CAS 2361241-23-6

BI-749327

CAS: 2361241-23-6

BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).

Formula: C₂₃H₂₁F₃N₄O₂

Purezza: 99.68% - 99.84%

Colore e forma: Solid

Peso molecolare: 442.43

Ref: TM-T10537

BI-749327

CAS: 2361241-23-6

BI-749327

Purezza: ≥98%

Peso molecolare: 442.43g/mol

Ref: 54-BUP06968

(4-(6-Aminopyridazin-3-yl)piperidin-1-yl)(4-(4-(trifluoromethyl)phenoxy)phenyl)methanone

CAS: 2361241-23-6

(4-(6-Aminopyridazin-3-yl)piperidin-1-yl)(4-(4-(trifluoromethyl)phenoxy)phenyl)methanone is a small molecule that interacts with the transient receptor potential cation channel subfamily V member 1 (TRPV1). This receptor is activated by heat and capsaicin, making it an important target for pain management. TRPV1 activation leads to the opening of the ion channel and the influx of sodium ions, leading to depolarization and pain sensation. The TRPV1 receptor is also involved in gastrointestinal motility and inflammation, as well as other processes. The piperidine group in this compound binds to the TRPV1 ligand binding domain, while the phenoxy group binds to a hydrophobic pocket on the protein surface. This binding leads to increased activity of TRPV1 channels, which can be measured using single

Formula: C₂₃H₂₁F₃N₄O₂

Purezza: Min. 95%

Peso molecolare: 442.4 g/mol

Ref: 3D-LUD24123