CAS 23180-57-6

Paeoniflorina

Descrizione:

Paeoniflorina è un composto naturale estratto principalmente dalle radici della pianta di peonia, in particolare Paeonia lactiflora. È classificato come un glicoside monoterpenico ed è noto per le sue varie proprietà farmacologiche. Paeoniflorina mostra effetti anti-infiammatori, analgesici e neuroprotettivi, rendendolo di interesse nella medicina tradizionale e nella farmacologia moderna. Il composto è spesso studiato per le sue potenziali applicazioni terapeutiche in condizioni come dolore, ansia e malattie neurodegenerative. In termini di struttura chimica, Paeoniflorina è composto da una porzione di glucosio legata a un composto fenolico, che contribuisce alla sua attività biologica. È generalmente solubile in acqua e mostra stabilità in diverse condizioni di pH. Inoltre, è stato dimostrato che Paeoniflorina modula diverse vie di segnalazione, aumentando il suo potenziale come agente terapeutico. Il suo profilo di sicurezza è generalmente favorevole, ma sono necessarie ulteriori ricerche per comprendere appieno i suoi meccanismi d'azione e i potenziali effetti collaterali.

Formula: C₂₃H₂₈O₁₁

InChI: InChI=1S/C23H28O11/c1-20-9-22(29)13-7-23(20,32-18-16(27)15(26)14(25)12(8-24)31-18)21(13,19(33-20)34-22)10-30-17(28)11-5-3-2-4-6-11/h2-6,12-16,18-19,24-27,29H,7-10H2,1H3/t12-,13-,14-,15+,16-,18+,19-,20+,21+,22-,23+/m1/s1

InChI key: InChIKey=YKRGDOXKVOZESV-WRJNSLSBSA-N

SMILES: C(OC(=O)C1=CC=CC=C1)[C@@]23[C@@]4(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@@]6(C)O[C@@]2(O[C@@](O)([C@@]3(C4)[H])C6)[H]

Sinonimi:

• (1aR,2S,3aR,5R,5aR,5bS)-5b-[(Benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl β-<span class="text-smallcaps">D</span>-glucopyranoside
• 2,5-Methano-1H-3,4-dioxacyclobuta[cd]pentalene, β-<span class="text-smallcaps">D</span>-glucopyranoside deriv.
• Nsc 178886
• Paeoniflorin
• Peoniflorin
• β-<span class="text-smallcaps">D</span>-Glucopyranoside, (1aR,2S,3aR,5R,5aR,5bS)-5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl
• β-<span class="text-smallcaps">D</span>-Glucopyranoside, 5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1aα,2β,3aα,5α,5aα,5bα)]-
• β-D-Glucopyranosid, 5b-[(Benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1aα,2β,3aα,5α,5aα,5ba)]-
• β-D-Glucopyranoside, 5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1aα,2β,3aα,5α,5aα,5bα)]-
• β-D-glucopiranosido, 5b-[(benzoiloxi)metil]tetrahidro-5-hidroxi-2-metil-2,5-metano-1H-3,4-dioxaciclobuta[cd]pentalen-1a(2H)-il, [1aR-(1aα,2β,3aα,5α,5aα,5bα)]-
• β-D-glucopyrannoside, [(benzoyloxy)methyl]-5b tetrahydrohydroxy-5 methyl-2 methano-2,5 1H-dioxacyclo-3,4 buta[cd]pentalenyl 1a(2H), [1aR-(1aα,2β,3aα,5α,5aα,5bα)]-
• Paeoniflorm
• (1aR,2S,3aR,5R,5aR,5bS)-5b-[(Benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl β-D-glucopyranoside
• [(3S,3aR,6S,7aR)-3-(beta-D-glucopyranosyloxy)-7a-hydroxy-6-methyloctahydro-2,6-epoxy-1-benzofuran-3-yl]methyl benzoate
• Reishi Mushroom
• [(1aR,2R,3aR,5S,5aR,5bS)-1a-(beta-D-glucopyranosyloxy)-5-hydroxy-2-methyltetrahydro-1H-2,5-methano-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl benzoate
• [1a-(hexopyranosyloxy)-5-hydroxy-2-methyltetrahydro-1H-2,5-methano-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl benzoate
• [(1aR,2S,3aR,5R,5aR)-1a-(beta-D-glucopyranosyloxy)-5-hydroxy-2-methyltetrahydro-1H-2,5-methano-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl benzoate
• 2,5-Methano-1H-3,4-dioxacyclobuta[cd]pentalene, β-D-glucopyranoside deriv.
• Reishi Mushroom Extract
• [(1aR,2S,3aR,5R,5aR,5bS)-1a-(beta-D-glucopyranosyloxy)-5-hydroxy-2-methyltetrahydro-1H-2,5-methano-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl benzoate

