CAS 2140-61-6

5-Metilcitidina

Descrizione:

5-Metilcitidina è un derivato nucleosidico della citidina, caratterizzato dalla presenza di un gruppo metile nella posizione 5 dell'anello pirimidinico. Questa modifica gioca un ruolo significativo in vari processi biologici, in particolare nella regolazione dell'espressione genica e nella stabilità dell'RNA. Si trova comunemente nelle molecole di RNA, specialmente in tRNA e rRNA, dove contribuisce all'integrità strutturale e alla funzione di queste biomolecole essenziali. La presenza del gruppo metile può influenzare l'interazione dell'RNA con le proteine e altri acidi nucleici, influenzando così processi cellulari come la traduzione e la trascrizione. 5-Metilcitidina è anche coinvolto nella regolazione epigenetica, poiché può essere un marcatore per i modelli di metilazione del DNA. In termini di proprietà fisiche, è tipicamente un solido cristallino bianco a bianco sporco, solubile in acqua e mostra stabilità in condizioni fisiologiche. La sua formula chimica è C₈H₁₁N₃O₅, ed è utilizzato in varie applicazioni di biochimica e biologia molecolare, inclusi studi sulle modifiche dell'RNA e sull'epigenetica.

Formula: C₁₀H₁₅N₃O₅

InChI: InChI=1S/C10H15N3O5/c1-4-2-13(10(17)12-8(4)11)9-7(16)6(15)5(3-14)18-9/h2,5-7,9,14-16H,3H2,1H3,(H2,11,12,17)/t5-,6-,7-,9-/m1/s1

InChI key: InChIKey=ZAYHVCMSTBRABG-JXOAFFINSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)C(C)=C2

Sinonimi:

• 4-amino-5-methyl-1-pentofuranosylpyrimidin-2(1H)-one
• Cytidine, 5-methyl-
• Nsc 363933
• 5-Methylcytidine
• 3: PN: US20060035254 PAGE: 63 claimed sequence

5-Methylcytidine

CAS: 2140-61-6

Formula: C₁₀H₁₅N₃O₅

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 257.25

Ref: 3B-M1931

5-Methylcytidine

CAS: 2140-61-6

Formula: C₁₀H₁₅N₃O₅

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 257.2432

Ref: IN-DA0034AT

5-Methylcytidine

CAS: 2140-61-6

Formula: C₁₀H₁₅N₃O₅

Purezza: (HPLC) ≥ 98.0%

Colore e forma: White to almost white powder

Peso molecolare: 257.24

Ref: 7W-GE4109

5-Methylcytidine

CAS: 2140-61-6

5-Methylcytidine

Purezza: ≥95%

Peso molecolare: 257.24g/mol

Ref: 54-BUP14699

Cytarabine EP Impurity G

CAS: 2140-61-6

Formula: C₁₀H₁₅N₃O₅

Peso molecolare: 257.25

Ref: 4Z-C-150030

5-Methylcytidine

CAS: 2140-61-6

5-Methylcytidine

Purezza: 98%

Peso molecolare: 257.25g/mol

Ref: 54-OR72458

5-Methylcytidine

CAS: 2140-61-6

5-Methylcytidine is a modified nucleoside derived from 5-methylcytosine and is a minor constituent of RNA as well as DNA for certain organisms.

Formula: C₁₀H₁₅N₃O₅

Purezza: 99.02% - 99.88%

Colore e forma: Solid

Peso molecolare: 257.24

Ref: TM-T5912

5-Methylcytidine

CAS: 2140-61-6

5-Methylcytidine is a nucleoside that is found in DNA and RNA. It is used in structural biology to probe the structure of DNA. 5-Methylcytidine binds to the enzyme methyl transferase, which catalyzes the transfer of a methyl group from S-adenosylmethionine to produce 5-methyluridine. This reaction occurs in long-term toxicity studies using primary cells, such as lymphocytes and fibroblasts. 5-Methylcytidine has been shown to inhibit tumour growth in mice by binding to nuclear dna polymerase and blocking transcription. The binding site for this drug on the polymerase is located at the same site as that for nucleoside analogues like azidothymidine (AZT) and zidovudine (AZT).

Formula: C₁₀H₁₅N₃O₅

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 257.24 g/mol

Ref: 3D-NM03720

5-Methylcytidine

CAS: 2140-61-6

M02111 - 5-Methylcytidine

Formula: C₁₀H₁₅N₃O₅

Purezza: 97%

Colore e forma: Solid, White - Very pale yellow powder

Peso molecolare: 257.246

Ref: 10-M02111

5-Methylcytidine

Prodotto controllato

CAS: 2140-61-6

Stability Hygroscopic
Applications 5-Methylcytidine is a derivative of Cytidine (C998300), found in ribonucleic acids of animals, plants and bacteria. 5-Methylcytidine is a nucleoside found in liver emulsion that can inhibit the growth of spontaneous tumors of mammary gland origin in mice. 5-Methylcytidine is one of many nucleosides that can be used as biomedical marker using liquid chromatography and ion trap mass spectrometry coupling.
References Kammerer, B., et al.: Anal. Biol. Chem., 382, 1017 (2005); Strong, L. and Matsunaga, H.: J. Surg. Oncol., 4, 528 (1972)

Formula: C₁₀H₁₅N₃O₅

Colore e forma: Neat

Peso molecolare: 257.24

Ref: TR-M294850

5-Methylcytidine

CAS: 2140-61-6

5-Methylcytidine is a methyltransferase enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to 5-methylcytosine. This reaction is essential for DNA replication and repair. 5-Methylcytidine has been shown to be an important factor in the regulation of mitochondrial functions, as well as other cellular processes such as protein synthesis, nuclear DNA replication, and tumor suppression. It also has been shown to inhibit the replication of murine sarcoma virus and Toll-like receptor. 5-Methylcytidine can be used in chemotherapy treatment against mouse tumors and murine sarcoma virus by preventing viral RNA synthesis with monoclonal antibodies.

Formula: C₁₀H₁₅N₃O₅

Peso molecolare: 257.24 g/mol

Ref: 3D-W-201877

Cytarabine EP Impurity G

CAS: 2140-61-6

Formula: C₁₀H₁₅N₃O₅

Peso molecolare: 257.2

Ref: ST-EA-CP-C163007