintetico e progestinico, utilizzato principalmente nel trattamento di condizioni legate a livelli eccessivi di androgeni, come hirsutismo, acne e alcuni tipi di perdita di capelli nelle donne. È anche utilizzato nella terapia ormonale per donne transgender e nella gestione del cancro alla prostata. Chimicamente, Ciproterone è caratterizzato dalla sua capacità di inibire l'azione degli androgeni bloccando i recettori androgenici e riducendo la produzione di testosterone. Ha una formula molecolare che include carbonio, idrogeno e ossigeno, e la sua struttura presenta un nucleo di ciclopentanoperidrofenantrene tipico dei composti steroidei. Ciproterone viene somministrato per via orale o tramite iniezione, e i suoi effetti farmacologici includono proprietà antiandrogene, anti-infiammatorie e progestazionali. Gli effetti collaterali possono includere aumento di peso, cambiamenti dell'umore e potenziali impatti sulla funzione epatica, richiedendo monitoraggio durante il trattamento. In generale, Ciproterone è un composto significativo in endocrinologia e salute riproduttiva, dimostrando la complessa interazione degli ormoni nella fisiologia umana.

Formula: C₂₂H₂₇ClO₃

InChI: InChI=1/C22H27ClO3/c1-11(24)22(26)7-5-14-12-9-18(23)17-10-19(25)13-8-16(13)21(17,3)15(12)4-6-20(14,22)2/h9-10,12-16,26H,4-8H2,1-3H3/t12?,13-,14?,15?,16?,20+,21+,22+/m1/s1

InChI key: InChIKey=DUSHUSLJJMDGTE-ZJPMUUANSA-N

SMILES: C[C@]12[C@@]3([C@@](C3)(C(=O)C=C1C(Cl)=C[C@@]4([C@@]2(CC[C@@]5(C)[C@]4(CC[C@@]5(C(C)=O)O)[H])[H])[H])[H])[H]

Sinonimi:

• (1R,3aS,3bR,7aR,8aS,8bS,8cS,10aS)-1-acetyl-5-chloro-1-hydroxy-8b,10a-dimethyl-2,3,3a,3b,7a,8,8a,8b,8c,9,10,10a-dodecahydrocyclopenta[a]cyclopropa[g]phenanthren-7(1H)-one
• (1R,7aR,8aS)-1-acetyl-5-chloro-1-hydroxy-8b,10a-dimethyl-2,3,3a,3b,7a,8,8a,8b,8c,9,10,10a-dodecahydrocyclopenta[a]cyclopropa[g]phenanthren-7(1H)-one
• (1R,7aR,8bS,10aS)-1-acetyl-5-chloro-1-hydroxy-8b,10a-dimethyl-2,3,3a,3b,7a,8,8a,8b,8c,9,10,10a-dodecahydrocyclopenta[a]cyclopropa[g]phenanthren-7(1H)-one
• (1β,2β)-6-Chloro-1,2-dihydro-17-hydroxy-3′H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione
• 1,2α-Methylene-6-chloro-⁶-17α-hydroxyprogesterone
• 3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 6-chloro-1-beta,2-beta-dihydro-17-hydroxy-
• 3′H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 6-chloro-1,2-dihydro-17-hydroxy-, (1β,2β)-
• 3′H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 6-chloro-1β,2β-dihydro-17-hydroxy-
• 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteron
• 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteron [German]
• 6-Chloro-1,2α-methylene-4,6-pregnadien-17α-ol-3,20-dione
• 6-Chloro-17-hydroxy-1α,2α-methylenepregna-4,6-diene-3,20-dione
• 6-Chloro-6-dehydro-17α-hydroxy-1,2α-methyleneprogesterone
• Bay 94-8367
• Bay94-8367
• Ciproterona
• Ciproterona [INN-Spanish]
• Ciproterone
• Ciproterone [DCIT]
• Cyproteron
• Cyproterone [INN:BAN]
• Cyproteronum
• Cyproteronum [INN-Latin]
• Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-1α,2α-methylene-
• Sh 80881
• Sh 881
• Unii-E61Q31Ek2F
• Cyproterone
• Cyproterone USP/EP/BP
• 6-chloro-1b,2b-dihydro-17-hydroxy-3'h-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione
• Cyproterone Acetate IMpurity F (Cyproterone)
• Cyproterone Acetate EP Impurity F
• Cyproterone Acetate 427-51-0 /Base
• 6-chlor-delta(sup6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteron
• 6-Chloro-1β,2β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-4,6-diene-3,20-dione
• 3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 6-chloro-1,2-dihydro-17-hydroxy-, (1β,2β)-
• Cyproterone Acetate Impurity 6（Cyproterone Acetate EP Impurity F）
• Cyproterone Acetate Impurity F
• (1β,2β)-6-Chloro-1,2-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4
• Cyproterone-d5
• 1,2α-Methylene-6-chloro-6-17α-hydroxyprogesterone
• ro-17-hydroxy-
• 3’h-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione,6-chloro-1-beta,2-beta-dihyd
• Cyproterone Acetate EP Impurity F (Cyproterone)

