CAS 22260-51-1

Mesilato di bromocriptina

Descrizione:

Mesilato di bromocriptina è un composto sintetico utilizzato principalmente come agonista della dopamina nel trattamento di varie condizioni mediche, tra cui il morbo di Parkinson, l'iperprolattinemia e alcuni tipi di acromegalia. È derivato da alcaloidi dell'ergot e funziona stimolando i recettori della dopamina, in particolare i recettori D2, il che aiuta a regolare i livelli ormonali e migliorare il controllo motorio. La forma di sale mesilato ne migliora la solubilità e la stabilità, rendendolo adatto per formulazioni farmaceutiche. Mesilato di bromocriptina è tipicamente somministrato per via orale ed è noto per la sua relativamente rapida assorbimento e biodisponibilità. Gli effetti collaterali comuni possono includere nausea, vertigini e affaticamento, riflettendo la sua attività sul sistema nervoso centrale. Il composto è classificato come un farmaco da prescrizione e deve essere utilizzato sotto supervisione medica a causa delle potenziali interazioni con altri farmaci e controindicazioni in alcune popolazioni di pazienti. La sua struttura chimica include un atomo di bromo, che contribuisce alle sue proprietà farmacologiche, ed è spesso studiato per i suoi effetti sulle funzioni neuroendocrine.

Formula: C₃₂H₄₀BrN₅O₅·CH₄O₃S

InChI: InChI=1S/C32H40BrN5O5.CH4O3S/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18;1-5(2,3)4/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39);1H3,(H,2,3,4)/t18-,23-,24+,25+,31-,32+;/m1./s1

InChI key: InChIKey=NOJMTMIRQRDZMT-GSPXQYRGSA-N

SMILES: O[C@]12N(C(=O)[C@@](NC(=O)[C@@H]3C=C4C=5C=6C(C[C@]4(N(C)C3)[H])=C(Br)NC6C=CC5)(C(C)C)O1)[C@@H](CC(C)C)C(=O)N7[C@]2(CCC7)[H].S(C)(=O)(=O)O

Sinonimi:

• (+)-Bromocriptine methanesulfonate
• (5'Alpha)-2-Bromo-12'-Hydroxy-5'-(2-Methylpropyl)-3',6',18-Trioxo-2'-(Propan-2-Yl)Ergotaman Methanesulfonate (1:1)
• (5Xi,5'Alpha)-2-Bromo-12'-Hydroxy-2'-(1-Methylethyl)-5'-(2-Methylpropyl)-3',6',18-Trioxoergotaman Methanesulfonate (Salt)
• (8Xi,12'Xi)-2-Bromo-12'-Hydroxy-2'-(1-Methylethyl)-5'-(2-Methylpropyl)-3',6',18-Trioxoergotaman Methanesulfonate (Salt)
• 2-bromo-A-ergocryptine methanesulfonate salt
• 8H-Oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine, ergotaman-3′,6′,18-trione deriv.
• Bagren
• Bromocriptine Mesylate
• Bromocryptine mesylate
• Bromocryptine methanesulfonate
• Cb 154
• Cycloset
• Ergocryptine, 2-bromo-, monomethanesulfonate (salt)
• Ergotaman-3′,6′,18-trione, 2-bromo-12′-hydroxy-2′-(1-methylethyl)-5′-(2-methylpropyl)-, (5α)-, methanesulfonate (1:1)
• Ergotaman-3′,6′,18-trione, 2-bromo-12′-hydroxy-2′-(1-methylethyl)-5′-(2-methylpropyl)-, (5′α)-, monomethanesulfonate (salt)
• Indolo[4,3-fg]quinoline, ergotaman-3′,6′,18-trione deriv.
• Parlodel

Bromocriptine Mesilate

CAS: 22260-51-1

Colore e forma: Neat

Ref: 61-FOR1159.00

Bromocriptine mesilate

CAS: 22260-51-1

Bromocriptine mesilate

Formula: C₃₂H₄₀BrN₅O₅

Purezza: 86.2%

Colore e forma: Off-White

Peso molecolare: 653.22128

Ref: 47-50

BROMOCRIPTINE MESILATE FOR SYSTEM SUITABILITY CRS

CAS: 22260-51-1

BROMOCRIPTINE MESILATE FOR SYSTEM SUITABILITY CRS

Formula: C₃₃H₄₄BrN₅O₈S

Peso molecolare: 750.7002

Ref: 41-Y0000677

BROMOCRIPTINE MESILATE CRS

CAS: 22260-51-1

BROMOCRIPTINE MESILATE CRS

Formula: C₃₃H₄₄BrN₅O₈S

Colore e forma: Crystalline Powder. White. Whitish. Powder.

