CAS 25953-19-9

Cefazolina

Descrizione:

Cefazolina è un antibiotico cefalosporinico di prima generazione, utilizzato principalmente per il trattamento delle infezioni batteriche. È efficace contro una varietà di batteri gram-positivi e alcuni organismi gram-negativi. Cefazolina agisce inibendo la sintesi della parete cellulare batterica, portando alla lisi cellulare e alla morte. Il composto è tipicamente somministrato per iniezione, poiché non viene ben assorbito dal tratto gastrointestinale. La sua struttura chimica include un anello beta-lattamico, essenziale per la sua attività antibatterica. Cefazolina è spesso utilizzato nella profilassi chirurgica e per trattare infezioni come infezioni della pelle e dei tessuti molli, infezioni del tratto urinario e infezioni del tratto respiratorio. È generalmente ben tollerato, ma gli effetti collaterali potenziali possono includere reazioni allergiche, disturbi gastrointestinali e alterazioni nella coagulazione del sangue. Come con tutti gli antibiotici, è fondamentale utilizzare Cefazolina in modo giudizioso per prevenire lo sviluppo di resistenza agli antibiotici. Il suo numero CAS, 25953-19-9, identifica in modo univoco questo composto nelle banche dati chimiche.

Formula: C₁₄H₁₄N₈O₄S₃

InChI: InChI=1S/C14H14N8O4S3/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26)/t9-,12-/m1/s1

InChI key: InChIKey=MLYYVTUWGNIJIB-BXKDBHETSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(CN3C=NN=N3)=O)C2=O)(SCC1CSC=4SC(C)=NN4)[H]

Sinonimi:

• (6R,7R)-3-[[(5-Methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[2-(1H-tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R-trans)-3-[[(5-Methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[(1H-tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[(1H-tetrazol- 1-ylacetyl)amino]-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-, (6R-trans)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[2-(1H-tetrazol-1-yl)acetyl]amino]-, (6R,7R)-
• 7-(1-(1H)-Tetrazolylacetamido)-3-[2-(5-methyl-1,3,4-thiadiazolyl)thiomethyl]-Δ3-cephem-4-carboxylic acid
• 7-(1-(1H)-Tetrazolylacetamido)-3-[2-(5-methyl-1,3,4-thiadiazolyl)thiomethyl]-Δ³-cephem-4-carboxylic acid
• 7-(1H-Tetrazol-1-ylacetamido)-3-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid
• 7-[1-(1H)-tetrazolylacetoamido]-3-[2-(5-methyl-1,3,4-thiadiazolyl)-thiomethyl]-Δ-3-cephem-4-carboxylic acid
• CEZ
• Cefamedin
• Cefamezin
• Cefaprim
• Cefazolin,sodium salt
• Cefazolina
• Cefazoline
• Cephamezine
• Cephazolin
• Cephazolin,sodium salt
• Cephazoline
• Elzogram
• Sefazol
• Zinol
• CEFAZOLIN
• 7-(1-(1h-)-tetrazolylacetamido)-3-[2-(5-methyl-1,3,4-thiadiazolyl)thiomethyl]d
• diazol-2-yl)thio)methyl)-8-oxo-7-(2-(1h-tetrazol-1-yl)acetamido)-
• CEFAZOLIN ACID
• diazol-2-yl)thio)methyl)-8-oxo-7-((1h-tetra
• diazol-2-yl)thio)methyl)-8-oxo-7-(2-(1h-t-
• elta3-cephem-4-carboxylicacid
• (6r-trans)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[(1h-tetr
• CefazoilnV
• Cefazoline sodium sterile IP/Bp
• azol-1-yl)acetyl]-amino]-5-thia-1-azabicylo

Cefazolin Sodium Salt

CAS: 25953-19-9, 27164-46-1

Formula: C₁₄H₁₃N₈NaO₄S₃

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Orange to Green powder to crystal

