CAS 25316-40-9

Cloridrato di doxorubicina

Descrizione:

Cloridrato di doxorubicina è un antibiotico antraciclino comunemente usato nella chemioterapia per il cancro. È caratterizzato dal suo colore rosso brillante ed è noto per la sua potente attività antitumorale. Il composto agisce intercalando il DNA, inibendo così la sintesi degli acidi nucleici e interrompendo la replicazione delle cellule tumorali. La doxorubicina è solubile in acqua e presenta un profilo di solubilità dipendente dal pH, che è importante per la sua formulazione e somministrazione. Il suo meccanismo d'azione implica anche la generazione di radicali liberi, contribuendo ai suoi effetti citotossici. Tuttavia, l'uso della doxorubicina è associato a diversi effetti collaterali, inclusa la cardiotossicità, che limita la sua dose cumulativa. Viene tipicamente somministrata per via endovenosa ed è spesso utilizzata in combinazione con altri agenti chemioterapici per aumentare l'efficacia contro varie malignità, inclusi il cancro al seno, la leucemia e i linfomi. A causa dei suoi significativi benefici terapeutici e dei potenziali rischi, un attento monitoraggio e gestione sono essenziali durante il trattamento.

Formula: C₂₇H₂₉NO₁₁·ClH

InChI: InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

InChI key: InChIKey=MWWSFMDVAYGXBV-RUELKSSGSA-N

SMILES: OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5.Cl

Sinonimi:

• (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside hydrochloride (1:1)
• (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside hydrochloride (1:1)
• (8S-Cis)-10-((3-Amino-2,3,6-Trideoxy-Alpha-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxynaphthacene-5,12-Dione Hydrochloride
• (8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid
• (8S-cis)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
• (8S-cis)-10-[(3-amino-2,3,6-tridesoxi-α-L-lyxo-hexopiranosil)oxi]-7,8,9,10-tetrahidro-6,8,11-trihidroxi-8-(hidroxiacetil)-1-metoxinaftaceno-5,12-diona, clorhidrato
• (8S-cis)-10-[(3-amino-2,3,6-tridesoxy-α-L-lyxo-hexopyrannosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphtacene-5,12-dione, chlorhydrate
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
• ADM hydrochloride
• ADR
• Adriablastina CS
• Adriacin
• Adriamycin
• Adriamycin, hydrochloride
• Adriblastin
• Adriblastina
• Adriblastina RD
• Adrosal
• Ameisu hydrochloride
• Caelyx pegylated liposomal
• DOX HCl
• Doxolipad
• Doxorubicin, HCl
• Doxorubicin-LANS
• Doxorubicin-TEVA
• Doxourbicin HCl
• Fi 106
• Fi 6804
• Hydroxydaunorubicin hydrochloride
• Lipo-Dox
• Lipodox
• Myocet liposomal

Doxorubicin Hydrochloride

CAS: 23214-92-8, 25316-40-9

Formula: C₂₇H₂₉NO₁₁·HCl

Purezza: >95.0%(HPLC)

Colore e forma: Light yellow to Brown powder to crystal

Peso molecolare: 579.98

Ref: 3B-D4193

Doxorubicin hydrochloride

CAS: 25316-40-9

Doxorubicin hydrochloride, 25316-40-9, also known as Lipodox, is an anthracycline antibiotic with anti-cancer properties. Learn more at Thermo Fisher Scientific.

Formula: C₂₇H₃₀ClNO₁₁

Colore e forma: Crystalline powder or granular, Red to orange

Peso molecolare: 579.98

Ref: 02-J64000

Doxorubicin Hydrochloride

CAS: 25316-40-9

Colore e forma: Neat

Ref: 61-FOR0283.00

DOXORUBICIN HYDROCHLORIDE CRS

CAS: 25316-40-9

DOXORUBICIN HYDROCHLORIDE CRS

Formula: C₂₇H₂₉NO₁₁

Colore e forma: Crystalline Powder. Orange. Red. Powder.