Peso molecolare: 750.7002

Ref: 41-B1150000

Bromocriptine Mesylate

CAS: 22260-51-1

Alkaloids of rye ergot and their derivatives; salts thereof, nesoi

Formula: C₃₂H₄₀BrN₅O₅·CH₄O₃S

Colore e forma: White Off-White Powder

Peso molecolare: 749.2094

Ref: 45-1076501

Bromocriptine mesylate

CAS: 22260-51-1

Formula: C₃₃H₄₄BrN₅O₈S

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 750.7002

Ref: IN-DA007P10

Bromocriptine Mesylate

CAS: 22260-51-1

Formula: C₃₂H₄₀BrN₅O₅·CH₄O₃S

Colore e forma: White To Off-White Solid

Peso molecolare: 654.61 96.10

Ref: 4Z-B-333

Bromocriptine mesylate

CAS: 22260-51-1

Bromocriptine mesylate

Peso molecolare: 750.7g/mol

Ref: 54-BI12183

Bromocriptine mesylate

CAS: 22260-51-1

Bromocriptine mesylate

Purezza: ≥98%

Peso molecolare: 750.7g/mol

Ref: 54-BUP17549

Bromocriptine Mesilate

Prodotto controllato

CAS: 22260-51-1

Formula: C₃₂H₄₀BrN₅O₅·CH₄O₃S

Colore e forma: Neat

Peso molecolare: 750.70

Ref: 86-MM1159.00

Bromocriptine mesylate

CAS: 22260-51-1

Bromocriptine mesylate (CB-154) is a potent dopamine receptor agonist that binds the D2 receptor with highest affinity (Ki = 2.5 nM)

Formula: C₃₃H₄₄BrN₅O₈S

Purezza: 99.85% - 99.96%

Colore e forma: White Solid

Peso molecolare: 750.7

Ref: TM-T5842

Bromocryptine mesylate

CAS: 22260-51-1

Formula: C₃₂H₄₀BrN₅O₅·CH₄SO₃

Purezza: 98.0 - 102.0 % (anhydrous basis)

Colore e forma: White powder

Peso molecolare: 750.70

Ref: 7W-GP6938

Bromocriptine mesylate

Prodotto controllato

CAS: 22260-51-1

Dopamine (D2) agonist; inhibits neuronal NOS enzyme

Formula: C₃₂H₄₀BrN₅O₅•CH₄O₃S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 750.7 g/mol

Ref: 3D-FB19032

Bromocriptine mesylate - Bio-X ™

Prodotto controllato

CAS: 22260-51-1

Bromocriptine is a dopamine D2 receptor agonist that is used for the treatment of galactorrhoea which is due to hyperprolactinemia and other prolactin-related conditions. This drug is an ergot alkaloid derivative that inhibits prolactin secretion. Additionally, it can be used to management signs and symptoms of Parkinsonian syndrome. Research has indicated this drug for pulmonary fibrosis as well.

Formula: C₃₃H₄₄BrN₅O₈S

Purezza: Min. 99 Area-%

Colore e forma: Powder

Peso molecolare: 750.7 g/mol

Ref: 3D-BB164266

2-Bromo α-Ergocryptine Mesylate

Prodotto controllato

CAS: 22260-51-1

Applications The dopamine receptors play important role in cognition, memory, learning, and motor control (1). These receptors have been implicated as a therapeutic target for many psychiatric and neurological disorders. 2-Bromo-α-Ergocryptine is a dopamine receptor agonist and a derivative of the ergotoxin group of ergot alkaloids (2). It is also a prolactin inhibitor (3).
References (1) Ptácek, R., et al.: Med Sci Monit. 17, RA215 (2011) (2) Lieberman, A. N. and Goldstein, M.: Pharmacol Rev. 37, 217 (1985) (3) Nazli, K., et al.: Br J Clin Pract. 43, 322 (1989)

Formula: C₃₂H₄₀BrN₅O₅·CH₄O₃S

Colore e forma: White To Off-White

Peso molecolare: 750.70

Ref: TR-B682600