CAS 25316-40-9: Cloridrato di doxorubicina

Descrizione: Cloridrato di doxorubicina è un antibiotico antraciclino comunemente usato nella chemioterapia per il cancro. È caratterizzato dal suo colore rosso brillante ed è noto per la sua potente attività antitumorale. Il composto agisce intercalando il DNA, inibendo così la sintesi degli acidi nucleici e interrompendo la replicazione delle cellule tumorali. La doxorubicina è solubile in acqua e presenta un profilo di solubilità dipendente dal pH, che è importante per la sua formulazione e somministrazione. Il suo meccanismo d'azione implica anche la generazione di radicali liberi, contribuendo ai suoi effetti citotossici. Tuttavia, l'uso della doxorubicina è associato a diversi effetti collaterali, inclusa la cardiotossicità, che limita la sua dose cumulativa. Viene tipicamente somministrata per via endovenosa ed è spesso utilizzata in combinazione con altri agenti chemioterapici per aumentare l'efficacia contro varie malignità, inclusi il cancro al seno, la leucemia e i linfomi. A causa dei suoi significativi benefici terapeutici e dei potenziali rischi, un attento monitoraggio e gestione sono essenziali durante il trattamento.

Formula: C₂₇H₂₉NO₁₁·ClH

InChI: InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

InChI key: InChIKey=MWWSFMDVAYGXBV-RUELKSSGSA-N

SMILES: Cl.O=C1C=2C=CC=C(OC)C2C(=O)C=3C(O)=C4C(=C(O)C13)CC(O)(C(=O)CO)CC4OC5OC(C)C(O)C(N)C5

Sinonimi:

• (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside hydrochloride (1:1)
• (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside hydrochloride (1:1)
• (8S-Cis)-10-((3-Amino-2,3,6-Trideoxy-Alpha-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxynaphthacene-5,12-Dione Hydrochloride
• (8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid
• (8S-cis)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
• (8S-cis)-10-[(3-amino-2,3,6-tridesoxi-α-L-lyxo-hexopiranosil)oxi]-7,8,9,10-tetrahidro-6,8,11-trihidroxi-8-(hidroxiacetil)-1-metoxinaftaceno-5,12-diona, clorhidrato
• (8S-cis)-10-[(3-amino-2,3,6-tridesoxy-α-L-lyxo-hexopyrannosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphtacene-5,12-dione, chlorhydrate
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
• ADM hydrochloride
• ADR
• Adriablastina CS
• Adriacin
• Adriamycin
• Adriamycin, hydrochloride
• Adriblastin
• Adriblastina
• Adriblastina RD
• Adrosal
• Ameisu hydrochloride
• Caelyx pegylated liposomal
• DOX HCl
• Doxolipad
• Doxorubicin, HCl
• Doxorubicin-LANS
• Doxorubicin-TEVA
• Doxourbicin HCl
• Fi 106
• Fi 6804
• Hydroxydaunorubicin hydrochloride
• Lipo-Dox
• Lipodox
• Myocet liposomal
• Doxorubicin hydrochloride

Doxorubicin Hydrochloride

CAS: 23214-92-8 25316-40-9

• Formula: C₂₇H₂₉NO₁₁·HCl
• Purezza: >95.0%(HPLC)
• Colore e forma: Light yellow to Brown powder to crystal
• Peso molecolare: 579.98

Doxorubicin hydrochloride

CAS: 25316-40-9

Antitumor antibiotic agent that inhibits DNA topoisomerase II.Doxorubicin hydrochloride is used as an antineoplastic, antibiotic …

• Formula: C₂₇H₃₀ClNO₁₁
• Colore e forma: Crystalline powder or granular, Red to orange
• Peso molecolare: 579.98

Doxorubicin hydrochloride RS

CAS: 25316-40-9

• Formula: C₂₇H₂₉NO₁₁
• Peso molecolare: 543.5193

Doxorubicin hydrochloride CRS

CAS: 25316-40-9

• Formula: C₂₇H₂₉NO₁₁
• Colore e forma: Crystalline Powder. Orange. Red. Powder.
• Peso molecolare: 543.5193

