CAS 23327-57-3

(±)-Cloridrato di nefopam

Descrizione:

(±)-Cloridrato di nefopam è un composto sintetico principalmente riconosciuto per le sue proprietà analgesiche. È classificato come analgesico non oppioide ed è spesso utilizzato per gestire il dolore, in particolare nei casi in cui gli oppioidi tradizionali potrebbero non essere adatti. La sostanza presenta un meccanismo d'azione unico, principalmente attraverso l'inibizione della ricaptazione di neurotrasmettitori come serotonina, norepinefrina e dopamina, che contribuisce ai suoi effetti antidolorifici. Chimicamente, è una miscela racemica, il che significa che contiene parti uguali di due enantiomeri, che possono mostrare diverse attività farmacologiche. Il cloridrato di nefopam viene tipicamente somministrato nella sua forma di sale cloridrato, migliorando la sua solubilità e stabilità. Il composto è noto per la sua relativamente bassa incidenza di effetti collaterali rispetto agli oppioidi, rendendolo un'alternativa preziosa nella gestione del dolore. Tuttavia, può comunque causare alcuni effetti avversi, tra cui nausea e vertigini. Come per qualsiasi farmaco, il suo utilizzo dovrebbe essere guidato da un professionista sanitario, considerando le esigenze individuali del paziente e le potenziali interazioni con altri farmaci.

Formula: C₁₇H₁₉NO·ClH

InChI: InChI=1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H

InChI key: InChIKey=CNNVSINJDJNHQK-UHFFFAOYSA-N

SMILES: CN1CC=2C(C(OCC1)C3=CC=CC=C3)=CC=CC2.Cl

Sinonimi:

• 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride
• 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride (1:1)
• 3,4,5,6-Tetrahydro-5-Methyl-1-Phenyl-1H-2,5-Benzoxazocine Hydrochloride
• 3-Methyl-7-Phenyl-6-Oxa-3-Azabicyclo[6.4.0]Dodeca-8,10,12-Triene Hydrochloride
• 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocin-5-ium chloride
• Acupan
• Fenazoxine
• Fenazoxine hydrochloride
• Nefopam HCl
• R 738
• Nefopam hydrochloride

Nefopam Hydrochloride

CAS: 23327-57-3

Formula: C₁₇H₁₉NO·HCl

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 289.80

Ref: 3B-N1169

5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine hydrochloride

CAS: 23327-57-3

Purezza: 95.0%

Colore e forma: Solid

Peso molecolare: 289.79998779296875

Ref: 10-F241971

Nefopam Hydrochloride

CAS: 23327-57-3

Colore e forma: Neat

Ref: 61-FOR1189.00

Nefopam Hydrochloride 1.0 mg/ml in Methanol (as free base)

CAS: 23327-57-3

Colore e forma: Single Solution

Ref: 61-AMP1189.00-01

(±)-Nefopam (hydrochloride)

CAS: 23327-57-3

Formula: C₁₇H₂₀ClNO

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 289.7998

Ref: IN-DA002MVZ

Nefopam hydrochloride

CAS: 23327-57-3

Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.

Formula: C₁₇H₂₀ClNO

Purezza: 99.32% - 99.85%

Colore e forma: Solid

Peso molecolare: 289.8

Ref: TM-T0470

Nefopam hydrochloride

CAS: 23327-57-3

Nefopam hydrochloride

Purezza: ≥98%

Peso molecolare: 289.8g/mol

Ref: 54-BUP18744

Nefopam hydrochloride

CAS: 23327-57-3

Formula: C₁₇H₁₉NO·HCl

Purezza: ≥ 98.0%

Colore e forma: White to off-white or beige powder

Peso molecolare: 289.80

Ref: 7W-GP9613

Nefopam HCl

CAS: 23327-57-3

Formula: C₁₇H₁₉NO·HCl

Colore e forma: White To Off-White Solid

Peso molecolare: 253.35 36.46

Ref: 4Z-N-371

Nefopam Hydrochloride

CAS: 23327-57-3

Nefopam Hydrochloride

Purezza: 98%

Peso molecolare: 289.8g/mol

Ref: 54-OR1029203

Nefopam-d4 HCl

CAS: 23327-57-3

Formula: C₁₇H₁₅D₄NO·HCl

Colore e forma: White To Off-White Solid

Peso molecolare: 257.37 36.46

Ref: 4Z-N-376

Nefopam Hydrochloride

Prodotto controllato

CAS: 23327-57-3

Formula: C₁₇H₁₉NO·ClH

Colore e forma: Neat

Peso molecolare: 289.80

Ref: 86-MM1189.00

Nefopam Hydrochloride

Prodotto controllato

CAS: 23327-57-3

Applications A cyclized analog of orphenadrine and diphenhydramine; representative of a new class of centrally acting skeletal muscle relaxants, the benzoxazocines. Analgesic; antidepressant.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bassett, et al.: Br. J. Pharmacol., 37, 69 (1969), Klohs, et al.: Arzneim.-Forsch., 22, 132 (1972), Hell, et al.: Drugs, 19, 249 (1980),

Formula: C₁₇H₁₉NO·ClH

Colore e forma: White To Off-White

Peso molecolare: 289.80

Ref: TR-N389400

Nefopam HCl - Bio-X ™

CAS: 23327-57-3

Nefopam is a non-narcotic analgesic drug that has been used in the treatment of chronic pain. It belongs to the class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). Nefopam is also a nasal drug that relieves pain by blocking neurokinin 1 receptor, which reduces the production of prostaglandins. Nefopam acts in the brain and spinal cord to relieve pain through different mechanisms such as antinociceptive effects from triple monoamine reuptake inhibition, and antihyperalgesic activity through modulation of glutamatergic transmission.

Formula: C₁₇H₁₉NO·HCl

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 289.8 g/mol

Ref: 3D-FN65100

Nefopam hydrochloride

CAS: 23327-57-3

3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine hydrochloride (THPP) is a drug that is used as an analgesic and anti-inflammatory agent. THPP interacts with nonsteroidal anti-inflammatory drugs (NSAIDs) to cause neuronal death. It has been shown to inhibit the plate test for prostaglandin synthesis in human erythrocytes. The disulfide bond between cysteine residues on the protein molecule is susceptible to oxidative cleavage by reactive oxygen species from reactive oxygen species such as hydrogen peroxide and lipid peroxidation products. This can lead to the formation of a thiolate ion and a sulfenic acid intermediate. THPP is also known to produce chronic oral toxicity in rats at doses of 837 mg/kg/day for two months. A chemiluminescence method was used to measure the reaction

Formula: C₁₇H₂₀ClNO

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 289.8 g/mol

Ref: 3D-FN26174

N-Hydroxymethyl Nefopam N-Oxide

CAS: 23327-57-3

Formula: C₁₇H₁₉NO₃

Colore e forma: White To Off-White Solid

Peso molecolare: 285.35

Ref: 4Z-N-3710