CAS 247257-48-3

Fimasartan

Descrizione:

Fimasartan è un antagonista del recettore dell'angiotensina II utilizzato principalmente nel trattamento dell'ipertensione. Appartiene alla classe di farmaci noti come sartani, che agiscono bloccando l'azione dell'angiotensina II, un ormone che provoca la costrizione dei vasi sanguigni, abbassando così la pressione sanguigna. Fimasartan è caratterizzato dalla sua inibizione selettiva del recettore AT1, che contribuisce ai suoi effetti antipertensivi. La sostanza è tipicamente somministrata per via orale e ha una emivita relativamente lunga, consentendo una somministrazione una volta al giorno. In termini di struttura chimica, Fimasartan presenta un quadro molecolare unico che include un gruppo bifenile e un gruppo acido carbossilico, contribuendo alle sue proprietà farmacologiche. È generalmente ben tollerato, con un profilo di effetti collaterali simile ad altri farmaci della sua classe, tra cui vertigini, affaticamento e potenziali effetti renali. Come con qualsiasi farmaco, è essenziale utilizzare Fimasartan sotto supervisione medica, considerando le possibili interazioni con altri farmaci e le condizioni di salute individuali del paziente.

Formula: C₂₇H₃₁N₇OS

InChI: InChI=1S/C27H31N7OS/c1-5-6-11-24-28-18(2)23(16-25(36)33(3)4)27(35)34(24)17-19-12-14-20(15-13-19)21-9-7-8-10-22(21)26-29-31-32-30-26/h7-10,12-15H,5-6,11,16-17H2,1-4H3,(H,29,30,31,32)

InChI key: InChIKey=AMEROGPZOLAFBN-UHFFFAOYSA-N

SMILES: C(C1=CC=C(C2=C(C=CC=C2)C=3NN=NN3)C=C1)N4C(CCCC)=NC(C)=C(CC(N(C)C)=S)C4=O

Sinonimi:

• 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-5-pyrimidineethanethioamide
• 2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one
• 2-[2-Butyl-4-methyl-6-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-5-yl]-N,N-dimethylethanethioamide
• 2-n-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one
• 5-Pyrimidineethanethioamide, 2-butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
• 5-Pyrimidineethanethioamide, 2-butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
• Kanarb
• Fimasartan
• 2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one USP/EP/BP
• 2-(2-butyl-4-Methyl-6-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methoxy)pyriMidin-5-yl)-N,N-diMethylacetaMide-yl)-N,N-diMethylacetaMide
• 2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrim
• BR-A-657
• 2-(2-butyl-4-Methyl-6-oxo-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-1,6-dihydropyriMidin-5-yl)-N,N-diMethylethanethioaMide
• 2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-N,N-dimethylethanethioamide
• KANARB; BR-A-657
• Fimasartan(BR-A-657)
• Unii-p58222188p
• 2-(2-butyl-4-methyl-6-((2'-(1-trityl-1H-tetrazol-5-yl)-[ 1,1'-biphenyl]-4-yl)methoxy)pyrimidin-5-yl)-N,N- dimethylacetamide
• FiMasartan USP/EP/BP

5-​Pyrimidineethanethio​amide, 2-​butyl-​1,​6-​dihydro-​N,​N,​4-​trimethyl-​6-​oxo-​1-​[[2'-​(2H-​tetrazol-​5-​yl)​[1,​1'-​biphenyl]​-​4-​yl]​methyl]​-

CAS: 247257-48-3

Formula: C₂₇H₃₁N₇OS

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 501.6463

Ref: IN-DA002P8I

Fimasartan

CAS: 247257-48-3

Fimasartan

Purezza: ≥95%

Peso molecolare: 501.65g/mol

Ref: 54-BUP06317

Fimasartan-d6

CAS: 247257-48-3

Formula: C₂₇H₂₅D₆N₇OS

Colore e forma: White To Off-White Solid

Peso molecolare: 507.69

Ref: 4Z-F-492

Fimasartan

CAS: 247257-48-3

Formula: C₂₇H₃₁N₇OS

Colore e forma: White To Off-White Solid

Peso molecolare: 501.65

Ref: 4Z-F-491

2-(1-((2'-(2H-Tetrazol-5-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-2-Butyl-4-Methyl-6-Oxo-1,6-Dihydropyrimidin-5-Yl)-N,N-Dimethylethanethioamide

CAS: 247257-48-3

2-(1-((2'-(2H-Tetrazol-5-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-2-Butyl-4-Methyl-6-Oxo-1,6-Dihydropyrimidin-5-Yl)-N,N-Dimethylethanethioamide

Purezza: 99%

Peso molecolare: 501.65g/mol

Ref: 54-OR1025664

Fimasartan

CAS: 247257-48-3

Fimasartan (BR-A-657), an ARB, treats hypertension and heart failure; safe with hydrochlorothiazide.

Formula: C₂₇H₃₁N₇OS

Purezza: 98.96%

Colore e forma: Solid

Peso molecolare: 501.65

Ref: TM-T2322

Fimasartan

CAS: 247257-48-3

Angiotensin II receptor antagonist

Formula: C₂₇H₃₁N₇OS

Purezza: Min. 95%

Colore e forma: White To Yellow Solid

Peso molecolare: 501.65 g/mol

Ref: 3D-FB75008

Fimasartan

Prodotto controllato

CAS: 247257-48-3

Applications Fimasartan is a new angiotensin II receptor blocker antagonist and also functions as an antihypertensive agent.
References Lee, H., et al.: Drugs, 76, 1015 (2016)

Formula: C₂₇H₃₁N₇OS

Colore e forma: Neat

Peso molecolare: 501.65

Ref: TR-F342040