CAS 265121-04-8

Fosaprepitant dimeglumina

Descrizione:

Fosaprepitant dimeglumina è un composto sintetico utilizzato principalmente come antiemetico nella prevenzione della nausea e del vomito associati alla chemioterapia. È un pro-farmaco di aprepitant, che agisce come un antagonista selettivo del recettore della neurochinina-1 (NK1), inibendo così l'azione della sostanza P, un neuropeptide coinvolto nel riflesso del vomito. La sostanza è caratterizzata dalla sua alta solubilità in acqua grazie alla presenza del gruppo dimeglumina, che ne migliora la biodisponibilità. Fosaprepitant viene tipicamente somministrato per via endovenosa ed è noto per la sua efficacia in combinazione con altri agenti antiemetici. La sua farmacocinetica include una rapida conversione in aprepitant nel corpo, con una emivita relativamente lunga, che consente effetti antiemetici sostenuti. Gli effetti collaterali comuni possono includere affaticamento, vertigini e disturbi gastrointestinali. Come agente terapeutico, Fosaprepitant dimeglumina gioca un ruolo cruciale nel migliorare la qualità della vita dei pazienti sottoposti a trattamento per il cancro gestendo efficacemente nausea e vomito indotti dalla chemioterapia.

Formula: C₂₃H₂₂F₇N₄O₆P·2C₇H₁₇NO₅

InChI: InChI=1S/C23H22F7N4O6P.C7H17NO5/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38);4-13H,2-3H2,1H3/t12-,19+,20-;4-,5+,6+,7+/m10/s1

InChI key: InChIKey=UGJUJYSRBQWCEK-GGXTVIBHSA-N

SMILES: C(N1[C@H]([C@@H](O[C@H](C)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)OCC1)C3=CC=C(F)C=C3)C4=NN(P(=O)(O)O)C(=O)N4.[C@H]([C@@H]([C@@H](CO)O)O)([C@H](CNC)O)O

Sinonimi:

• 1-Deoxy-1-(Methylamino)-D-Glucitol [3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethoxy]-3-(4-Fluorophenyl)-4-Morpholinyl]Methyl]-2,5-Dihydro-5-Oxo-1H-1,2,4-Triazol-1-Yl]Phosphonate
• <span class="text-smallcaps">D</span>-Glucitol, 1-deoxy-1-(methylamino)-, [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate (2:1)
• <span class="text-smallcaps">D</span>-Glucitol, 1-deoxy-1-(methylamino)-, [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate (2:1) (salt)
• D-Glucitol, 1-deoxy-1-(methylamino)-, (3-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4- morpholinyl)methyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl)phosphonate (2:1) (salt)
• Fosaprepitant di(N-methylglucamine)
• Fosaprepitant dimeglumine [USAN]
• Ivemend
• Mk-0517
• Phosphonic acid, (3-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl)-, compd. with 1-deoxy-1-(methylamino)-D-glucitol (1:2)
• Phosphonic acid, [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-, compd. with 1-deoxy-1-(methylamino)-<span class="text-smallcaps">D</span>-glucitol (1:2)
• Unii-D35Fm8T64X
• Fosaprepitant dimeglumine
• Fosapitant Dimeglumine

Fosaprepitant dimeglumine

CAS: 265121-04-8

Formula: C₃₇H₅₆F₇N₆O₁₆P

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 1004.8337

Ref: IN-DA00BF3G

Fosaprepitant dimeglumine

CAS: 265121-04-8

Fosaprepitant dimeglumine

Purezza: ≥95%

Peso molecolare: 1004.83g/mol

Ref: 54-BUP10189

Fosaprepitant Dimeglumine

CAS: 265121-04-8

Formula: C₂₃H₂₂F₇N₄O₆P·2C₇H₁₇NO₅

Colore e forma: White To Off-White Solid

Peso molecolare: 614.41 2*195.22

Ref: 4Z-F-361

Fosaprepitant-d4 Dimeglumine

CAS: 265121-04-8

Formula: C₂₃H₁₈D₄F₇N₄O₆P·2C₇H₁₇NO₅

Colore e forma: White To Off-White Solid

Peso molecolare: 618.44 2*195.22

Ref: 4Z-F-364

Fosaprepitant Dimeglumine

CAS: 265121-04-8

Formula: C₂₃H₂₂F₇N₄O₆P·2C₇H₁₇NO₅

Purezza: >95.0%(HPLC)(qNMR)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 1,004.84

