CAS 23541-50-6

Cloridrato di daunorubicina

Descrizione:

Cloridrato di daunorubicina è un antibiotico antraciclino derivato dal batterio Streptomyces peucetius, utilizzato principalmente nella terapia oncologica, in particolare per il trattamento della leucemia mieloide acuta e della leucemia linfoblastica acuta. Presenta un colore rosso-arancio ed è noto per le sue potenti proprietà citotossiche, che interferiscono con la replicazione e la trascrizione del DNA intercalandosi nei filamenti di DNA e inibendo la topoisomerasi II. Questo meccanismo porta all'apoptosi nelle cellule tumorali a rapida divisione. Cloridrato di daunorubicina viene tipicamente somministrato per via endovenosa e ha un profilo di effetti collaterali ben documentato, tra cui cardiotossicità, mielosoppressione e potenziale per malignità secondarie. La sua solubilità in acqua è migliorata dalla forma di sale cloridrato, rendendolo adatto per l'uso clinico. La farmacocinetica del composto coinvolge il metabolismo epatico e l'escrezione renale, ed è spesso utilizzato in combinazione con altri agenti chemioterapici per migliorare l'efficacia terapeutica. A causa dei suoi significativi benefici terapeutici e dei rischi associati, è essenziale un attento monitoraggio durante il trattamento.

Formula: C₂₇H₂₉NO₁₀·ClH

InChI: InChI=1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1

InChI key: InChIKey=GUGHGUXZJWAIAS-QQYBVWGSSA-N

SMILES: OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(C)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5.Cl

Sinonimi:

• (1R,3R)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-D-lyxo-hexopyranoside hydrochloride
• (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside hydrochloride
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride (1:1), (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S-cis)-
• Cerubidine
• Daunoblastin
• Daunomycin chlorohydrate
• Daunorubicin hydrochloride
• Daunorubicin, HCl
• Ndc 0082-4155
• Ondena
• RP 13057 hydrochloride
• Rubidomycin Hydrochloride
• Daunomycin, hydrochloride
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S-cis)-
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride (1:1), (8S,10S)-

Daunorubicin Hydrochloride

CAS: 20830-81-3, 23541-50-6

Formula: C₂₇H₂₉NO₁₀·HCl

Purezza: >98.0%(N)

Colore e forma: Orange to Red powder to crystal

Peso molecolare: 563.98

Ref: 3B-D4532

Daunorubicin hydrochloride

CAS: 23541-50-6

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₂₇H₃₀ClNO₁₀

Colore e forma: Powder, Orange to red

Peso molecolare: 563.98

Ref: 02-J60224

DAUNORUBICIN HYDROCHLORIDE CRS

CAS: 23541-50-6

DAUNORUBICIN HYDROCHLORIDE CRS

Formula: C₂₇H₃₀ClNO₁₀

Colore e forma: Powder

Peso molecolare: 563.9808

Ref: 41-D0125000

Daunorubicin Hydrochloride

CAS: 23541-50-6

Antibiotics nesoi

Formula: C₂₇H₂₉NO₁₀·HCI

Colore e forma: Red Orange Needles Crystalline Powder

Peso molecolare: 667.09144

Ref: 45-1164700

Daunorubicin hydrochloride

CAS: 23541-50-6

Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein

Formula: C₂₇H₂₉NO₁₀·HCl

Purezza: 96.21% - 99.53%

Colore e forma: Cancer Drug

Peso molecolare: 563.99

Ref: TM-T1511

(8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride

CAS: 23541-50-6

Formula: C₂₇H₃₀ClNO₁₀

Purezza: 90%

Colore e forma: Solid

Peso molecolare: 563.9808

Ref: IN-DA0037I5

Daunorubicin HCl (Epirubicin EP Impurity D HCl)

CAS: 23541-50-6

Formula: C₂₇H₂₉NO₁₀·HCl

Colore e forma: Orange Red Solid

Peso molecolare: 527.53 36.46

Ref: 4Z-D-481

Daunorubicin hydrochloride, EP grade

CAS: 23541-50-6

Formula: C₂₇H₂₉NO₁₀·HCl

Purezza: ≥ 90.0% (anhydrous)

Colore e forma: Orange-red crystalline powder

Peso molecolare: 563.98

Ref: 7W-GA7448

Daunorubicin hydrochloride

CAS: 23541-50-6

Daunorubicin hydrochloride

Purezza: ≥95%

Peso molecolare: 563.99g/mol

Ref: 54-BUP15460

Daunorubicin hydrochloride

CAS: 23541-50-6

Daunorubicin hydrochloride

Purezza: 98%

Peso molecolare: 563.9808g/mol

Ref: 54-BID0122

Daunorubicin hydrochloride

Prodotto controllato

CAS: 23541-50-6

Formula: C₂₇H₂₉NO₁₀·ClH

Colore e forma: Neat

Peso molecolare: 563.98

Ref: 04-C11968000

Daunorubicin Hydrochloride

Prodotto controllato

CAS: 23541-50-6

Formula: C₂₇H₂₉NO₁₀·ClH

Colore e forma: Neat

Peso molecolare: 563.98

Ref: 86-MM0284.00

Daunorubicin Hydrochloride

CAS: 23541-50-6

Applications Anthracycline antibiotic related to the rhodomycins. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yang, Z., et al.: J. Pharmacol. Experim. Ther., 327, 474 (2008), Zhao, Y., et al.: Int. J. Pharm., 379, 90 (2009), Bayne, W., et al.: J. Pharm. Sci., 98, 2540 (2009),

Formula: C₂₇H₂₉NO₁₀·ClH

Colore e forma: Red

Peso molecolare: 563.98

Ref: TR-D194500

Daunorubicin HCl - Bio-X ™

CAS: 23541-50-6

Daunorubicin is an anthracycline antibiotic and antineoplastic agent that is used in the treatment of a variety of cancers such as nonlymphocytic leukemia and acute lymphocytic leukemia. The drug binds to DNA and inhibits transcription by intercalating between DNA base pairs and affecting the activity of the topoisomerase II enzyme and thus the gene expression. This results in apoptosis, mitochondrial injury, and finally cell death.

Formula: C₂₇H₂₉NO₁₀•HCl

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 563.98 g/mol

Ref: 3D-BD164356

Daunorubicin HCl

CAS: 23541-50-6

Anthracycline antibiotic with potent anti-tumoral activity. The compound interferes with DNA replication and RNA transcription since it intercalates between the base pairs of nucleic acids. It also inhibits the topoisomerase II, proteasome and generates free radicals, which leads to cell death of treated cells. Moreover, daunorubicin triggers apoptosis trough the stimulation of ceramide synthesis. It has been used as chemotherapy agent for the treatment of myeloid leukaemia (AML) and acute lymphocytic leukaemia (ALL).

Formula: C₂₇H₂₉NO₁₀·HCl

Purezza: Min. 95%

Colore e forma: Red Powder

Peso molecolare: 563.98 g/mol

Ref: 3D-MD11679

Doxorubicin EP Impurity A

CAS: 23541-50-6

Formula: C₂₇H₂₉NO₁₀HCl

Peso molecolare: 527.5 : 36.46

Ref: ST-EA-CP-D102001

Epirubicin EP Impurity D

CAS: 23541-50-6

Formula: C₂₇H₂₉NO₁₀HCl

Peso molecolare: 527.53 : 36.46

Ref: ST-EA-CP-E117004