CAS 2410-93-7

Metopterina

Descrizione:

Metopterina, noto anche come 4-amino-4-deossì-N10-metilpteroilglutammico, è un analogo del folato e un membro della classe dei composti antifolato. È principalmente riconosciuto per il suo ruolo di inibitore della diidrofolato reduttasi, un enzima critica nella sintesi degli acidi nucleici. Metopterina è caratterizzato dalla sua struttura complessa, che include un anello di pteridina, un gruppo di acido para-amminobenzoico e una catena laterale di acido glutammico. Questo composto è spesso utilizzato nel trattamento di alcuni tumori e malattie autoimmuni grazie alla sua capacità di interferire con la proliferazione cellulare. Metopterina è solubile in acqua e presenta un peso molecolare relativamente basso. I suoi effetti farmacologici sono attribuiti alla sua capacità di imitare il folato naturale, interrompendo così il metabolismo del folato nelle cellule in rapida divisione. Sebbene abbia applicazioni terapeutiche, Metopterina può anche portare a effetti collaterali, richiedendo un attento monitoraggio durante il trattamento. In generale, Metopterina serve come uno strumento importante nella chimica medica, in particolare in oncologia e immunologia.

Formula: C₂₀H₂₁N₇O₆

InChI: InChI=1/C20H21N7O6/c1-27(9-11-8-22-16-15(23-11)18(31)26-20(21)25-16)12-4-2-10(3-5-12)17(30)24-13(19(32)33)6-7-14(28)29/h2-5,8,13H,6-7,9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H3,21,22,25,26,31)

InChI key: InChIKey=HLIXOCXUWGDBNP-ZDUSSCGKSA-N

SMILES: O=C1C=2C(NC=C(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)N2)=NC(N)=N1

Sinonimi:

• 10-Methylfolic acid
• 10-Methylpteroylglutamic acid
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
• Glutamic acid, N-[p-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-, <span class="text-smallcaps">L</span>-
• Glutamic acid, N-[p-[[(2-amino-4-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]-
• Methopterin
• Methopterine
• N-(4-{[(2-amino-4-hydroxypteridin-6-yl)methyl](methyl)amino}benzoyl)glutamic acid
• N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[4-[[(2-Amino-4-hydroxy-6-pteridinyl)-methyl]methylamino]benzoyl]glutamic Acid
• N¹⁰-Methylfolic acid
• N¹⁰-Methylpteroylglutamic acid
• NSC 107144
• glutamic acid, N-[4-[[(2-amino-4-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]-
• L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
• L-Glutamic acid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
• Glutamic acid, N-[p-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-, L-
• N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
• N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid
• N-(4-{[(2-Amino-4-hydroxypteridin-6-yl)methyl](methyl)amino}benzoyl)-L-glutamic acid
• 2410-93-7
• Methotrexate Related Compound C (50 mg) ((S)-2-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](methyl)amino}benzamido) pentanedioic acid)
• N10-MethylpteroylglutaMic Acid
• N10-Methylfolic acid
• Methotrexate-EP-Imp-C
• (2S)-2-[[4-[[(2-amino-4-hydroxy pteridin-6-yl) methyl] methyl amino] benzoyl] amino] pentanedioic acid
• N(10)-methylfolate
• Methotrexate Impurity 3(EP-C)
• benzoyl]glutaMic Acid
• N-[4-[Methyl(2-amino-4-hydroxypteridine-6-ylmethyl)amino]benzoyl]glutamic acid
• L-Glutamic acid, N-[4-[[ (2-amino-1, 4-dihydro-4-oxo-6-pteridinyl)meth yl]methylamino]benzoyl]-
• Methotrexate imp C (Mono oxo imp)
• Methotrexate EP IMpurity C
• N-[p-[[(2-Amino-4-hydroxypteridin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid
• Methotrexate EP Impurity C（Amethopterin EP Impurity C）
• N-[p-[[(2-AMino-4-hydroxy-6-pteridinyl)Methyl]MethylaMino]
• N-[p-[[(2-AMino-3,4-dihydro-4-oxo-6-pteridinyl)Methyl]MethylaMino]benzoyl]- L-glutaMic Acid
• Methotrexate Impurity 3（Methotrexate EP Impurity C）
• Methotrexate Related CoMpound C
• N-[4-[[(2-AMino-1,4-dihydro-4-oxo-6-pteridinyl)
• 2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid
• Methyl]MethylaMino]benzoyl]-L-glutaMic Acid
• 2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxylic Acid
• N-[4-[[(2-Amino-4-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid

