CAS 2451398-65-3

TAS2940 free base

CAS: 2451398-65-3

TAS2940 is an irreversible pan-ERBB inhibitor with enhanced brain penetration, utilized for treating lung cancer brain metastases and glioblastomas with HER2/EGFR exon 20 insertions and EGFR abnormalities. In intracranial xenograft models of HER2/EGFR cancers, TAS2940 has demonstrated efficacy in improving survival rates in mice. Currently, TAS2940 is undergoing Phase I clinical trials to establish the maximum tolerated dose for solid tumors.

Formula: C₂₈H₃₀N₆O₂

Peso molecolare: 482.58

Ref: TM-T202527