CAS 26098-04-4

Gentamicina C1a

Descrizione:

Gentamicina C1a è un antibiotico aminoglicosidico derivato dal batterio Micromonospora purpurea. È utilizzato principalmente per trattare varie infezioni batteriche, in particolare quelle causate da batteri Gram-negativi. Gentamicina C1a mostra un ampio spettro di attività antibatterica e agisce inibendo la sintesi proteica nei batteri, portando alla morte cellulare. La sostanza è caratterizzata dalla sua struttura complessa, che include più zuccheri amino e un nucleo di 2-deossiestreptamina. Viene tipicamente somministrato per iniezione a causa della sua scarsa biodisponibilità orale. Gentamicina C1a è noto per il suo potenziale nefrotossico e ototossico, richiedendo un attento monitoraggio della funzione renale e dell'udito durante il trattamento. Il farmaco è spesso utilizzato in combinazione con altri antibiotici per migliorare la sua efficacia e ridurre il rischio di sviluppo di resistenza. La sua farmacocinetica comporta una rapida distribuzione nei tessuti corporei, con una emivita che può variare in base alla funzione renale. In generale, Gentamicina C1a rimane un'opzione critica nell'arsenale contro infezioni gravi, in particolare in contesti ospedalieri.

Formula: C₁₉H₃₉N₅O₇

InChI: InChI=1/C19H39N5O7/c1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17/h8-18,24-27H,3-7,20-23H2,1-2H3

InChI key: InChIKey=VEGXETMJINRLTH-BOZYPMBZSA-N

SMILES: O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)CC[C@H]2N)[C@@H](N)C[C@H]1N)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3

Sinonimi:

• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</smallcap>-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</span>-erythro-hexopyranosyl-(1→4)]-2-deoxy-
• Geneticin C_1a
• Gentamicin C1a
• Gentamicin C_1a
• Gentamicin C₃
• Gentamycin C_1a
• O-3-Deoxy-4-C-methyl-3-(methylamino)-β-<span class="text-smallcaps">L</smallcap>-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</smallcap>-erythro-hexopyranosyl-(1→4)]-2-deoxy-<smallcap>D</span>-streptamine
• Gentamycin C1a
• Gentamicin C3
• O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-D-streptamine
• D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-
• Gentamisin C3
• GentaMycin C1a Acetate
• O-3-Deoxy-4-C-methyl-3-(methylamino)--L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-erythro-hexopyranosyl-(1-4)]-2-deoxy-D-streptamine
• 6-O-(3-Deoxy-4-methyl-3-methylamino-β-L-arabinopyranosyl)-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)-2-deoxy-D-streptamine
• Gentamicin C1a Pentaacetate Salt
• GentaMicin D Acetate
• Geneticin C1a
• Gentamicin D
• O-3-Deoxy-4-C-Methyl-3-(MethylaMino)-β-L-arabinopyranosyl-(1-6)-O-[2,6-diaMino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1-4)]-2-deoxy-D-streptaMine Pentaacetate Salt
• 6-O-[3-Deoxy-4-methyl-3-(methylamino)-β-L-arabinopyranosyl]-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)-2-deoxy-D-streptamine

D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-

CAS: 26098-04-4

Formula: C₁₉H₃₉N₅O₇

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 449.5423

Ref: IN-DA002RNM

Gentamicin C1a

CAS: 26098-04-4

Formula: C₁₉H₃₉N₅O₇

Peso molecolare: 449.55

Ref: 4Z-G-044005

(2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-4,6-Diamino-3-(((2R,3R,6S)-3-Amino-6-(Aminomethyl)Tetrahydro-2H-Pyran-2-Yl)Oxy)-2-Hydroxycyclohexyl)Oxy)-5-Methyl-4-(Methylamino)Tetrahydro-2H-Pyran-3,5-Diol

CAS: 26098-04-4

(2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-4,6-Diamino-3-(((2R,3R,6S)-3-Amino-6-(Aminomethyl)Tetrahydro-2H-Pyran-2-Yl)Oxy)-2-Hydroxycyclohexyl)Oxy)-5-Methyl-4-(Methylamino)Tetrahydro-2H-Pyran-3,5-Diol

Purezza: 98+%

Peso molecolare: 449.54g/mol

Ref: 54-OR1030815

Gentamicin C1a pentaacetate salt

CAS: 26098-04-4

Formula: C₂₉H₅₉N₅O₁₇

Purezza: ≥ 95%

Colore e forma: White to off-white crystalline powder

Peso molecolare: 749.8

Ref: 7W-GA4559

Gentamicin C1a

CAS: 26098-04-4

Gentamicin C1a, a major component with antibacterial activity, is the precursor to Etimicin.

Formula: C₁₉H₃₉N₅O₇

Colore e forma: Solid

Peso molecolare: 449.54

Ref: TM-T74669

Gentamicin C1a Pentaacetate Salt

CAS: 26098-04-4

Stability Hygroscopic
Applications Antibacterial.
References Holt, H.A., et al.: J. Antimicrob. Chemother., 34, 747 (1994), Wilschanski, M., et al.: Am. J. Respir. Crit. Care Med., 161, 860 (2000),

Formula: C₂₉H₅₉N₅O₁₇

Colore e forma: Beige

Peso molecolare: 749.8

Ref: TR-G360590

Gentamicin C1a Deuterated Pentaacetate (>90%)

Prodotto controllato

CAS: 26098-04-4

Formula: C₁₉H₃₉N₅O₇·C₁₀H₂₀O₁₀

Purezza: >90%

Colore e forma: Neat

Peso molecolare: 449.5

Ref: TR-G360592

Gentamicin C1a pentaacetate

CAS: 26098-04-4

Gentamicin C1a pentaacetate is an aminoglycoside antibiotic derivative, which is synthesized through the acetylation of the hydroxyl groups in gentamicin C1a. This compound is derived from the fermentation products of Micromonospora species, a genus of actinobacteria. Its mode of action is similar to that of standard aminoglycosides, primarily involving the binding to bacterial 30S ribosomal subunits. This binding interferes with protein synthesis by causing misreading of mRNA, ultimately leading to the inhibition of protein production and bacterial cell death.

Formula: C₂₉H₅₉N₅O₁₇

Purezza: Min. 95%

Colore e forma: Off-White Powder

Peso molecolare: 749.8 g/mol

Ref: 3D-AG16458

Gentamicin C1a

CAS: 26098-04-4

Gentamicin C1a is an aminoglycoside antibiotic, which is a secondary metabolite derived from the bacterium Micromonospora. This antibiotic functions through a mode of action that involves binding to the 30S subunit of bacterial ribosomes. This binding disrupts protein synthesis by causing misreading of the mRNA, ultimately leading to inhibition of bacterial growth and cellular death.

Formula: C₁₉H₃₉N₅O₇

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 449.54 g/mol

Ref: 3D-AG170748

Gentamicin C1a

CAS: 26098-04-4

Formula: C₁₉H₃₉N₅O₇

Peso molecolare: 449.5

Ref: ST-EA-CP-G33012