Ref: 3B-F1355

Fosaprepitant dimeglumine

CAS: 265121-04-8

Fosaprepitant dimeglumine (MK-0517) is a soluble prodrug of aprepitant, which prevents nausea by blocking NK1 receptors.

Formula: C₃₇H₅₆F₇N₆O₁₆P

Purezza: 98% - 99.03%

Colore e forma: Solid

Peso molecolare: 1004.83

Ref: TM-T1790

Fosaprepitant Impurity 10

CAS: 265121-04-8

Formula: C₂₃H₂₂F₇N₄O₇P

Colore e forma: White To Off-White Solid

Peso molecolare: 630.42

Ref: 4Z-F-3617

Fosaprepitant-d4 Dimeglumine

Prodotto controllato

CAS: 265121-04-8

Applications Fosaprepitant-d4 Dimeglumine is a labeled analogue of Fosaprepitant Dimeglumine (F727305), a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.
References Tattersall, F., et al.: Neuropharmacol., 39, 652 (2000), Cocquyt, V., et al.: Eur. J. Canc., 37, 835 (2001), Lasseter, K., et al.: J. Clin. Pharmacol., 47, 834 (2007), Marbury, T., et al.: Anesthes., Analges., 109, 418 (2009),

Formula: C₃₇H₅₂D₄F₇N₆O₁₆P

Colore e forma: Neat

Peso molecolare: 1008.86

Ref: TR-F727307

Bis((2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol); (3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid

CAS: 265121-04-8

Purezza: 98.05%

Peso molecolare: 1004.844

Ref: 10-F979755

Fosaprepitant Dimeglumine

Prodotto controllato

CAS: 265121-04-8

Applications Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.
References Tattersall, F., et al.: Neuropharmacol., 39, 652 (2000), Cocquyt, V., et al.: Eur. J. Canc., 37, 835 (2001), Lasseter, K., et al.: J. Clin. Pharmacol., 47, 834 (2007), Marbury, T., et al.: Anesthes., Analges., 109, 418 (2009),

Formula: C₂₃H₂₂F₇N₄O₆P·2C₇H₁₇NO₅

Colore e forma: White To Off-White

Peso molecolare: 1004.83

Ref: TR-F727305

1-Deoxy-1-(methylamino)-D-glucitol [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]m ethyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate

CAS: 265121-04-8

Fosaprepitant is a drug that belongs to the class of drugs used for chemotherapy. It is a prodrug that is converted in vivo to aprepitant, its active form. Fosaprepitant acts as an antagonist of the neurokinin-1 receptor (NK-1R) and inhibits the binding of substance P, which leads to an anti-inflammatory effect. Fosaprepitant has been shown to inhibit the production of substance P in animal models, leading to a reduction in inflammation. In clinical trials, fosaprepitant has been shown to be safe and well tolerated when used with other drugs such as cisplatin and docetaxel in patients with cancer.

Formula: C₂₃H₂₂F₇N₄O₆P•(C₇H₁₇NO₅)₂

Purezza: Min. 95%

Colore e forma: White To Off-White Solid

Peso molecolare: 1,004.83 g/mol

Ref: 3D-FD46503

Fosaprepitant-13C,15N3 Dimeglumine

Prodotto controllato

CAS: 265121-04-8

Formula: C₃₆CH₅₆F₇N₃N₃O₁₆P

Colore e forma: Neat

Peso molecolare: 1008.82

Ref: TR-F727308