Cyproterone Acetate EP Impurity F-d3 (Cyproterone-d3)

CAS: 2098-66-0

Formula: C₂₂H₂₄D₃ClO₃

Peso molecolare: 377.92

Ref: 4Z-C-2819

Cyproterone Acetate EP Impurity F (Cyproterone)

CAS: 2098-66-0

Formula: C₂₂H₂₇ClO₃

Colore e forma: Pale Yellow Solid

Peso molecolare: 374.91

Ref: 4Z-C-281

Cyproterone Acetate EP Impurity D

CAS: 2098-66-0

Formula: C₂₄H₃₁ClO₅

Colore e forma: Pale Yellow Solid

Peso molecolare: 434.96

Ref: 4Z-C-2817

Cyproterone

Prodotto controllato

CAS: 2098-66-0

Formula: C₂₂H₂₇ClO₃

Colore e forma: Neat

Peso molecolare: 374.90

Ref: 04-C11917000

Cyproterone-d5

CAS: 2098-66-0

Formula: C₂₂H₂₂D₅ClO₃

Peso molecolare: 379.94

Ref: 4Z-C-282

Cyproterone-d4

Prodotto controllato

CAS: 2098-66-0

Applications Labelled Cyproterone (C989090). An antiandrogen, suppresses Testosterone and its metabolites. Derivatives of Cyproterone are administered to patients suffering from hypersexuality and to help facilitate the sexual transformation of male-to-female transsexuals.
References Gracia, T., et al.: Toxicol. App. Pharmacol., 225, 142 (2007), Ahlin, G., et al.: J. Med. Chem., 51, 5932 (2008), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Bovee, T., et al.: J. Steroid Biochem. Mol. Biol., 118, 85 (2010),

Formula: C₂₂H₂₃D₄ClO₃

Colore e forma: Neat

Peso molecolare: 378.93

Ref: TR-C989092

Cyproterone

Prodotto controllato

CAS: 2098-66-0

Impurity Cyproterone Acetate EP Impurity F
Applications Cyproterone (Cyproterone Acetate EP Impurity F) is an antiandrogen, suppresses Testosterone and its metabolites. Derivatives of Cyproterone are administered to patients suffering from hypersexuality and to help facilitate the sexual transformation of male-to-female transsexuals.
References Gracia, T., et al.: Toxicol. App. Pharmacol., 225, 142 (2007), Ahlin, G., et al.: J. Med. Chem., 51, 5932 (2008), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Bovee, T., et al.: J. Steroid Biochem. Mol. Biol., 118, 85 (2010),

Formula: C₂₂H₂₇ClO₃

Colore e forma: Off White Solid

Peso molecolare: 374.9

Ref: TR-C989090

Cyproterone-13C2,d8

Prodotto controllato

CAS: 2098-66-0

Formula: C₂C₂₀D₈H₁₉ClO₃

Colore e forma: Neat

Peso molecolare: 384.936

Ref: TR-C989093

Cyproterone Acetate EP Impurity F

CAS: 2098-66-0

Formula: C₂₂H₂₇ClO₃

Peso molecolare: 374.9

Ref: ST-EA-CP-C148017

Cyproterone

CAS: 2098-66-0

Cyproterone, an anti-androgen, treats female hirsutism and acne, and is used palliatively in prostate cancer.

Formula: C₂₂H₂₇ClO₃

Colore e forma: Solid

Peso molecolare: 374.9

Ref: TM-T21016

Cyproterone

Prodotto controllato

CAS: 2098-66-0

Cyproterone is a steroidal anti-androgen that is used in the treatment of prostate cancer and other diseases. Cyproterone acetate (CPA) is an ester prodrug of cyproterone, which has been used as a contraceptive for more than 25 years. It binds to cytoplasmic receptors, blocking the effects of androgens on these receptors. CPA also inhibits transcriptional regulation by reducing the basal level of androgen receptor expression in target tissues. Cyproterone acetate has been shown to inhibit the growth of breast cancer cells through its ability to bind to and activate growth factor-β1 (GF-β1). CPA also has been shown to have positive effects on energy metabolism by regulating the activity of enzymes in this process. Cyproterone acetate is not active against many Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA).

Formula: C₂₂H₂₇ClO₃

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 374.9 g/mol

Ref: 3D-FC20763