Peso molecolare: 476.48

Ref: 3B-C2242

CEFAZOLIN CRS

CAS: 25953-19-9

CEFAZOLIN CRS

Formula: C₁₄H₁₄N₈O₄S₃

Peso molecolare: 454.5072

Ref: 41-C0682800

Cefazolin

CAS: 25953-19-9

Antibiotics nesoi

Formula: C₁₄H₁₄N₈O₄S₃

Colore e forma: White Powder

Peso molecolare: 454.51

Ref: 45-1097603

Cefazolin

CAS: 25953-19-9

Formula: C₁₄H₁₄N₈O₄S₃

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 454.5072

Ref: IN-DA007N59

Cefazolin

CAS: 25953-19-9

Cefazolin

Purezza: ≥98%

Peso molecolare: 454.51g/mol

Ref: 54-BUP16461

Cefazolin Impurity 45

CAS: 2101505-58-0, 25953-19-9

Formula: C₁₃H₁₄N₆O₆S

Colore e forma: White To Off-White Solid

Peso molecolare: 382.35

Ref: 4Z-C-9666

Cefazolin

CAS: 25953-19-9

Formula: C₁₄H₁₄N₈O₄S₃

Purezza: ≥ 98.0% (dry basis)

Colore e forma: White to off-white powder

Peso molecolare: 454.51

Ref: 7W-GA2577

Cefazolin 1000 µg/mL in Acetonitrile

Prodotto controllato

CAS: 25953-19-9

Formula: C₁₄H₁₄N₈O₄S₃

Colore e forma: Single Solution

Peso molecolare: 454.51

Ref: 04-A11064090AL-1000

Cefazolin

CAS: 25953-19-9

Cefazolin is a semi-synthetic cephalosporin that has a broad spectrum of antibacterial activity and inhibits the synthesis of bacterial cell walls.

Formula: C₁₄H₁₄N₈O₄S₃

Purezza: 99.51%

Colore e forma: Needles From Aqueous Acetone Solid

Peso molecolare: 454.51

Ref: TM-T8390

Cefazolin RS

CAS: 25953-19-9

Colore e forma: White To Pale Yellowish White Solid Crystalline Powder

Ref: 2K-7000390021

Cefazolin

Prodotto controllato

CAS: 25953-19-9

Applications Cefazolin is an antibacterial compound derived from 7-amino-cephalosporanic acid.
References Kozatani, et al.: Chem. Pharm. Bull., 20, 1105 (1972), Birkhead, H.A., et al.: J. Infect. Dis., 128, 379 (1973), Zappala, A.E., et al.: Anal. Profiles Drug Subs., 4, 1 (1975),

Formula: C₁₄H₁₄N₈O₄S₃

Colore e forma: White To Off-White

Peso molecolare: 454.51

Ref: TR-C242495

Cefazolin

CAS: 25953-19-9

Purezza: 98%

Peso molecolare: 454.5

Ref: 10-F863147

L-Cefazolin

Prodotto controllato

CAS: 25953-19-9

Formula: C₁₄H₁₄N₈O₄S₃

Colore e forma: Neat

Peso molecolare: 454.507

Ref: TR-L242600

Cefazolin, Antibiotic for Culture Media Use Only

CAS: 25953-19-9

Cefazolin is a semi-synthetic, non-beta lactam antibiotic used for the treatment of a variety of bacterial infections. It inhibits cell wall synthesis by binding to one or more of penicillin-binding proteins (PBPs), which are bacterial transpeptidases that crosslink peptidoglycan strands. Cefazolin binds to PBPs present on the surface of all Gram-negative bacteria as well as many Gram-positive bacteria. It is not effective against methicillin-resistant staphylococcus and MRSA unless combined with another antibiotic such as vancomycin or flucloxacillin. A study showed that cefazolin can decrease inflammation and tumor necrosis factor-beta levels in pregnant women with systemic inflammatory disease. It has been tested in the development of an anti-inflammatory agent for use in patients with autoimmune diseases such as rheumatoid arthritis and lupus erythe.

Formula: C₁₄H₁₄N₈O₄S₃

Peso molecolare: 454.51 g/mol

Ref: 3D-W-107209

Cefazolin

CAS: 25953-19-9

Cefazolin is a broad-spectrum antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria. It is an effective cephalosporin antibiotic against both aerobic and anaerobic bacteria. Cefazolin is used in clinical isolates to inhibit the growth of methicillin-resistant staphylococcus, resistant microorganisms, and systemic inflammation. Some studies has shown good results to inhibit tumor necrosis factor-α (TNFα) production in cell culture.

Formula: C₁₄H₁₄N₈O₄S₃

Purezza: Min. 95%

Peso molecolare: 454.51 g/mol

Ref: 3D-AC172185