CAS 2140-73-0

1-Metilinosina

Descrizione:

1-Metilinosina è un derivato di nucleoside caratterizzato dalla presenza di un gruppo metile nella posizione N1 della base purinica, inosina. È un composto che si trova naturalmente in vari sistemi biologici, in particolare nell'RNA. La struttura molecolare di 1-Metilinosina consiste in uno zucchero ribosio legato alla base purinica, il che contribuisce al suo ruolo nei processi cellulari. Questo composto è coinvolto nella regolazione dell'espressione genica e può influenzare vari percorsi metabolici. Il suo unico schema di metilazione può influenzare la stabilità e la funzione delle molecole di RNA, impattando la sintesi proteica e la segnalazione cellulare. 1-Metilinosina è anche di interesse nella ricerca relativa all'epitranscrittomica, dove le modifiche all'RNA vengono studiate per la loro importanza biologica. Il numero CAS 2140-73-0 identifica in modo univoco questo composto nelle banche dati chimiche, facilitando il suo studio e applicazione in vari campi scientifici, tra cui biochimica e biologia molecolare.

Formula: C₁₁H₁₄N₄O₅

InChI: InChI=1S/C11H14N4O5/c1-14-3-13-9-6(10(14)19)12-4-15(9)11-8(18)7(17)5(2-16)20-11/h3-5,7-8,11,16-18H,2H2,1H3/t5-,7-,8-,11-/m1/s1

InChI key: InChIKey=WJNGQIYEQLPJMN-IOSLPCCCSA-N

SMILES: O[C@H]1[C@H](N2C3=C(N=C2)C(=O)N(C)C=N3)O[C@H](CO)[C@H]1O

Sinonimi:

• 2140-73-0
• Inosine, 1-methyl-
• N¹-Methylinosine
• 1-Methylinosine
• N1-Methylinosine

Inosine, 1-methyl

CAS: 2140-73-0

Formula: C₁₁H₁₄N₄O₅

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 282.2527

Ref: IN-DA00C2V5

(2R,3R,4S,5R)-2-(6-Hydroxy-1-Methyl-1H-Purin-9(2H)-Yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol

CAS: 2140-73-0

(2R,3R,4S,5R)-2-(6-Hydroxy-1-Methyl-1H-Purin-9(2H)-Yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol

Purezza: 99%

Peso molecolare: 282.25g/mol

Ref: 54-OR1023913

1-Methylinosine

CAS: 2140-73-0

1-Methylinosine

Purezza: ≥98%

Peso molecolare: 282.25g/mol

Ref: 54-BUP10688

1-Methylinosine

CAS: 2140-73-0

Formula: C₁₁H₁₄N₄O₅

Purezza: >98.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 282.26

Ref: 3B-M3670

1-Methylinosine

CAS: 2140-73-0

1-Methylinosine (N1-Methylinosine) is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA and has a role as a metabolite.

Formula: C₁₁H₁₄N₄O₅

Purezza: 99.7%

Colore e forma: Solid

Peso molecolare: 282.25

Ref: TM-T19083

1-Methyl-Inosine

Prodotto controllato

CAS: 2140-73-0

Applications 1-Methyl-Inosine is a modified nucleoside which is present in higher concentrations in the urinary excretion of patients afflicted with breast cancer. It acts a a biomarker for diagnosis of the disease.
References Frickenschmidt, A. et al.: Biomark., 13, 435 (2008); Studzinska, S. et al.: J. Chrom. B. Tech. Biomed. Life Sci., 887, 93 (2012);

Formula: C₁₁H₁₄N₄O₅

Colore e forma: Neat

Peso molecolare: 282.25

Ref: TR-M313600

N1-Methylinosine

Prodotto controllato

CAS: 2140-73-0

N1-Methylinosine is a purine derivative that can be used as an imaging agent for the detection of autoimmune disorders. It has been shown to form stable complexes with proteins and human serum proteins, which have been detected in urine samples. N1-Methylinosine has also been used in clinical studies to measure disease activity in patients with rheumatoid arthritis and chronic kidney disease. This drug is activated by catalysis to produce a fluorescent product that can be detected using nmr spectroscopy. N1-Methylinosine is able to bind to autoantibodies and activate markers of chronic inflammation, such as nuclear factor kappa B (NF-κB) and tumor necrosis factor alpha (TNFα).
N1-Methylinosine has also been shown to inhibit breast cancer cell growth and reduce the severity of chronic kidney disease.

Formula: C₁₁H₁₄N₄O₅

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 282.25 g/mol

Ref: 3D-FM163160

Inosine, 1-methyl

CAS: 2140-73-0

Purezza: 97%

Peso molecolare: 282.256012

Ref: 10-F863466

1-Methyl-Inosine-d3

Prodotto controllato

CAS: 2140-73-0

Applications 1-Methyl-Inosine-d3 is the isotope labelled analog of 1-Methyl-Inosine (M313600); a modified nucleoside which is present in higher concentrations in the urinary excretion of patients afflicted with breast cancer. It acts as a biomarker for diagnosis of the disease.
References Frickenschmidt, A. et al.: Biomark., 13, 435 (2008); Studzinska, S. et al.: J. Chrom. B. Tech. Biomed. Life Sci., 887, 93 (2012)

Formula: C₁₁D₃H₁₁N₄O₅

Colore e forma: Neat

Peso molecolare: 285.271

Ref: TR-M313602