CAS 24730-10-7

Mesilato di diidroergocristina

Descrizione:

Mesilato di diidroergocristina è un derivato semisintetico degli alcaloidi dell'ergot, utilizzato principalmente in applicazioni farmacologiche. È caratterizzato dalla sua capacità di agire come vasodilatatore ed è stato studiato per i suoi potenziali effetti neuroprotettivi. Il composto è tipicamente presentato come un sale mesilato, che ne migliora la solubilità e la stabilità in varie formulazioni. Mesilato di diidroergocristina presenta una struttura complessa, con più centri chirali, che contribuiscono alla sua attività biologica. È noto per interagire con i recettori adrenergici e serotoninergici, influenzando il rilascio di neurotrasmettitori e il tono vascolare. La sostanza è spesso utilizzata nel trattamento di condizioni come disturbi vascolari periferici e declino cognitivo associato all'invecchiamento. I profili di sicurezza ed efficacia sono stabiliti attraverso studi clinici, sebbene gli effetti collaterali possano includere disturbi gastrointestinali ed effetti cardiovascolari. Come molti agenti farmacologici, il suo uso dovrebbe essere monitorato da professionisti sanitari per mitigare potenziali reazioni avverse.

Formula: C₃₆H₄₅N₅O₈S

InChI: InChI=1/C35H41N5O5.CH4O3S/c1-20(2)34(37-31(41)23-16-25-24-11-7-12-26-30(24)22(18-36-26)17-27(25)38(3)19-23)33(43)40-28(15-21-9-5-4-6-10-21)32(42)39-14-8-13-29(39)35(40,44)45-34;1-5(2,3)4/h4-7,9-12,18,20,23,25,27-29,36,44H,8,13-17,19H2,1-3H3,(H,37,41);1H3,(H,2,3,4)/t23-,25-,27-,28+,29+,34-,35+;/m1./s1

InChI key: InChIKey=SPXACGZWWVIDGR-SPZWACKZSA-N

SMILES: O[C@@]12N([C@@H](CC3=CC=CC=C3)C(=O)N4[C@]1(CCC4)[H])C(=O)[C@@](NC(=O)[C@@H]5C[C@@]6(C=7C=8C(C[C@]6(N(C)C5)[H])=CNC8C=CC7)[H])(C(C)C)O2.S(C)(=O)(=O)O

Sinonimi:

• (5'Alpha,10Alpha)-5'-Benzyl-12'-Hydroxy-3',6',18-Trioxo-2'-(Propan-2-Yl)-9,10-Dihydroergotaman Methanesulfonate (1:1)
• 5'alpha-Benzyl-9,10alpha-dihydro-12'-hydroxy-2'-isopropylergotaman-3',6',18-trione monomethanesulphonate
• 9,10-Dihydroergocristine methanesulfonate
• Dihydroergocristine methanesulfonate
• Dihydroergocristinmesilat
• Dihydroergocristinmesilat [German]
• Ergocristine, 9,10-dihydro-, monomethanesulfonate (salt)
• Ergocristine, dihydro-, methanesulfonate
• Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-, (5'alpha,10alpha)-, monomethanesulfonate (salt)
• Ergotaman-3′,6′,18-trione, 9,10-dihydro-12′-hydroxy-2′-(1-methylethyl)-5′-(phenylmethyl)-, (5′α,10α)-, methanesulfonate (1:1)
• Ergotaman-3′,6′,18-trione, 9,10-dihydro-12′-hydroxy-2′-(1-methylethyl)-5′-(phenylmethyl)-, (5′α,10α)-, monomethanesulfonate (salt)
• Ergotamane-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-, (5'-alpha,10-alpha)-, monomethanesulfonate (salt)
• GNF Pf 3462
• Unii-Ds7Cl18Uam
• Dihydroergocristine mesylate
• DIHYDROERGOCRISTINE METHANESULFONATE ERG OT ALKALOID, VASOC
• ergotamane-3’,6’,18-trione,9,10-dihydro-12’-hydroxy-2’-(1-methylethyl)-5’-(phe
• Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy- 2'-(1-methylethyl)-5'-(phenylmethyl)-, (5'α,10α)-, monomethanesulfonate (salt)
• (5'α,10α)-9,10-Dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-ergotaman-3',6',18-trionemesylate
• (5,10a)-9,10-Dihydro-12hydroxy-2(1-methylethyl)-5(phenylmethyl)-ergotamane-3618-trionemesylate]
• (5'alpha, 10alpha)-9,10-Dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-ergotaman-3',6',18-trione mesylate
• DIHYDROERGOCRYSTINE METHANESULFONATE SALT
• Dihydroergocristine mesilate (D1945000)
• (5'A,10A)-9,10-DIHYDRO-12'-HYDROXY-2'-(1-METHYLETHYL)-5'-(PHENYLMETHYL)-ERGOTAMAN-3',6',18-TRIONE MESYLATE
• Dihydroergocristine mesilate CRS
• 9,10-dihydro-ergocristinmonomethanesulfonate(salt)
• (5’-alpha,10-alpha)-nylmethyl)monomethanesulfonate(salt)
• dihydroergocristine methanesulfonate salt
• C13168
• Dihydroergotamine Mesilate Impurity E as Mesilate
• Dihydroergotamine Mesilate EP Impurity E as Mesilate

