CAS 23583-48-4

8-Bromo-cAMP

Descrizione:

8-Bromo-cAMP, con il numero CAS 23583-48-4, è un derivato sintetico dell'adenosina monofosfato ciclico (cAMP), un secondo messaggero cruciale in vari processi biologici. Questo composto è caratterizzato dalla presenza di un atomo di bromo nella posizione 8 dell'anello di adenina, che ne migliora la stabilità e altera la sua attività biologica rispetto al cAMP naturale. 8-Bromo-cAMP è spesso utilizzato nella ricerca biochimica per studiare le vie di trasduzione del segnale, in particolare quelle che coinvolgono la proteina chinasi A (PKA), poiché può imitare gli effetti del cAMP pur essendo resistente alla degradazione da parte delle fosfodiesterasi. Il composto è tipicamente solubile in acqua e solventi organici, rendendolo versatile per applicazioni di laboratorio. La sua capacità di attivare la PKA e influenzare le risposte cellulari lo rende uno strumento prezioso in farmacologia e biologia cellulare. Tuttavia, come molte sostanze chimiche, deve essere maneggiato con cura, seguendo i protocolli di sicurezza appropriati a causa dei suoi potenziali effetti biologici.

Formula: C₁₀H₁₁BrN₅O₆P

InChI: InChI=1/C10H11BrN5O6P/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14)/t3-,5-,6-,9-/m1/s1

InChI key: InChIKey=DVKQVRZMKBDMDH-UUOKFMHZSA-N

SMILES: BrC=1N(C=2C(N1)=C(N)N=CN2)[C@H]3[C@H](O)[C@]4([C@](O3)(COP(=O)(O)O4)[H])[H]

Sinonimi:

• (4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide
• 23583-48-4
• 3',5'-(Hidrogenofosfato) Ciclico De 8-Bromoadenosina
• 3',5'-(Hydrogenophosphate) Cyclique De 8-Bromoadenosine
• 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, adenosine deriv.
• 6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide
• 8-Bromadenosin-cyclisch-3',5'-(hydrogenphosphat)
• 8-Bromo-cAMP
• 8-Bromo-cyclic 3',5'-AMP
• 8-Bromo-cyclic 3′,5′-AMP
• 8-Bromoadenosine Cyclic 3',5'-(Hydrogen Phosphate)
• 8-Bromoadenosine cyclic 3',5'-monophosphate
• 8-Bromoadenosine cyclic 3',5'-phosphate
• 8-Bromoadenosine cyclic 3′,5′-monophosphate
• 8-Bromoadenosine cyclic 3′,5′-phosphate
• 8-Bromoadenosine-cAMP
• Adenosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate)
• Adenosine, 8-bromo-, cyclic 3′,5′-(hydrogen phosphate)
• Cyclic 8-bromoadenosine 3',5'-monophosphate
• Cyclic 8-bromoadenosine 3′,5′-monophosphate
• Nsc 171719
• 8-Bromo Cyclic Adenosine Monophosphate
• 8-BROMOADENOSINE-3-5-CYCLICMONOPHOSPHATE FREE ACID
• 8-Bromoadenosine 3',5'-monophosphate
• 8-Br-A-3:5-MP
• 8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE USP/EP/BP
• -CyclicMonophosphate
• 8-BR-CAMP
• 8-BROMOADENOSINE 3' 5'-CYCLIC
• 8-bromo-3',5'-cyclic AMP
• 8-BR-CAMP,98+%
• B-cAMP
• 8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE
• 8-Bromoadenosine 3',5'-phosphoric acid
• 8-Bromoadenosine-3'',-5''-cyclic monophosphoric acid
• 8-BROMOADENOSINE-3',5'-CYCLOPHOSPHATE
• 8-Bromocyclic AMP
• 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE
• Cyclic amp, 8-bromo
• 8-BROMOADENOSINE-3',5'-CYCLOPHOSPHORIC ACID

8-Bromoadenosine-3',5'-cyclic monophosphate

CAS: 23583-48-4

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Formula: C₁₀H₁₁BrN₅O₆P

Peso molecolare: 408.11

Ref: 02-J64469

8-Bromoadenosine cyclic 3',5'-monophosphate

CAS: 23583-48-4

Formula: C₁₀H₁₁BrN₅O₆P

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 408.1020

Ref: IN-DA002NRS

8-Bromoadenosine 3'',5''-cyclic monophosphate

CAS: 23583-48-4

Formula: C₁₀H₁₁BrN₅O₆P

Peso molecolare: 408.11

Ref: 7W-GN1084

8-Bromo-cAMP

CAS: 23583-48-4

8-Bromo-cAMP

Purezza: ≥95%

Peso molecolare: 408.1g/mol

Ref: 54-OR1005158

8-Bromo-cAMP

CAS: 23583-48-4

8-Bromo-cAMP is a cell-permeable cAMP analogue and activator of CAMP-dependent protein kinase A that induces cell death and reduces proliferation.

Formula: C₁₀H₁₁BrN₅O₆P

Purezza: 97.30%

Colore e forma: Solid

Peso molecolare: 408.1

Ref: TM-T35424

8-Bromoadenosine 3',5'-cyclic monophosphate

CAS: 23583-48-4

8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) is a cyclic nucleotide that is involved in the regulation of energy metabolism. It is a pharmacological agent that regulates the intracellular levels of cAMP and plays an important role in regulating cell proliferation, differentiation, and survival. 8-Br-cAMP binds to specific protein kinases and alters their activity. It also inhibits the enzymatic activity of DNA polymerase II. 8-Br-cAMP has been shown to inhibit tumor growth in mice with bone cancer. The mechanism by which this drug exerts its antitumor effect appears to be related to increased expression of basic proteins and decreased expression of phosphatase 2A, leading to increased activation of protein kinase A. 8-Br-cAMP also causes cellular accumulation of Ca2+ ions by stimulating an increase in the activity of phospholipase C, which hydrolyzes phosphat

Formula: C₁₀H₁₁BrN₅O₆P

Purezza: Min. 98 Area-%

Colore e forma: Beige Powder

Peso molecolare: 408.11 g/mol

Ref: 3D-NB07972

8-Bromo-cAMP

CAS: 23583-48-4

Purezza: 98%

Peso molecolare: 406.96

Ref: 10-F554595