METHOTREXATE IMPURITY C CRS

CAS: 2410-93-7

METHOTREXATE IMPURITY C CRS

Ref: 41-Y0000663

Methotrexate Related Compound C ((S)-2-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](methyl)amino}benzamido) pentanedioic acid)

CAS: 2410-93-7

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Formula: C₂₀H₂₁N₇O₆

Colore e forma: Dark Yellow Orange Powder

Peso molecolare: 455.15533

Ref: 45-1414036

(S)-2-(4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid

CAS: 2410-93-7

(S)-2-(4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid

Purezza: 98%

Peso molecolare: 455.43g/mol

Ref: 54-OR1074673

Methopterin

CAS: 2410-93-7

Methopterin shows the activation and bone resorption function of murine osteoclasts.

Formula: C₂₀H₂₁N₇O₆

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 455.43

Ref: TM-T20338

(2S)-2-[[4-[[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]methylamino]benzoyl]amino]pentanedioic Acid (N-Methylfolic Acid, Methopterin)

Prodotto controllato

CAS: 2410-93-7

Formula: C₂₀H₂₁N₇O₆

Colore e forma: Neat

Peso molecolare: 455.42

Ref: 86-MM0040.06

Methotrexate EP Impurity C (Methotrexate USP Related Compound C)

CAS: 2410-93-7

Formula: C₂₀H₂₁N₇O₆

Peso molecolare: 455.43

Ref: 4Z-M-704

Methotrexate EP Impurity C

CAS: 2410-93-7

Formula: C₂₀H₂₁N₇O₆

Peso molecolare: 455.43

Ref: ST-EA-CP-M12041

Methopterine (>90%)

Prodotto controllato

CAS: 2410-93-7

Impurity Methotrexate EP Impurity C; Methotrexate USP Related Compound C
Applications Methopterine (Methotrexate EP Impurity C) is a Folic acid (F680300) analogue. Methopterine is effective in the treatment of ectopic pregnancy. Methotrexate USP Related Compound C
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References McNamara, P., et al.: Drug Metab. Dispos., 20, 302 (1992), Soldin, O., et al.: Ther. Drug Monit., 24, 1 (2002), Nicoli, S., et al.: J. Pharm. Biomed. Anal., 41, 994 (2006),

Formula: C₂₀H₂₁N₇O₆

Purezza: >90%

Colore e forma: Neat

Peso molecolare: 455.42

Ref: TR-M305370

Methopterine-d3

Prodotto controllato

CAS: 2410-93-7

Applications Labelled Methopterine (M305370). Methopterine is a Folic acid (F680300) analogue. Methopterine is effective in the treatment of ectopic pregnancy.
References McNamara, P., et al.: Drug Metab. Dispos., 20, 302 (1992), Soldin, O., et al.: Ther. Drug Monit., 24, 1 (2002), Nicoli, S., et al.: J. Pharm. Biomed. Anal., 41, 994 (2006),

Formula: C₂₀H₁₈D₃N₇O₆

Colore e forma: Neat

Peso molecolare: 458.44

Ref: TR-M305372

Methotrexate Related Compound C

CAS: 2410-93-7

Methotrexate Related Compound C (MRCC) is a drug that binds to the folate receptor and inhibits the synthesis of purines, pyrimidines, and dNTPs. It can be used in the treatment of autoimmune diseases, cancer, and hyperproliferative diseases. MRCC is not effective against acute lymphoblastic leukemia or myelodysplastic syndrome. MRCC has been shown to have therapeutic effects on skin cancer cells in tissue culture by inhibiting their proliferation. The mechanism of action may be due to its ability to inhibit protein kinase C activity. MRCC has been shown to be an effective inhibitor of lipid kinase in vitro and in vivo.

Formula: C₂₀H₂₁N₇O₆

Purezza: Min. 95%

Peso molecolare: 455.42 g/mol

Ref: 3D-CAA41093