Dihydroergocristine methanesulfonate

CAS: 24730-10-7

5-HT receptor antagonist; partial agonist at adrenergic and dopaminergic receptors

Formula: C₃₆H₄₅N₅O₈S

Colore e forma: White, Powder or crystals or crystalline powder

Peso molecolare: 707.84

Ref: 02-J60638

DIHYDROERGOCRISTINE MESILATE CRS

CAS: 24730-10-7

DIHYDROERGOCRISTINE MESILATE CRS

Formula: C₃₆H₄₅N₅O₈S

Peso molecolare: 707.8362

Ref: 41-D1945000

DIHYDROERGOCRISTINE MESILATE FOR ASSAY CRS

CAS: 24730-10-7

DIHYDROERGOCRISTINE MESILATE FOR ASSAY CRS

Ref: 41-Y0002323

Dihydroergocristine (mesylate)

CAS: 24730-10-7

Formula: C₃₆H₄₅N₅O₈S

Purezza: 99.86%

Colore e forma: Solid

Peso molecolare: 707.8362

Ref: IN-DA002P9C

Dihydroergocristine mesylate

CAS: 24730-10-7

Dihydroergocristine mesylate

Purezza: ≥98%

Peso molecolare: 707.84g/mol

Ref: 54-BUP12047

Dihydroergocristine Mesilate

Prodotto controllato

CAS: 24730-10-7

Formula: C₃₅H₄₁N₅O₅·CH₄O₃S

Colore e forma: Neat

Peso molecolare: 707.84

Ref: 86-MM1812.00

Dihydroergocristine mesylate

CAS: 24730-10-7

DHEC mesylate is a vasodilator and α-adrenergic antagonist used for vascular dementia and as a geroprotector.

Formula: C₃₆H₄₅N₅O₈S

Purezza: 98.9% - 99.65%

Colore e forma: Solid

Peso molecolare: 707.84

Ref: TM-T11043

9,10-Dihydroergocristine Methanesulfonate

CAS: 24730-10-7

Formula: C₃₅H₄₁N₅O₅·CH₄O₃S

Peso molecolare: 611.74 96.10

Ref: 4Z-E-088005

Dihydroergocristine Mesylate

CAS: 24730-10-7

Dihydroergocristine Mesylate

Peso molecolare: 707.84g/mol

Ref: 54-BID1021

9,10-Dihydroergocristine Methanesulfonate

Prodotto controllato

CAS: 24730-10-7

Applications 9,10-Dihydroergocristine Methanesulfonate is an nontoxic and well tolerated drug that exerts agonistic and antagonistic activity on dopaminergic and adrenergic receptors. 9,10-Dihydroergocristine Methanesulfonate is known to exhibit protective properties to the brain against metabolic effects of ischemia by acting at a cellular level.
References Setti, M., et al.: Angiologia., 30, 98 (1978); Brunhofer, G., et al.: Bioorg. Med. Chem., 20, 6669 (2012); Benzi, G., et al.: Neurobiol. Aging., 9, 371 (1988);

Formula: C₃₅H₄₁N₅O₅·CH₄O₃S

Colore e forma: Neat

Peso molecolare: 707.84

Ref: TR-D446440

Dihydroergocristine mesylate

CAS: 24730-10-7

Dihydroergocristine is an anti-hypertensive drug that belongs to the class of pharmacological agents. It is used for the treatment of high blood pressure and has been shown to reduce the risk of stroke in patients with cerebrovascular disease. Dihydroergocristine has been found to inhibit the production of 5-hydroxytryptamine (5-HT) by binding to serotonin receptors in vitro, although its effects on human serum levels have not been determined. This drug also inhibits certain enzymes, such as energy metabolism and protein synthesis. Dihydroergocristine can be administered in a solution or as an injection, depending on the severity of symptoms.

Formula: C₃₆H₄₅N₅O₈S

Purezza: Min. 95%

Colore e forma: Solid

Peso molecolare: 707.84 g/mol

Ref: 3D-FD39334

Dihydroergocristine mesilate

CAS: 24730-10-7

Dihydroergocristine mesilate

Colore e forma: White Solid

Ref: 47-120