Peso molecolare: 543.5193

Ref: 41-D2975000

Doxorubicin hydrochloride

CAS: 25316-40-9

Doxorubicin hydrochloride

Formula: C₂₇H₂₉NO₁₁HCl

Purezza: 99.0%

Colore e forma: Orange To Dark Red

Peso molecolare: 579.15074

Ref: 47-990

DOXORUBICIN HYDROCHLORIDE RS

CAS: 25316-40-9

DOXORUBICIN HYDROCHLORIDE RS

Formula: C₂₇H₂₉NO₁₁

Peso molecolare: 543.5193

Ref: 41-ICRS0292

Doxorubicin Hydrochloride

CAS: 25316-40-9

Antibiotics nesoi

Formula: C₂₇H₂₉NO₁₁·ClH

Colore e forma: Red Orange Crystalline Powder Amorphous Powder

Peso molecolare: 579.15074

Ref: 45-1225703

(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride

CAS: 25316-40-9

Formula: C₂₇H₃₀ClNO₁₁

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 579.9802

Ref: IN-DA0035W0

Doxorubicin hydrochloride

CAS: 25316-40-9

Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM).

Formula: C₂₇H₂₉NO₁₁·HCl

Purezza: 98% - 99.52%

Colore e forma: Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)

Peso molecolare: 579.99

Ref: TM-T1020

Doxorubicin hydrochloride

CAS: 25316-40-9

Doxorubicin hydrochloride

Purezza: ≥98%

Peso molecolare: 579.99g/mol

Ref: 54-BUP15771

Doxorubicin hydrochloride

CAS: 25316-40-9

Doxorubicin hydrochloride

Formula: C₂₇H₂₉NO₁₁·ClH

Purezza: 99%

Colore e forma: orange red crystalline powder

Peso molecolare: 579.98019g/mol

Ref: 54-BID0120

Doxorubicin hydrochloride, USP grade

CAS: 25316-40-9

Formula: C₂₇H₂₉NO₁₁·HCl

Purezza: ≥ 98.0% (anhydrous, solvent-free)

Colore e forma: Orange-red to red crystalline powder

Peso molecolare: 579.99

Ref: 7W-GA4969

Doxorubicin HCl (Daunorubicin EP Impurity D HCl, Epirubicin EP Impurity C HCl)

CAS: 25316-40-9

Formula: C₂₇H₂₉NO₁₁·HCl

Colore e forma: Red Solid

Peso molecolare: 543.53 36.46

Ref: 4Z-D-341

Doxorubicin hydrochloride, 98%

CAS: 25316-40-9

Formula: C₂₇H₂₉NO₁₁·HCl

Purezza: (HPLC) 98.0 - 102.0 % (anhydrous, solvent free)

Colore e forma: Orange-red to red crystalline powder

Peso molecolare: 579.99

Ref: 7W-GP9056

Doxorubicin Hydrochloride

Prodotto controllato

CAS: 25316-40-9

Formula: C₂₇H₂₉NO₁₁·ClH

Colore e forma: Neat

Peso molecolare: 579.98

Ref: 86-MM0283.00

Doxorubicin-13C-d3 HCl (Daunorubicin EP Impurity D-13C-d3 HCl, Epirubicin EP Impurity C-13C-d3 HCl)

CAS: 25316-40-9

Formula: C₁₃C₂₂H₂₆D₃NO₁₁·HCl

Peso molecolare: 547.56 36.45

Ref: 4Z-D-342

Doxorubicin Hydrochloride RS

CAS: 25316-40-9

Colore e forma: Red-Orange Solid Crystalline Powder

Ref: 2K-7000680021

Doxorubicin Hydrochloride

CAS: 25316-40-9

Formula: C₂₇H₂₉NO₁₁HCl

Peso molecolare: 543.5 : 36.46

Ref: ST-EA-CP-D102000

Doxorubicin Hydrochloride

CAS: 25316-40-9

Stability Hygroscopic, Light Sensitive
Applications Doxorubicin Hydrochloride is an antineoplastic agent.
References Di Marco, A., et al.: Cancer Chemother. Rep., (part 1), 53, 33 (1969); Mihich, E. and Ehrke, M.J.: Transplant. Proc., 16, 499 (1984);

Formula: C₂₇H₂₉NO₁₁·ClH

Colore e forma: Neat

Peso molecolare: 579.98

Ref: TR-D558000

Doxorubicin hydrochloride

CAS: 25316-40-9

Doxorubicin is a cytotoxic drug that belongs to the class of anthracyclines. It is used as an anticancer agent and in the treatment of various types of cancer. Doxorubicin has been shown to inhibit glucose uptake by cells, which may be due to its ability to form disulfide bonds with proteins. Doxorubicin also binds to iron-sulfur clusters, causing cell lysis, which may lead to tumor necrosis. In vitro assays have shown that doxorubicin inhibits drug transporter function, leading to reduced cellular uptake of drugs.

