CAS 220620-09-7

Tigeciclina

Descrizione:

Tigeciclina è un antibiotico glicilciclina ad ampio spettro, strutturalmente correlato alle tetracicline, e viene utilizzato principalmente per trattare varie infezioni batteriche, in particolare quelle causate da organismi multiresistenti. Mostra un meccanismo d'azione unico inibendo la sintesi proteica batterica attraverso il legame con la subunità ribosomiale 30S, impedendo così l'incorporazione di amminoacidi nei peptidi. Tigeciclina è efficace contro un'ampia gamma di batteri Gram-positivi e Gram-negativi, comprese alcune ceppi di Staphylococcus aureus resistente alla meticillina (MRSA) e Enterococcus resistente alla vancomicina (VRE). Viene tipicamente somministrato per via endovenosa ed è indicato per infezioni complicate della pelle e delle strutture cutanee, infezioni intra-addominali complicate e polmonite acquisita in comunità. Tigeciclina ha una biodisponibilità orale relativamente bassa, motivo per cui si preferisce la somministrazione parenterale. I suoi effetti collaterali possono includere nausea, vomito e possibile elevazione degli enzimi epatici. A causa della sua ampia attività ed efficacia contro ceppi resistenti, Tigeciclina gioca un ruolo cruciale nel trattamento di infezioni gravi, sebbene il suo uso sia spesso riservato a casi specifici per mitigare il rischio di sviluppo di resistenza.

Formula: C₂₉H₃₉N₅O₈

InChI: InChI=1S/C29H39N5O8/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35)/t12-,14-,21-,29-/m0/s1

InChI key: InChIKey=FPZLLRFZJZRHSY-HJYUBDRYSA-N

SMILES: O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C(C3)=C(N(C)C)C=C(NC(CNC(C)(C)C)=O)C4O)[H])[H]

Sinonimi:

• 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-[[[(1,1-dimethylethyl)amino]acetyl]amino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-
• GAR 936
• 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-[[2-[(1,1-dimethylethyl)amino]acetyl]amino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-
• WAY-GAR 936
• (4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-9-[[2-[(1,1-dimethylethyl)amino]acetyl]amino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide

Tigecycline

CAS: 220620-09-7

Formula: C₂₉H₃₉N₅O₈

Purezza: >98.0%(HPLC)

Colore e forma: Light yellow to Brown powder to crystal

Peso molecolare: 585.66

Ref: 3B-T3589

TIGECYCLINE FOR SYSTEM SUITABILITY CRS

CAS: 220620-09-7

TIGECYCLINE FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0001940

TIGECYCLINE CRS

CAS: 220620-09-7

TIGECYCLINE CRS

Ref: 41-Y0001961

Tigecycline

CAS: 220620-09-7

Tetracyclines and their derivatives; salts thereof

Formula: C₂₉H₃₉N₅O₈

Colore e forma: Orange Powder

Peso molecolare: 585.27986

Ref: 45-1667643

(4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-9-[[2-[(1,1-dimethylethyl)amino]acetyl]amino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide

CAS: 220620-09-7

Formula: C₂₉H₃₉N₅O₈

Purezza: 96%

Colore e forma: Solid

Peso molecolare: 585.6487

Ref: IN-DA003UT8

Tigecycline

CAS: 220620-09-7

Tigecycline (GAR-936), a broad-spectrum glycylcycline, disrupts protein synthesis by binding the 30S ribosomal subunit.

Formula: C₂₉H₃₉N₅O₈

Purezza: 98.81% - >99.99%

Colore e forma: Powder

Peso molecolare: 585.65

Ref: TM-T1569

Tigecycline

CAS: 220620-09-7

Tigecycline

Purezza: ≥98%

Peso molecolare: 585.65g/mol

Ref: 54-BUP15444

Tigecycline

CAS: 220620-09-7

Formula: C₂₉H₃₉N₅O₈

Colore e forma: Orange Solid

Peso molecolare: 585.66

Ref: 4Z-T-109001

Tigecycline

CAS: 220620-09-7

Colore e forma: Neat

Ref: 86-MM3343.00

Tigecycline

Prodotto controllato

CAS: 220620-09-7

Formula: C₂₉H₃₉N₅O₈

Colore e forma: Neat

Peso molecolare: 585.65

Ref: 04-C17577000

Tigecycline

CAS: 220620-09-7

Stability Light Sensitive
Applications A glycylcycline antibiotic, used to treat infection by drug resistant bacteria such as Staphylococcus aureus (Staph aureus) and Acinetobacter baumannii.
References Lim, T., et al.: J. Antibiotics, 62, 675 (2009), Presterl, E., et al.: Antimicrob. Agents Chemother., 53, 3205 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),

Formula: C₂₉H₃₉N₅O₈

Colore e forma: Orange

Peso molecolare: 585.65

Ref: TR-T440015

Tigecycline

CAS: 220620-09-7

Inhibitor of protein synthesis; glycylcycline class

Formula: C₂₉H₃₉N₅O₈

Purezza: Min. 98 Area-%

Colore e forma: Orange Powder

Peso molecolare: 585.65 g/mol

Ref: 3D-AT10818

Tigecycline, Antibiotic for Culture Media Use Only

CAS: 220620-09-7

Tigecycline is an antibiotic specifically tailored for use in culture media, which is derived from glycylcycline, a structural analogue of minocycline. Its mode of action involves binding to the 30S ribosomal subunit, thereby inhibiting protein synthesis in a broad spectrum of Gram-positive and Gram-negative bacteria. This action is distinct and not easily circumvented by common resistance mechanisms, such as efflux or ribosomal protection proteins, making tigecycline an effective agent in controlling bacterial contamination during microbiological studies.

Formula: C₂₉H₃₉N₅O₈

Purezza: Min. 95 Area-%

Peso molecolare: 585.65 g/mol

Ref: 3D-Q-101396