CAS 24939-03-5

Poli(I:C)

Descrizione:

Poli(I:C), o acido poliinosinico-policitidico, è una molecola di RNA a doppia catena sintetica che funge da potente immunostimolante. È principalmente riconosciuto per il suo ruolo nel mimare le infezioni virali, attivando così la risposta immunitaria, in particolare attraverso la stimolazione dei recettori tipo Toll (TLRs), specificamente TLR3. Questa attivazione porta alla produzione di varie citochine e interferoni, migliorando le difese antivirali del corpo. Poli(I:C) è spesso utilizzato nella ricerca e nelle applicazioni terapeutiche, incluso lo sviluppo di vaccini e l'immunoterapia contro il cancro, grazie alla sua capacità di indurre una risposta immunitaria robusta. La sostanza è tipicamente caratterizzata dal suo alto peso molecolare ed è solubile in acqua, rendendola adatta per vari saggi biologici. Inoltre, Poli(I:C) può essere modificato per migliorare la sua stabilità e efficacia, ad esempio attraverso l'incorporazione di modifiche chimiche che aumentano la sua resistenza alla degradazione da parte delle nucleasi. In generale, Poli(I:C) è uno strumento prezioso in immunologia e ricerca terapeutica, contribuendo alla nostra comprensione dei meccanismi immunitari e delle potenziali strategie di trattamento.

Formula: (C₁₀H₁₃N₄O₈P)x·(C₉H₁₄N₃O₈P)x

InChI: InChI=1S/C10H13N4O8P.C9H14N3O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,10-;4-,6-,7-,8-/m11/s1

InChI key: InChIKey=ACEVNMQDUCOKHT-ZLOOHWKQSA-N

SMILES: O[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=CN3)O[C@H](COP(=O)(O)O)[C@H]1O.O[C@H]1[C@@H](O[C@H](COP(=O)(O)O)[C@H]1O)N2C(=O)N=C(N)C=C2

Sinonimi:

• 4-amino-1-(5-O-phosphonopentofuranosyl)pyrimidin-2(1H)-one - 9-(5-O-phosphonopentofuranosyl)-3,9-dihydro-6H-purin-6-one (1:1)
• 5'-Cytidylic Acid - 5'-Inosinic Acid (1:1)
• 5′-Cytidylic acid, homopolymer, complex with 5′-inosinic acid homopolymer (1:1)
• 5′-Cytidylic acid, polymers, complex with 5′-inosinic acid polymers (1:1)
• 5′-Inosinic acid homopolymer-5′-cytidylic acid homopolymer complex (1:1)
• 5′-Inosinic acid, homopolymer, complex with 5′-cytidylic acid homopolymer (1:1)
• 5′-Inosinic acid, polymers, complex with 5′-cytidylic acid polymers (1:1)
• NSC 120949
• NSC 123233
• NSC 128576
• Poly I:C
• Poly I:C Polyinosinicacid-polycytidylic acid
• Poly(C).poly(I)
• Poly(C:I)
• Poly(I)-poly(C)
• Poly(I).poly(C) complex
• Poly(cytidylic acid)-poly(inosinic acid)
• Poly(rI)-poly(rC)
• Poly(rI:rC)
• Polycytidylic-polyinosinic acid
• Polycytidysic acid
• Polyinosinate-polycytidylate complex
• Polyinosinate:polycytidylate
• Polyinosine-polycytidylic acid
• Polyinosinic acid-polycytidylic acid
• Polyinosinic acid:polycytidylic acid complex
• Polyinosinic-polycytidylic acid complex

5'-Inosinic acid, homopolymer, complex with 5'-cytidylic acidhomopolymer (1:1)OTHER CA INDEX NAMES:5'-Cytidylic acid, homopolymer, complex with 5'-inosinic acidhomopolymer (1:1)

CAS: 24939-03-5

Formula: C₂₁H₃₅N₇O₁₆P₂

Purezza: 90%

Colore e forma: Solid

Peso molecolare: 703.4874

Ref: IN-DA00I4RN

Polyinosinic-polycytidylic acid

CAS: 24939-03-5

Polyinosinic-polycytidylic acid

Purezza: ≥90%

Ref: 54-BUP06314

Polyinosinic acid-polycytidylic acid sodium salt

CAS: 24939-03-5

Ref: 7W-GC1062

Polyinosinic-polycytidylic acid

CAS: 24939-03-5

Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic double-stranded RNA (dsRNA) analog and an immunostimulant that acts as the most potent IFN inducer.

Formula: (C₁₀H₁₃N₄O₈P)x·(C₉H₁₄N₃O₈P)x

Purezza: 90%

Colore e forma: Solid

Peso molecolare: 671.4

Ref: TM-T23171

Poly(I:C) (~90%)

Prodotto controllato

CAS: 24939-03-5

Applications Poly(I:C) is a toll-like receptor 3 dsRNA inflammatory stimulant.
References Smith, G.A., et al.: PLoS One, 10, e0121072 (2015); Dauletbaev, N., et al.: J. Immunol., 195, 2829 (2015); Broering, R., et al.: J. Viral Hepatitis, 21, 480 (2014); Colapicchioni, V., et al.: J. Mater. Chem. B: Mater. Biol. Med., 3, 7408 (2015)

Formula: H₂(C₁₀H₁₁N₄O₈P)n·H₂(C₉H₁₂N₃O₈P)n

Purezza: ~90%

Colore e forma: Neat

Peso molecolare: 671.40

Ref: TR-P688075

Polyinosinic acid-polycytidylic acid, homopolymer (1:1)

CAS: 24939-03-5

Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex structure.PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations. Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes.We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.
For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'

Formula: (C₁₀H₁₃N₄O₈P)x•(C₉H₁₄N₃O₈P)x

Colore e forma: Powder

Ref: 3D-OP29952

Polyinosinic acid-polycytidylic acid, homopolymer (1:1)

CAS: 24939-03-5

Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex structure.PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations. Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes.We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.
For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'

Formula: (C₁₀H₁₃N₄O₈P)x•(C₉H₁₄N₃O₈P)x

Purezza: (Hplc-Ms) Min. 95.0 Area-%

Ref: 3D-J-030005