CAS 22720-35-0

6-bromo-2-naftil B-D-glucuronide

Descrizione:

Il 6-bromo-2-naftile β-D-glucuronide è un composto chimico che funge da coniugato di glucuronide, una modifica comune nel metabolismo dei farmaci e nei processi di disintossicazione. Questo composto presenta un sistema ad anello naftalenico sostituito nella posizione 6 con un atomo di bromo, aumentando la sua lipofilia e potenzialmente influenzando la sua attività biologica. Il gruppo β-D-glucuronide deriva dall'acido glucuronico, noto per il suo ruolo nell'aumentare la solubilità dei composti idrofobici, facilitando la loro escrezione dal corpo. Questo composto è spesso utilizzato nella ricerca biochimica, in particolare negli studi che coinvolgono l'attività enzimatica, come la glucuronidazione, catalizzata dalle UDP-glucuronosiltransferasi. Le sue caratteristiche strutturali contribuiscono alla sua reattività e interazioni con vari sistemi biologici. Come per molti composti organici sintetici, è necessario consultare i dati di sicurezza e seguire le procedure di manipolazione appropriate per mitigare eventuali rischi potenziali associati al suo utilizzo.

Formula: C₁₆H₁₅BrO₇

InChI: InChI=1/C16H15BrO7/c17-9-3-1-8-6-10(4-2-7(8)5-9)23-16-13(20)11(18)12(19)14(24-16)15(21)22/h1-6,11-14,16,18-20H,(H,21,22)/t11-,12-,13+,14-,16+/m0/s1

InChI key: InChIKey=TYDGGWYIJKMLEO-JHZZJYKESA-N

SMILES: O(C1=CC2=C(C=C1)C=C(Br)C=C2)[C@@H]3O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]3O

Sinonimi:

• 6-Bromo-2-naphthalenyl β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid
• 6-Bromo-2-naphthyl β-<span class="text-smallcaps">D</span>-glucopyranosiduronide
• 6-Bromo-2-naphthyl β-<span class="text-smallcaps">D</span>-glucuronide
• 6-bromo-2-naphthyl beta-D-glucopyranosiduronic acid
• 6-bromonaphthalen-2-yl beta-D-glucopyranosiduronic acid
• Glucopyranosiduronic acid, 6-bromo-2-naphthyl
• Glucopyranosiduronic acid, 6-bromo-2-naphthyl, β-<span class="text-smallcaps">D</span>-
• β-<span class="text-smallcaps">D</span>-Glucopyranosiduronic acid, 6-bromo-2-naphthalenyl
• β-D-Glucopyranosiduronic acid, 6-bromo-2-naphthalenyl
• Glucopyranosiduronic acid, 6-bromo-2-naphthyl, β-D-
• 6-Bromo-2-naphthalenyl β-D-glucopyranosiduronic acid
• 6-Bromo-2-naphthyl β-D-glucuronide
• 6-Bromo-2-naphtyl β-D-glucopyranosiduronic acid
• (2S,3S,4S,5R,6S)-6-((6-Bromonaphthalen-2-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
• 6-BROMO-2-NAPHTHYL-BETA-D-GLUCURONIDE
• 6-Bromo-2-naphthalenyl beta-D-glucopyranosiduronic acid
• (2S,3S,4S,5R,6S)-6-(6-bromonaphthalen-2-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
• 6-BROMO-2-NAPHTHYL-BETA-D-GLUCURONIC ACID
• 6-BROMO-2-NAPHTHYL-BETA-D-GLUCURONIDE USP/EP/BP
• 6-Bromo-2-naphthyl β-D-glucopyranosiduronic acid
• Einecs 245-176-1
• beta-D-6-Bromo-2-naphthyl glucopyranosiduronic acid
• (6-Bromonaphthalen-2-yl)β-D-glucopyranosiduronic acid

6-Bromo-2-naphthyl-β-d-glucuronide

CAS: 22720-35-0

Formula: C₁₆H₁₅BrO₇

Purezza: 95%

Peso molecolare: 399.1901

Ref: IN-DA00BDVR

6-Bromo-2-naphthyl b-D-glucuronide

CAS: 22720-35-0

Ref: 7W-GC6646

6-Bromo-2-naphthyl b-D-glucuronide

CAS: 22720-35-0

6-Bromo-2-naphthyl beta-D-glucuronide is a substrate for beta-glucuronidase, an enzyme involved in detoxification and bacterial metabolism. Upon enzymatic hydrolysis, it releases 6-bromo-2-naphthol, which forms a detectable dye when reacted with diazonium salts. This compound is widely used in microbiology to detecting E. coli in water testing and histochemical staining. 6-Bromo-2-naphthyl beta-D-glucuronide is also been used in cancer research studies. It has been found that some tumors are related to a high activity of beta-glucuronidase, responsible to reactivate the carcinogens and promote tumor progression, developing a drug resistance to chemotherapy.

Formula: C₁₆H₁₅BrO₇

Purezza: Min 97%

Colore e forma: White Off-White Powder

Peso molecolare: 399.2 g/mol

Ref: 3D-EB03245