Doxorubicin hydrochloride

CAS: 25316-40-9

• Formula: C₂₇H₂₉NO₁₁HCl
• Purezza: 99.0%
• Colore e forma: Orange To Dark Red
• Peso molecolare: 579.15074

Doxorubicin Hydrochloride

CAS: 25316-40-9

Antibiotics nesoi

• Formula: C₂₇H₂₉NO₁₁·ClH
• Colore e forma: Red Orange Crystalline Powder Amorphous Powder
• Peso molecolare: 579.15074

Doxorubicin hydrochloride

CAS: 25316-40-9

Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of …

• Formula: C₂₇H₂₉NO₁₁·HCl
• Purezza: 98% - 99.57%
• Colore e forma: Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)
• Peso molecolare: 579.99

(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride

CAS: 25316-40-9

• Formula: C₂₇H₃₀ClNO₁₁
• Purezza: %
• Colore e forma: Solid
• Peso molecolare: 579.9802

Doxorubicin HCl (Daunorubicin EP Impurity D HCl, Epirubicin EP Impurity C HCl)

CAS: 25316-40-9

• Formula: C₂₇H₂₉NO₁₁·HCl
• Colore e forma: Red Solid
• Peso molecolare: 543.53 36.46

Doxorubicin hydrochloride

CAS: 25316-40-9

• Purezza: ≥98%
• Peso molecolare: 579.99g/mol

Doxorubicin hydrochloride

CAS: 25316-40-9

• Formula: C₂₇H₂₉NO₁₁·ClH
• Purezza: 99%
• Colore e forma: orange red crystalline powder
• Peso molecolare: 579.98g/mol

Doxorubicin hydrochloride, 98%

CAS: 25316-40-9

• Formula: C₂₇H₂₉NO₁₁·HCl
• Purezza: (HPLC) 98.0 - 102.0 % (anhydrous, solvent free)
• Colore e forma: Orange-red to red crystalline powder
• Peso molecolare: 579.99

Doxorubicin hydrochloride

CAS: 25316-40-9

• Purezza: 95.0%
• Colore e forma: Solid, Crystalline Powder or Granules or Powder
• Peso molecolare: 579.15073846

Doxorubicin Hydrochloride

CAS: 25316-40-9

• Formula: C₂₇H₂₉NO₁₁·ClH
• Colore e forma: Neat
• Peso molecolare: 579.98

Doxorubicin hydrochloride, USP grade

CAS: 25316-40-9

• Formula: C₂₇H₂₉NO₁₁·HCl
• Purezza: ≥ 98.0% (anhydrous, solvent-free)
• Colore e forma: Orange-red to red crystalline powder
• Peso molecolare: 579.99

Doxorubicin-13C-d3 HCl (Daunorubicin EP Impurity D-13C-d3 HCl, Epirubicin EP Impurity C-13C-d3 HCl)

CAS: 25316-40-9

• Formula: C₁₃C₂₂H₂₆D₃NO₁₁·HCl
• Peso molecolare: 547.56 36.45

Doxorubicin Hydrochloride RS

CAS: 25316-40-9

• Colore e forma: Red-Orange Solid Crystalline Powder

Doxorubicin Hydrochloride

CAS: 25316-40-9

Stability Hygroscopic, Light Sensitive Applications Doxorubicin Hydrochloride is an antineoplastic agent. References Di Marco, A., …

• Formula: C₂₇H₂₉NO₁₁·ClH
• Colore e forma: Neat
• Peso molecolare: 579.98

Doxorubicin hydrochloride - Bio-X ™

CAS: 25316-40-9

Doxorubicin hydrochloride is an inhibitor of topoisomerase II with anti-neoplastic activity and belongs to the …

• Formula: C₂₇H₂₉NO₁₁•HCl
• Purezza: Min. 95%
• Colore e forma: Powder
• Peso molecolare: 579.98 g/mol

Doxorubicin HCl

CAS: 25316-40-9

Inhibitor of topoisomerase II with anti-neoplastic activity. The compound interferes with the topoisomerase II-mediated repair …

• Formula: C₂₇H₂₉NO₁₁·HCl
• Purezza: Min. 98 Area-%
• Colore e forma: Red Powder
• Peso molecolare: 579.98 g/mol