CAS 221877-54-9

Zotarolimus

Descrizione:

Zotarolimus, con il numero CAS 221877-54-9, è un composto macrolide sintetico che appartiene alla classe degli agenti immunosoppressori. Viene utilizzato principalmente nel campo medico come rivestimento per stent rilasciante farmaci per prevenire la restenosi nelle arterie coronarie dopo l'angioplastica. Zotarolimus agisce inibendo la proliferazione delle cellule muscolari lisce e modulando la risposta immunitaria, il che aiuta a ridurre il rischio di ostruzione arteriosa. Il composto presenta un meccanismo d'azione simile a quello del sirolimus, mirando alla via del bersaglio mammifero della rapamicina (mTOR), che è cruciale per la crescita e il metabolismo cellulare. Zotarolimus è caratterizzato dalla sua natura lipofila, che migliora la sua capacità di aderire alle superfici degli stent e di rilasciarsi gradualmente nel tempo. La sua farmacocinetica prevede una emivita relativamente lunga, consentendo effetti terapeutici sostenuti. I profili di sicurezza ed efficacia sono stati stabiliti attraverso studi clinici, rendendolo uno strumento prezioso nella cardiologia interventistica. Tuttavia, come tutti i farmaci, può avere effetti collaterali e controindicazioni potenziali che devono essere considerati nella pratica clinica.

Formula:C₅₂H₇₉N₅O₁₂

InChI:InChI=1S/C52H79N5O12/c1-31-16-12-11-13-17-32(2)43(65-8)28-39-21-19-37(7)52(64,69-39)49(61)50(62)56-23-15-14-18-41(56)51(63)68-44(34(4)26-38-20-22-40(45(27-38)66-9)57-30-53-54-55-57)29-42(58)33(3)25-36(6)47(60)48(67-10)46(59)35(5)24-31/h11-13,16-17,25,30-31,33-35,37-41,43-45,47-48,60,64H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,32-17+,36-25+/t31-,33-,34-,35-,37-,38+,39+,40+,41+,43+,44+,45-,47-,48+,52-/m1/s1

InChI key:InChIKey=CGTADGCBEXYWNE-JUKNQOCSSA-N

SMILES:O(C)[C@H]1[C@](CC[C@@H](C[C@@H](C)[C@]2(OC(=O)[C@]3(N(C(=O)C(=O)[C@]4(O)O[C@](C[C@H](OC)\C(\C)=C\C=C\C=C\[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)\C(\C)=C\[C@@H](C)C(=O)C2)(CC[C@H]4C)[H])CCCC3)[H])[H])C1)(N5C=NN=N5)[H]

Sinonimi:

(42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin
42-(1-Tetrazolyl)rapamycin
A 179578
Abt 578
Endeavor
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Resolute
Unii-H4gxr80ize
Zotarolimus
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
ABT-578;A-179578;ABT578;A179578;ABT 578;A 179578
(42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin Zotarolimus(ABT-578) A 179578 Resolute
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
ZotaroliMus(ABT-578)
Zotarolimus, &gt
ZotaroliMus, >90%
ZOTAROLIMUS USP/EP/BP
ZOTAROLIMUS Impurities
ZotaroliMus API
42-deoxy-42-(1H-tetrazol-1-yl)-(42S)-Rapamycin
CS-1162
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Vedi altri sinonimi

Purezza (%)

100

7 prodotti.

+ Info
Zotarolimus
CAS:
- 221877-54-9
Formula:C₅₂H₇₉N₅O₁₂
Purezza:95%
Colore e forma:Solid
Peso molecolare:966.2100
Ref: IN-DA00BF84
1mg
96,00€
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5mg
162,00€
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25mg
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Zotarolimus
CAS:
- 221877-54-9
Zotarolimus
Purezza:≥95%
Peso molecolare:966.21g/mol
Ref: 54-BUP04934
1mg
53,00€
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5mg
113,00€
IVA esclusa
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10mg
186,00€
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Zotarolimus
CAS:
- 221877-54-9
Formula:C₅₂H₇₉N₅O₁₂
Colore e forma:Off-White Solid
Peso molecolare:966.23
Ref: 4Z-Z-141
5mg
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10mg
698,00€
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25mg
1.153,00€
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50mg
2.002,00€
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100mg
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Zotarolimus
CAS:
- 221877-54-9
Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).
Formula:C₅₂H₇₉N₅O₁₂
Purezza:95% - 98.01%
Colore e forma:Solid
Peso molecolare:966.21
Ref: TM-T6033
+ Info
Zotarolimus-d3
CAS:
- 221877-54-9
Formula:C₅₂H₇₆D₃N₅O₁₂
Peso molecolare:969.23
Ref: 4Z-Z-142
5mg
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10mg
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25mg
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50mg
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100mg
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Zotarolimus
CAS:
- 221877-54-9
Inhibitor of immunophilin FKBP12 and mTOR signalling with immunosuppressant activity. Zotarolimus inhibits proliferation of endothelial cells and smooth muscle cells and is employed in vascular interventional therapies.
Formula:C₅₂H₇₉N₅O₁₂
Purezza:Min. 95%
Colore e forma:White Powder
Peso molecolare:966.21 g/mol
Ref: 3D-FZ28788
2mg
135,00€
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5mg
166,00€
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10mg
224,00€
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25mg
382,00€
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Zotarolimus-d3, >90% (contains d0)
Prodotto controllatoSi prega di notare che in alcuni Paesi questo è un prodotto controllato e deve essere trattato in conformità alle normative vigenti. Si tenga presente che ciò potrebbe comportare spese e documentazione aggiuntive.
CAS:
- 221877-54-9
Formula:C₅₂D₃H₇₆N₅O₁₂
Colore e forma:Neat
Peso molecolare:969.229
Ref: TR-Z700802
2500µg
1.509,00€
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