Formula: C₂₇H₂₉NO₁₁•HCl

Purezza: Min. 95%

Peso molecolare: 579.98 g/mol

Ref: 3D-IOX-3765-PI

Doxorubicin hydrochloride - Bio-X ™

CAS: 25316-40-9

Doxorubicin hydrochloride is an inhibitor of topoisomerase II with anti-neoplastic activity and belongs to the class of anthracyclines. It is cytotoxic, and interferes with the topoisomerase II-mediated repair of DNA causing accumulation of mutations. Doxorubicin also leads to the generation of reactive oxygen species (ROS), which further damages DNA as well as proteins and membranes. Doxorubicin is used as a chemotherapy treatment for various types of cancer, including breast cancer, lung cancer, ovarian cancer, and leukaemia. However, the compound presents with a risk of developing cardiomyopathy as well as drug resistance.

Formula: C₂₇H₂₉NO₁₁•HCl

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 579.98 g/mol

Ref: 3D-BD164391

Doxorubicin HCl

CAS: 25316-40-9

Doxorubicin (DOX) is an antineoplastic chemotherapy drug used to treat breast, ovarian and pancreatic cancers. It is an antitumor antibiotic that inhibits DNA topoisomerase II. DOX interferes with the topoisomerase II-mediated repair of DNA causing accumulation of mutations. It also leads to the generation of reactive oxygen species (ROS), which further damage DNA as well as proteins and membranes. However, the compound presents with a risk of developing cardiomyopathy as well as drug resistance. Pegylated liposomal doxorubicin has also been developed to treat breast and ovarian cancers, myeloma, and HIV-related Kaposi’s sarcoma.

Formula: C₂₇H₂₉NO₁₁·HCl

Purezza: Min. 98 Area-%

Colore e forma: Red Powder

Peso molecolare: 579.98 g/mol

Ref: 3D-AD15377

Doxorubicin hydrochloride

CAS: 25316-40-9

Formula: C₂₇H₃₀ClNO₁₁

Purezza: 95.0%

Colore e forma: Solid, Crystalline Powder or Granules or Powder

Peso molecolare: 579.98

Ref: 10-F021790

Doxorubicin hydrochloride, 10 mg/ml aqueous solution

CAS: 25316-40-9

Doxorubicin hydrochloride, 10 mg/ml aqueous solution, is a chemotherapeutic agent, which is an anthracycline antibiotic derived from the bacterium *Streptomyces peucetius var. caesius*. Its mode of action involves the intercalation into DNA, disrupting the replication and transcription processes crucial for cancer cell proliferation. Additionally, it generates free radicals that cause further damage to cellular structures and inhibit topoisomerase II, thereby preventing the unwinding of DNA necessary for replication.

Formula: C₂₇H₂₉NO₁₁•HCl

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 579.98 g/mol

Ref: 3D-AD184265

Des-[(4-Amino-2,3,6-trideoxy-hexapyranosyl)oxy)-1-methyl] 2-Carboxylate Doxorubicin

Prodotto controllato

CAS: 25316-40-9

Formula: C₂₀H₁₂O₇

Colore e forma: Neat

Peso molecolare: 364.305

Ref: TR-D558001

Epirubicin EP Impurity C

CAS: 25316-40-9

Formula: C₂₇H₂₉NO₁₁HCl

Peso molecolare: 543.53 : 36.46

Ref: ST-EA-CP-E117003

Daunorubicin EP Impurity D

CAS: 25316-40-9

Formula: C₂₇H₂₉NO₁₁HCl

Peso molecolare: 543.53 : 36.46

Ref: ST-EA-CP-D104004