CAS 24729-96-2

Fosfato di clindamicina

Descrizione:

Fosfato di clindamicina è un antibiotico semisintetico derivato dalla lincomicina, utilizzato principalmente per trattare varie infezioni batteriche, in particolare quelle causate da batteri anaerobi e alcuni organismi gram-positivi. È caratterizzato dalla sua forma di estere fosfato, che ne migliora la solubilità e stabilità in soluzioni acquose, rendendolo adatto per formulazioni parenterali e topiche. Fosfato di clindamicina mostra un meccanismo d'azione inibendo la sintesi proteica batterica attraverso il legame con la subunità ribosomiale 50S, interrompendo efficacemente la crescita dei batteri suscettibili. Il composto è spesso utilizzato nel trattamento di infezioni cutanee, infezioni delle vie respiratorie e alcuni tipi di infezioni ossee. È importante notare che Fosfato di clindamicina può causare effetti collaterali, inclusi disturbi gastrointestinali e il rischio di diarrea associata a Clostridium difficile. Come con qualsiasi antibiotico, un uso appropriato è cruciale per minimizzare lo sviluppo di resistenza. La sostanza è tipicamente somministrata in varie forme, tra cui gel, creme e soluzioni iniettabili, a seconda dell'indicazione clinica specifica.

Formula: C₁₈H₃₄ClN₂O₈PS

InChI: InChI=1S/C18H34ClN2O8PS/c1-5-6-10-7-11(21(3)8-10)17(24)20-12(9(2)19)15-13(22)14(23)16(18(28-15)31-4)29-30(25,26)27/h9-16,18,22-23H,5-8H2,1-4H3,(H,20,24)(H2,25,26,27)/t9-,10+,11-,12+,13+,14-,15+,16+,18+/m0/s1

InChI key: InChIKey=UFUVLHLTWXBHGZ-MGZQPHGTSA-N

SMILES: [C@@H](NC(=O)[C@@H]1C[C@@H](CCC)CN1C)([C@H](C)Cl)[C@]2(O[C@H](SC)[C@H](OP(=O)(O)O)[C@@H](O)[C@H]2O)[H]

Sinonimi:

• 7(S)-Chloro-7-deoxylincomycin 2-phosphate
• <span class="text-smallcaps">L</smallcap>-threo-<smallcap>D</smallcap>-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-<smallcap>L</span>-2-pyrrolidinecarboxamido)-1-thio-, 2-(dihydrogen phosphate), trans- α-
• <span class="text-smallcaps">L</smallcap>-threo-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, 2-(dihydrogen phosphate), (2S-trans)-
• <span class="text-smallcaps">L</smallcap>-threo-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, 2-(dihydrogen phosphate)
• Cleocin T
• Cleocin phosphate
• Clinadac
• Clindac
• Clindagel
• Clindamycin 2-phosphate
• Clindesse
• Clindets
• Dalacin P
• Dalacin T
• Methyl 7-Chloro-6,7,8-Trideoxy-6-(1-Methyl-Trans-4-Propyl-L-2-Pyrrolidinecarboxamido)-1-Thio-L-Threo-Alpha-D-Galacto-Octopyranoside 2-(Dihydrogen Phosphate)
• Methyl 7-chloro-6,7,8-trideoxy-6-trans-(1-methyl-4-propyl-<span class="text-smallcaps">L</smallcap>-2-pyrrolidinecarboxamido)-1-thio-<smallcap>L</smallcap>-threo-α-<smallcap>D</span>-galacto-octopyranoside 2-(dihydrogen phosphate)
• NSC 618653
• U 28508
• [(2R,3R,4S,5R,6R)-6-[2-chloro-1-[[(2S,4R)-1-methyl-4-propyl-pyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyl-tetrahydropyran-3-yl] dihydrogen phosphate
• methyl 7-chloro-6,7,8-trideoxy-6-[(1-methyl-4-propylprolyl)amino]-2-O-phosphono-1-thiooctopyranoside
• methyl 7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-2-O-phosphono-1-thio-L-threo-alpha-D-galacto-octopyranoside
• methyl 7-chloro-6,7,8-trideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-2-O-phosphono-1-thiooctopyranoside
• L-threo-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, 2-(dihydrogen phosphate), trans- α-
• L-threo-α-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, 2-(dihydrogen phosphate)
• L-threo-α-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, 2-(dihydrogen phosphate), (2S-trans)-

Clindamycin Phosphate

CAS: 24729-96-2

Formula: C₁₈H₃₄ClN₂O₈PS

Purezza: >97.0%(T)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 504.96

Ref: 3B-C2257

Clindamycin phosphate

CAS: 24729-96-2

Antibiotic U-28508E, effective against Gram-positive bacteria

Formula: C₁₈H₃₄ClN₂O₈PS

Peso molecolare: 504.96

Ref: 02-J63387

CLINDAMYCIN PHOSPHATE FOR SYSTEM SUITABILITY CRS

CAS: 24729-96-2

CLINDAMYCIN PHOSPHATE FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0001680

CLINDAMYCIN PHOSPHATE CRS

CAS: 24729-96-2

CLINDAMYCIN PHOSPHATE CRS

Formula: C₁₈H₃₄ClN₂O₈PS

Colore e forma: White. Whitish. Powder.