Paeoniflorin

CAS: 23180-57-6

Formula: C₂₃H₂₈O₁₁

Purezza: >95.0%(NMR)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 480.47

Ref: 3B-P1876

PAEONIFLORIN CRS

CAS: 23180-57-6

PAEONIFLORIN CRS

Formula: C₂₃H₂₈O₁₁

Peso molecolare: 480.4618

Ref: 41-Y0001856

Paeoniflorin

CAS: 23180-57-6

Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives

Formula: C₂₃H₂₈O₁₁

Colore e forma: Off-White White Powder

Peso molecolare: 480.47

Ref: 45-1491616

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin

Purezza: ≥95%

Peso molecolare: 480.46g/mol

Ref: 54-BUP15107

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin

Purezza: 98%

Peso molecolare: 480.46g/mol

Ref: 54-OR1027748

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin, a novel heat shock protein-inducing compound, is mediated by the activation of heat shock transcription factor 1 (HSF1), which has antiallergic, anti-obesity, anti-inflammatory and immunoregulatory effects. Paeoniflorin can activate PI3K/Akt signaling pathway to protect the PC12 cell injury induced by Aβ25-35, it protects thymocytes against irradiation-induced cell damage by scavenging ROS and attenuating the activation of the mitogen-activated protein kinases.

Formula: C₂₃H₂₈O₁₁

Purezza: 95%~99%

Peso molecolare: 480.466

Ref: BP-BP1056

Paeoniflorin

CAS: 23180-57-6

Formula: C₂₃H₂₈O₁₁

Peso molecolare: 480.47

Ref: 4Z-P-311001

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.

Formula: C₂₃H₂₈O₁₁

Purezza: 96.9% - 97.43%

Colore e forma: White Fine Powder

Peso molecolare: 480.46

Ref: TM-T2230

Paeoniflorin

CAS: 23180-57-6

Formula: C₂₃H₂₈O₁₁

Purezza: ≥ 97.5%

Colore e forma: White powder

Peso molecolare: 480.46

Ref: 7W-GC2063

Paeoniflorin RS

CAS: 23180-57-6

Colore e forma: White Solid Powder

Ref: 2K-1144000021

Paeoniflorin

CAS: 23180-57-6

Natural glycoside

Formula: C₂₃H₂₈O₁₁

Purezza: ≥ 90.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 480.47

Ref: 5G-89384

Paeoniflorin (>80%)

Prodotto controllato

CAS: 23180-57-6

Applications Paeoniflorin is an active compound of the Paeonia root. Paeoniflorin inhibits Aβ25-35-induced mitochondrial dysfunction, which includes decreased mitochondrial membrane potential, increased Bax/Bcl-2 ratio, cytochrome c release and activity of caspase-3 and caspase-9. Paeoniflorin could attenuate or restore the viability loss, apoptotic increase, and ROS production induced by Aβ25-35 in SH-SY5Y cells.
References Yuan,Y., et. al.: Int. J. Mol. Sci., 14, 18502 (2013); Wang, K., et. al.: Cell Mol. Neurobiol., 34, 227 (2014)

Formula: C₂₃H₂₈O₁₁

Purezza: >80%

Colore e forma: Neat

Peso molecolare: 480.46

Ref: TR-P133830

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin is a bioactive compound, which is a monoterpene glycoside derived from the roots of Paeonia lactiflora, commonly known as peony. This compound functions through multiple mechanisms, including the modulation of calcium channels, the inhibition of the production of pro-inflammatory cytokines, and the regulation of neurotransmitter levels. It effectively exhibits anti-inflammatory and immunomodulatory effects.

Formula: C₂₃H₂₈O₁₁

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 480.46 g/mol

Ref: 3D-MP08290

PAEONIFLORIN

CAS: 23180-57-6

Purezza: 95%

Peso molecolare: 480.4660034

Ref: 10-F859163

b-D-Glucopyranoside,(1aR,2S,3aR,5R,5aR,5bS)-5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl

CAS: 23180-57-6

Formula: C₂₃H₂₈O₁₁

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 480.4618

Ref: IN-DA00I4J3

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin

Formula: C₂₃H₂₈O₁₁

Purezza: 88.6%

Colore e forma: Off-White

Peso molecolare: 480.16316

Ref: 47-769