CAS 2140-71-8

2'-O-Metilguanosina

Descrizione:

2'-O-Metilguanosina è un nucleoside modificato che svolge un ruolo significativo in vari processi biologici, in particolare nel metabolismo dell'RNA. Consiste in una base di guanina attaccata a uno zucchero ribosio, che è ulteriormente metilato al gruppo idrossile 2′. Questa modifica è comunemente trovata nel tRNA e nell'rRNA, contribuendo alla stabilità e funzionalità di queste molecole. La presenza del gruppo metile migliora l'integrità strutturale dell'RNA, influenzando il suo ripiegamento e interazione con le proteine. 2'-O-Metilguanosina è anche coinvolto nella regolazione dell'espressione genica e può influenzare lo splicing e la traduzione dell'RNA. La sua formula chimica riflette la presenza di atomi di carbonio, idrogeno, azoto e ossigeno, caratteristici dei nucleosidi. Il composto è solubile in acqua ed espone proprietà tipiche dei nucleosidi, come la formazione di legami idrogeno e la partecipazione al pairing delle basi. A causa della sua importanza biologica, 2'-O-Metilguanosina è di interesse nella ricerca relativa alla biologia dell'RNA, alla terapia e allo sviluppo di farmaci basati sull'RNA.

Formula: C₁₁H₁₅N₅O₅

InChI: InChI=1/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1

InChI key: InChIKey=OVYNGSFVYRPRCG-KQYNXXCUSA-N

SMILES: O(C)[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](CO)[C@H]1O

Sinonimi:

• 1-Methylguanosine = 2-O-Methylguanosine
• Guanosine, 2′-O-methyl-
• 2′-O-Methylguanosine
• 2'-O-Methyl-D-guanosine

2'-O-Methylguanosine

CAS: 2140-71-8

Formula: C₁₁H₁₅N₅O₅

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 297.27

Ref: 3B-M2318

2'-O-Methylguanosine, 99%

CAS: 2140-71-8

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₁H₁₅N₅O₅

Purezza: 99%

Peso molecolare: 297.27

Ref: 02-J65770

2'-O-Methylguanosine

CAS: 2140-71-8

Formula: C₁₁H₁₅N₅O₅

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 297.2673

Ref: IN-DA00BHLE

2-Amino-9-((2R,3R,4R,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-Methoxytetrahydrofuran-2-Yl)-1H-Purin-6(9H)-One

CAS: 2140-71-8

2-Amino-9-((2R,3R,4R,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-Methoxytetrahydrofuran-2-Yl)-1H-Purin-6(9H)-One

Purezza: 98%

Peso molecolare: 297.27g/mol

Ref: 54-OR1010293

2’-OMe-Guanosine

CAS: 2140-71-8

2’-OMe-Guanosine

Purezza: ≥98%

Peso molecolare: 297.27g/mol

Ref: 54-BUP17632

2''-O-Methyl guanosine

CAS: 2140-71-8

Formula: C₁₁H₁₅N₅O₅

Purezza: ≥ 98.0%

Colore e forma: White to almost white powder or crystals

Peso molecolare: 297.27

Ref: 7W-GC3937

2'-O-Methylguanosine

CAS: 2140-71-8

Formula: C₁₁H₁₅N₅O₅

Peso molecolare: 297.27

Ref: 4Z-G-2429

2'-OMe-Guanosine

CAS: 2140-71-8

2'-OMe-Guanosine is a modified nucleoside produced by the action of tRNA guanosine-2'-o-methyltransferase. 2'-OMe-Guanosine has a certain pro-apoptotic effect.

Formula: C₁₁H₁₅N₅O₅

Purezza: 99.93%

Colore e forma: White Solid

Peso molecolare: 297.27

Ref: TM-T9726

2'-O-Methyl Guanosine-d3

Prodotto controllato

CAS: 2140-71-8

Applications 2'-O-Methyl Guanosine-d3 is a labeled analogue of 2'-O-Methyl Guanosine (M311825), which is a Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
References Eldrup, A.B., et al.: J. Med. Chem., 47, 2283 (2004), Shim, J., et al.: Antiviral Res., 243 (2003), Wang, M., et al.: J. Biol. Chem., 278, 9489 (2003),

Formula: C₁₁D₃H₁₂N₅O₅

Colore e forma: Neat

Peso molecolare: 300.29

Ref: TR-M311827

2'-O-Methyl Guanosine

Prodotto controllato

CAS: 2140-71-8

Applications Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
References Eldrup, A.B., et al.: J. Med. Chem., 47, 2283 (2004), Shim, J., et al.: Antiviral Res., 243 (2003), Wang, M., et al.: J. Biol. Chem., 278, 9489 (2003),

Formula: C₁₁H₁₅N₅O₅

Colore e forma: Neat

Peso molecolare: 297.27

Ref: TR-M311825

2'-O-Methylguanosine

CAS: 2140-71-8

2'-O-Methylguanosine is a nucleoside that contains a 2'-O-methyl group at the 2' position of the ribose. It is a component of many nucleic acids and is usually found as a minor component in RNA. 2'-O-Methylguanosine has been shown to be an inhibitor of DNA polymerase and an activator of RNA polymerase, which may be due to its ability to form hydrogen bonds with the phosphate backbone. This compound has also been shown to act as a competitive inhibitor for both wild-type and mutant bacterial strains, suggesting that it can inhibit DNA synthesis in bacteria by binding to the enzyme's active site. 2'-O-Methylguanosine is present in relatively high concentrations in tissues, such as liver and muscle, where it is involved in metabolism or energy production. The optimum concentration for detection by analytical methods varies depending on the type of detector used.

Formula: C₁₁H₁₅N₅O₅

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 297.27 g/mol

Ref: 3D-NM02941

2′-O-Methylguanosine

CAS: 2140-71-8

Formula: C₁₁H₁₅N₅O₅

Purezza: 98%

Colore e forma: Solid, White to almost white powder

Peso molecolare: 297.271

Ref: 10-F225192