CAS 26833-87-4

Omoharringtonina

Descrizione:

Omoharringtonina, con il numero CAS 26833-87-4, è un alcaloide naturale derivato dalla specie vegetale Cephalotaxus harringtonia. È principalmente conosciuto per il suo ruolo come agente antineoplastico, in particolare nel trattamento di alcuni tipi di leucemia, come la leucemia mieloide acuta (LMA). Il composto agisce inibendo la sintesi proteica, il che porta infine alla soppressione della proliferazione delle cellule tumorali. Omoharringtonina presenta un meccanismo d'azione unico mirato al processo di inizio della traduzione eucariotica, rendendolo distinto da altri agenti chemioterapici. Viene tipicamente somministrato per via endovenosa ed è stato studiato per la sua efficacia in combinazione con altri farmaci chemioterapici. La sostanza è caratterizzata dalla sua complessa struttura molecolare, che include più centri chirali, contribuendo alla sua attività biologica. Sebbene mostri promesse nelle applicazioni cliniche, il suo uso può essere associato a effetti collaterali, tra cui mielosoppressione e disturbi gastrointestinali. La ricerca in corso continua a esplorare il suo potenziale e ottimizzare il suo uso terapeutico in oncologia.

Formula: C₂₉H₃₉NO₉

InChI: InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1

InChI key: InChIKey=HYFHYPWGAURHIV-JFIAXGOJSA-N

SMILES: O(C([C@@](CCCC(C)(C)O)(CC(OC)=O)O)=O)[C@H]1[C@@]2([C@@]3(N(CCC=4C2=CC5=C(C4)OCO5)CCC3)C=C1OC)[H]

Sinonimi:

• (4alpha)-O~3~-[2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine
• 1-((1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H- cyclopenta(a)(1,3)dioxolo(4,5-h)pyrrolo(2,1-b)(3)benzazepin-1-yl) 4-methyl (2R)-2- hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
• Brn 5687925
• Ceflatonin
• Cephalotaxine, 3-[4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate]
• Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester)
• Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester) (9CI)
• Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), (3(R))- (9CI)
• Cephalotaxine, 4-methyl-, 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester)
• Cgx-635
• Myelostat
• Nsc 141633
• Omacetaxine mepesuccinate
• Omacetaxine mepesuccinate [USAN]
• Omapro
• O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine
• Synribo
• Unii-6Fg8041S5B

Omacetaxine Mepesuccinate (Homoharringtonine)

CAS: 26833-87-4

Formula: C₂₉H₃₉NO₉

Colore e forma: White To Off-White Solid

Peso molecolare: 545.63

Ref: 4Z-O-027001

Homoharringtonine

CAS: 26833-87-4

Formula: C₂₉H₃₉NO₉

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 545.62

Ref: 7W-GP6715

Homoharringtonine

CAS: 26833-87-4

Homoharringtonine

Purezza: ≥98%

Peso molecolare: 545.62g/mol

Ref: 54-BUP10774

Homoharringtonine

CAS: 26833-87-4

Formula: C₂₉H₃₉NO₉

Purezza: >98.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 545.63

Ref: 3B-H1775

Homoharringtonine

CAS: 26833-87-4

Formula: C₂₉H₃₉NO₉

Purezza: 95%~99%

Peso molecolare: 545.629

Ref: BP-BP0732

Homoharringtonine

CAS: 26833-87-4

Homoharringtonine (HHT) is an alkaloid combatting myeloid cancers and potentially some myelodysplastic syndromes, may treat leukemia and resistant NSC-LC.

Formula: C₂₉H₃₉NO₉

Purezza: 98.21% - 99.91%

Colore e forma: Off-White Cryst

Peso molecolare: 545.62

Ref: TM-T3380

Homoharringtonine

CAS: 26833-87-4

Natural alkaloid

Formula: C₂₉H₃₉NO₉

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 545.63

Ref: 5G-89708

Homoharringtonine

Prodotto controllato

CAS: 26833-87-4

Applications Homoharringtonine (HHT) combined with some botanical drugs could induce cancer cells to resemble normal cells. HHT was prepared by a semi-synthetic method from Cephalotaxine, a major alkaloid of Cepahlotaxus species through the formation of α-ketoester harringtonine.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Baaske, D., et al.: Antimicrob. Agents Chemother., 12, 298 (1977), Tipping, A., et al.: Leukemia, 16, 2349 (2002), Marin, D., et al.: Cancer, 103, 1850 (2005), Levy, V., et al.: Br. J. Cancer, 95, 253 (2006), de Lavallade, H., et al.: Blood, 2779 (2007),

Formula: C₂₉H₃₉NO₉

Colore e forma: Neat

Peso molecolare: 545.62

Ref: TR-H596500

Homoharringtonine

CAS: 26833-87-4

Homoharringtonine is an alkaloid isolated as an anticancer agent, which is derived from the Cephalotaxus genus of evergreen trees and shrubs. It is specifically extracted from the leaves and bark, traditionally known for its therapeutic applications in Chinese medicine. The mode of action of Homoharringtonine involves the inhibition of protein synthesis. It achieves this by binding to the A-site of the ribosomal subunit, impeding the elongation phase of protein synthesis and thus disrupting cellular proliferation.

Formula: C₂₉H₃₉NO₉

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 545.62 g/mol

Ref: 3D-FH15974

Homoharringtonine - Bio-X ™

CAS: 26833-87-4

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₉H₃₉NO₉

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 545.62 g/mol

Ref: 3D-BH300085

Homoharringtonine

CAS: 26833-87-4

Purezza: 99%

Peso molecolare: 545.629

Ref: 10-F979707