CAS 251647-55-9

Guanosina, 5′-O-[bis(4-metossifenil)fenilmetile]-2′-O-(2-metossietile)-N-(2-metil-1-ossopropil)-, 3′-[2-cianoetile N,N-bis(1-metiletil)fosforamidite]

Descrizione:

Guanosina, 5′-O-[bis(4-metossifenil)fenilmetile]-2′-O-(2-metossietile)-N-(2-metil-1-ossopropil)-, 3′-[2-cianoetile N,N-bis(1-metiletil)fosforamidite] è un derivato di nucleoside complesso caratterizzato dalle sue uniche modifiche strutturali che ne migliorano stabilità e reattività. Questo composto presenta uno scheletro di guanosina, che è un nucleoside purinico, modificato nelle posizioni 5′ e 2′ con vari gruppi funzionali, inclusi i moieties di fosforamidito metossifenile e cianoetile. Queste modifiche sono progettate per migliorare le prestazioni del composto in applicazioni come la sintesi di oligonucleotidi e la terapia genica. La presenza del gruppo fosforamidito consente reazioni di accoppiamento efficienti nella sintesi di oligonucleotidi, mentre i gruppi metossilici possono contribuire alla solubilità e stabilità in ambienti biologici. In generale, questo composto esemplifica il design intricato degli analoghi di nucleosidi destinati a migliorare l'efficacia terapeutica e la stabilità nelle applicazioni basate sugli acidi nucleici.

Formula: C₄₇H₆₀N₇O₁₀P

InChI: InChI=1S/C47H60N7O10P/c1-30(2)43(55)51-46-50-42-39(44(56)52-46)49-29-53(42)45-41(60-27-26-57-7)40(64-65(62-25-13-24-48)54(31(3)4)32(5)6)38(63-45)28-61-47(33-14-11-10-12-15-33,34-16-20-36(58-8)21-17-34)35-18-22-37(59-9)23-19-35/h10-12,14-23,29-32,38,40-41,45H,13,25-28H2,1-9H3,(H2,50,51,52,55,56)/t38-,40-,41-,45-,65?/m1/s1

InChI key: InChIKey=LADCDGNEBIQAAU-SBCRAQIVSA-N

SMILES: C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OCCOC)[C@@H](O1)N2C3=C(N=C2)C(=O)N=C(NC(C(C)C)=O)N3)(C4=CC=C(OC)C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6

Sinonimi:

• 2'-O-Methyl-N2-Isobutyryl-5'-O-DMT-Guanosine-3'-CE-Phosphoramidite
• Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
• Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• 22: PN: US20030198965 PAGE: 20 claimed sequence
• 18: PN: US20030211606 PAGE: 20 claimed sequence
• 17: PN: US20030212017 PAGE: 20 claimed sequence
• DMT-2'-O-MOE-G(iBu)-CE-Phosphoramidite
• 5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite
• N2-isobutyryl-5'-O-DMT-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite
• 5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine 3'-CE phosphoramidite
• N2-isobutyryl-5'-O-(4, 4'-dimethoxytrityl)-2'-O- methoxyethyl-guanosine-3'-cyanoethyl Phosphoramidite
• DMT-2μ-O-Me-rG(ib) amidite
• 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O-methylguanosine-3'-(2-cyanoethyl diisopropylphosphoramidite)
• 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• 2'-O-MOE-G(iBu)-CE Phosphoramidite
• 2'-O-MOE-rG(ibu) Phosphoramidite
• 5’-O-(4,4’-Dimethoxy-trityl)-N2-iso-butyroyl-2’-O-(2-methoxyethyl)guanosine-3’-O-[(2-cyanoethyl)(N,N-diisopropyl)]-phosphoramidite
• 5'-O-DMT-N2-isobutyryl-2'-O-?methoxyethylguanosine 3'-CE phosphoramidite
• 2'-MOE-G(iBu)-3'-phosphoramidite
• 2'-O-MOE-ibu-G Phosphoramidite
• DMT-2'-O-MOE-G(iBu)-CEP

DMT-2μ-O-Me-rG(ib) amidite

CAS: 251647-55-9

Formula: C₄₇H₆₀N₇O₁₀P

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 913.9940

Ref: IN-DA00BHUW

5''-O-DMT-N2-isobutyryl-2''-O-methylguanosine 3''-CE phosphoramidite

CAS: 251647-55-9

Ref: 7W-GN5960

Dmt-2'O-Moe-Rg(Ib) Phosphoramidite

CAS: 251647-55-9

Dmt-2'O-Moe-Rg(Ib) Phosphoramidite

Purezza: 98%

Peso molecolare: 913.99g/mol

Ref: 54-OR1029712

DMT-2'-O-MOE-rG(Ib) Phosphoramidite

CAS: 251647-55-9

Formula: C₄₇H₆₀N₇O₁₀P

Purezza: >95.0%(qNMR)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 914.01

Ref: 3B-M3371

2'-MOE-G(iBu)-3'-phosphoramidite

CAS: 251647-55-9

2'-MOE-G(iBu)-3'-phosphoramidite is a Nucleoside Phosphoramidite;Nucleoside Derivative - 2'-Modified nucleoside;.

Formula: C₄₇H₆₀N₇O₁₀P

Colore e forma: Solid

Peso molecolare: 913.99

Ref: TM-TNU0960

5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite

CAS: 251647-55-9

Nucleoside phosphoramidites are used in the synthesis of oligonucleotides. Using a chemical approach allows quick and inexpensive access to custom-made oligonucleotides of the desired sequence. Enzymatic synthesis proceeds in a 5’ to 3’ direction, however the chemical synthesis is usually performed in the opposite direction. 5'-O-DMT-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine 3'-CE phosphoramidite, also known as DMT-2'-O-MOE-G(iBu)-CEP, is a modified guanosine with a 2’-O-(2-methoxyethyl) group, these have been used in the synthesis of oligonucleotides as antisense drugs.

Formula: C₄₇H₆₀N₇O₁₀P

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 913.99 g/mol

Ref: 3D-PD63448

DMT-2’O-MOE-rG(ib) Phosphoramidite

CAS: 251647-55-9

Purezza: 95%

Peso molecolare: 914.01

Ref: 10-F986336