CAS 2457-80-9

5′-(Metiltio)adenosina

Descrizione:

5′-(Metiltio)adenosina, noto anche come MTA, è un composto che si verifica naturalmente e svolge un ruolo significativo in vari processi biologici. È un derivato dell'adenosina, in cui un gruppo metiltio è attaccato alla posizione 5' dello zucchero ribosio. L'MTA è caratterizzato dal suo coinvolgimento nella segnalazione cellulare e nel metabolismo, in particolare nel contesto del metabolismo delle purine e come potenziale modulatore delle funzioni cellulari. Presenta proprietà come quella di essere un substrato per vari enzimi e avere implicazioni nella regolazione delle risposte immunitarie e dell'infiammazione. L'MTA è anche noto per il suo ruolo nella sintesi delle poliammine, essenziali per la crescita e la differenziazione cellulare. In termini di solubilità, è generalmente solubile in acqua e solventi polari, rendendolo accessibile per varie applicazioni biochimiche. Il suo numero CAS, 2457-80-9, è utilizzato per l'identificazione in banche dati chimiche e contesti normativi. In generale, 5′-(Metiltio)adenosina è un composto di interesse sia nella ricerca biochimica che nelle potenziali applicazioni terapeutiche.

Formula: C₁₁H₁₅N₅O₃S

InChI: InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1

InChI key: InChIKey=WUUGFSXJNOTRMR-IOSLPCCCSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CSC)[C@H]1O

Sinonimi:

• 5'-(Methylthio)adenosine
• 5'-Deoxy-5'-Methylthioadenosine
• 5'-Methylthioadenosine
• 5'-S-Methyl-5'-thioadenosine
• 5'-S-Methylthioadenosine
• 5′-(Methylthio)-5′-deoxyadenosine
• 5′-Deoxy(methylthio)adenosine
• 9-(5-S-methyl-5-thiopentofuranosyl)-9H-purin-6-amine
• Adenosine, 5'-S-methyl-5'-thio-
• Brn 0042420
• Methylthioadenosine
• Nsc 335422
• Vitamin L(sub 2)
• Vitamin L2
• Vitamin L₂
• β-<span class="text-smallcaps">D</span>-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-
• 4-26-00-03675 (Beilstein Handbook Reference)

Adenosine, 5'-S-methyl-5'-thio-

CAS: 2457-80-9

Formula: C₁₁H₁₅N₅O₃S

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 297.3335

Ref: IN-DA002OLP

5'-Methylthioadenosine

CAS: 2457-80-9

5'-Methylthioadenosine

Purezza: ≥98%

Peso molecolare: 297.33g/mol

Ref: 54-BUP14383

5’-Methylthioadenosine

CAS: 2457-80-9

5’-Methylthioadenosine

Purezza: 98%

Peso molecolare: 297.33g/mol

Ref: 54-OR1011792

5''-Deoxy-5''-(methylthio)adenosine

CAS: 2457-80-9

Formula: C₁₁H₁₅N₅O₃S

Peso molecolare: 297.33

Ref: 7W-GN7022

Adenosyl Methionine Impurity 1

CAS: 2457-80-9

Formula: C₁₁H₁₅N₅O₃S

Colore e forma: White To Off-White Solid

Peso molecolare: 297.33

Ref: 4Z-A-106029

5'-Deoxy-5'-methylthioadenosine

CAS: 2457-80-9

Formula: C₁₁H₁₅N₅O₃S

Purezza: >95.0%(T)(HPLC)

Colore e forma: White to Light yellow to Light orange powder to crystal

Peso molecolare: 297.33

Ref: 3B-M3801

5'-S-Methyl-5'-thioadenosine

CAS: 2457-80-9

Formula: C₁₁H₁₅N₅O₃S

Purezza: 95%~99%

Colore e forma: Powder

Peso molecolare: 297.333

Ref: BP-SBP01153

5'-Methylthioadenosine

CAS: 2457-80-9

5'-Methylthioadenosine (Methylthioadenosine) is produced from S-adenosylmethionine and behaves as a powful inhibitory product.

Formula: C₁₁H₁₅N₅O₃S

Purezza: 99.32% - 99.34%

Colore e forma: Solid

Peso molecolare: 297.33

Ref: TM-T8227

Adenosyl Methionine Impurity 1-13C5

CAS: 2457-80-9

Formula: C₆₁₃C₅H₁₅N₅O₃S

Peso molecolare: 302.29

Ref: 4Z-A-106046

5'-Deoxy-5'-(methylthio)adenosine-d3

Prodotto controllato

CAS: 2457-80-9

Applications Labelled 5'-Deoxy-5'-(methylthio)adenosine (D242600). 5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN).
References Pegg, A., et al.: Biochem. J., 115, 241 (1969), Olopade, O., et al.: Cancer Res., 53, 2410 (1993), Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),

Formula: C₁₁H₁₂D₃N₅O₃S

Colore e forma: Neat

Peso molecolare: 300.35

Ref: TR-D242602

5'-Deoxy-5'-(methylthio)adenosine-13C

Prodotto controllato

CAS: 2457-80-9

Applications A Labelled isotope of 5'-Deoxy-5'-(methylthio)adenosine (D242600) which is used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28)
References Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),

Formula: CC₁₀H₁₅N₅O₃S

Colore e forma: Neat

Peso molecolare: 298.326

Ref: TR-D242604

5'-Deoxy-5'-(methylthio)adenosine

CAS: 2457-80-9

Applications 5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN).
References Pegg, A., et al.: Biochem. J., 115, 241 (1969), Olopade, O., et al.: Cancer Res., 53, 2410 (1993), Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),

Formula: C₁₁H₁₅N₅O₃S

Colore e forma: White To Off-White

Peso molecolare: 297.33

Ref: TR-D242600

5'-Deoxy-5'-(methylthio)adenosine

CAS: 2457-80-9

5'-Deoxy-5'-(methylthio)adenosine is a nucleoside that has been shown to inhibit the growth of bowel cancer cells. 5'-Deoxy-5'-(methylthio)adenosine blocks the synthesis of DNA and RNA by inhibiting the action of enzymes involved in DNA metabolism. It also inhibits methionine synthase and phosphorylase, which are involved in protein synthesis. This compound has been shown to be effective in treating cancer tissues due to its ability to inhibit polymerase chain reactions and prevent the formation of cancerous cells.

Formula: C₁₁H₁₅N₅O₃S

Purezza: (Hplc-Ms) Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 297.34 g/mol

Ref: 3D-ND07992

(2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-3,4-diol

CAS: 2457-80-9

Formula: C₁₁H₁₅N₅O₃S

Purezza: 96%

Peso molecolare: 297.33

Ref: 10-F230436

5'-Deoxy-5'-(methylthio)adenosine-15N5

Prodotto controllato

CAS: 2457-80-9

Formula: C₁₁H₁₅₁₅N₅O₃S

Colore e forma: Neat

Peso molecolare: 302.3

Ref: TR-D242603

5’-Deoxy-5’-(methylthio)adenosine

Prodotto controllato

CAS: 2457-80-9

Formula: C₁₁H₁₅N₅O₃S

Colore e forma: Neat

Peso molecolare: 297.33

Ref: TR-D232740

5\'-Deoxy-5\'-(methylthio)adenosine

CAS: 2457-80-9

Formula: C₁₁H₁₅N₅O₃S

Peso molecolare: 297.33

Ref: ST-EA-CP-A88010