Peso molecolare: 504.9629

Ref: 41-C2269000

Clindamycin phosphate

CAS: 24729-96-2

Clindamycin phosphate

Formula: C₁₈H₃₄CIN₂O₈PS

Purezza: 88.2%

Colore e forma: White Solid

Peso molecolare: 608.08182

Ref: 47-419

Clindamycin Phosphate System Suitability (Clindamycin phosphate containing 7-Epiclindamycin phosphate)

CAS: 24729-96-2

Heterocyclic compounds with nitrogen hetero-atom(s) only, excluding aromatic or modified aromatic

Formula: C₁₈H₃₄ClN₂O₈PS

Colore e forma: White Off-White Crystalline Powder

Peso molecolare: 504.1462

Ref: 45-1138019

Clindamycin Phosphate

CAS: 24729-96-2

Antibiotics nesoi

Formula: C₁₈H₃₄ClN₂O₈PS

Colore e forma: White Off-White Crystalline Powder

Peso molecolare: 504.1462

Ref: 45-1138008

Clindamycin phosphate

CAS: 24729-96-2

Clindamycin phosphate: a broad-spectrum chlorinated antibiotic, modified from lincomycin, used topically.

Formula: C₁₈H₃₄ClN₂O₈PS

Purezza: 98.15%

Colore e forma: White Solid

Peso molecolare: 504.96

Ref: TM-T1142

Clindamycin Phosphate

CAS: 24729-96-2

Formula: C₁₈H₃₄ClN₂O₈PS

Purezza: 96%

Colore e forma: Solid

Peso molecolare: 504.9629

Ref: IN-DA003P0M

Clindamycin 2-phosphate

CAS: 24729-96-2

Formula: C₁₈H₃₄ClN₂O₈PS

Purezza: ≥ 758μg/mg (C18H33ClN2O5S, anhydrous)

Colore e forma: White to almost white crystalline powder

Peso molecolare: 504.96

Ref: 7W-GA9308

Clindamycin phosphate

CAS: 24729-96-2

Clindamycin phosphate

Purezza: ≥98%

Peso molecolare: 504.96g/mol

Ref: 54-BUP17355

Clindamycin Phosphate

CAS: 24729-96-2

Clindamycin Phosphate

Purezza: 98%

Peso molecolare: 504.96g/mol

Ref: 54-OR1029062

Clindamycin 2-Phosphate

CAS: 24729-96-2

Formula: C₁₈H₃₄ClN₂O₈PS

Peso molecolare: 504.96

Ref: 4Z-C-5076

Clindamycin Phosphate

Prodotto controllato

CAS: 24729-96-2

Formula: C₁₈H₃₄ClN₂O₈PS

Colore e forma: Neat

Peso molecolare: 504.96

Ref: 86-MM1520.00

Clindamycin phosphate

Prodotto controllato

CAS: 24729-96-2

Formula: C₁₈H₃₄ClN₂O₈PS

Colore e forma: Neat

Peso molecolare: 504.96

Ref: 04-C11670150

Clindamycin Phosphate RS

CAS: 24729-96-2

Colore e forma: White To Pale Yellow-White Solid Crystalline Powder

Ref: 2K-7000240021

Clindamycin 2-Phosphate

CAS: 24729-96-2

Applications A highly water soluble Clindamycin prodrug.
References Ozensoy, O., et al.: J. Enz. Inhibit. Med. Chem., 23, 579 (2008), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Dubina, M., et al.: Arch. Dermatol., 145, 1027 (2009),

Formula: C₁₈H₃₄ClN₂O₈PS

Colore e forma: White

Peso molecolare: 504.96

Ref: TR-C580005

Clindamycin-2-phosphate

CAS: 24729-96-2

Clindamycin-2-phosphate is a lincosamide antibiotic with action on bacterial protein synthesis inhibition and is used for treating serious bacterial infections like skin and respiratory infections.

Formula: C₁₈H₃₄ClN₂O₈PS

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 504.96 g/mol

Ref: 3D-AM20485