CAS 26921-17-5

Maleato di timololo

Descrizione:

Maleato di timololo è un antagonista beta-adrenergico non selettivo utilizzato principalmente nel trattamento del glaucoma e dell'ipertensione oculare, nonché per condizioni sistemiche come l'ipertensione e alcuni tipi di malattie cardiache. È una polvere cristallina bianca a bianco sporco che è solubile in acqua e ha un intervallo di pH che è tipicamente neutro. La sostanza è un sale formato da timololo, un beta-bloccante, e acido maleico, che ne migliora la solubilità e la stabilità. Maleato di timololo agisce riducendo la pressione intraoculare attraverso la diminuzione della produzione di umore acqueo nell'occhio. I suoi effetti farmacologici includono la riduzione della frequenza cardiaca e della contrattilità miocardica, rendendolo utile nella gestione delle condizioni cardiovascolari. Il composto è generalmente ben tollerato, anche se può causare effetti collaterali come affaticamento, vertigini o problemi respiratori in alcuni pazienti. A causa dei suoi effetti sistemici, si consiglia cautela nei pazienti con condizioni respiratorie o alcuni disturbi cardiovascolari. In generale, Maleato di timololo è un importante agente terapeutico sia in oftalmologia che in cardiologia.

Formula: C₁₃H₂₄N₄O₃S·C₄H₄O₄

InChI: InChI=1/C13H24N4O3S.C4H4O4/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17;5-3(6)1-2-4(7)8/h10,14,18H,4-9H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t10-;/m1./s1

SMILES: O(C[C@H](CNC(C)(C)C)O)C=1C(=NSN1)N2CCOCC2.C(=C\C(O)=O)\C(O)=O

Sinonimi:

• (-)-Timolol maleate
• (2R)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol (2Z)-but-2-enedioate (salt)
• (2R)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
• (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol (2Z)-but-2-enedioate (salt)
• (S)-Timolol hydrogen maleate
• (S)-[1-(1,1dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol maleate
• 1,2,5-Thiadiazole, 2-propanol deriv.
• 2-Propanol, 1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-, (-)-, maleate (1:1) (salt)
• 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (2S)-, (2Z)-2-butenedioate (1:1)
• 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (2S)-, (2Z)-2-butenedioate (1:1) (salt)
• 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (S)-, (Z)-2-butenedioate (1:1) (salt)
• <span class="text-smallcaps">L</span>-Timolol maleate
• Apimol
• Aquanil
• Betim
• Betime
• Blocadren
• Blocanol
• But-2-Enedioic Acid
• Isralol
• Istalol
• Mk 950
• Ocumol
• Ophtamolol
• Optimol
• Proflax
• Rysmon TG
• Temserin
• Tenopt
• Timabak
• Timacar
• Timacor
• Timoftol
• Timohexal
• Timolast
• Timolet
• Timolol LA
• Timolol hydrogen maleate
• Timomann
• Timoptic
• Timoptol
• Timoptol XE
• Timoptol-LA
• Timorom
• Wp 934

Timolol Maleate

CAS: 26839-75-8, 26921-17-5

Formula: C₁₃H₂₄N₄O₃S·C₄H₄O₄

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 432.49

Ref: 3B-T2905

Timolol Maleate 1.0 mg/ml in Methanol (as free base)

CAS: 26921-17-5

Colore e forma: Single Solution

Ref: 61-AMP0440.00-01

Timolol Maleate

CAS: 26921-17-5

Colore e forma: Neat

Ref: 61-FOR0440.00

TIMOLOL MALEATE CRS

CAS: 26921-17-5

TIMOLOL MALEATE CRS

Formula: C₁₇H₂₈N₄O₇S

Colore e forma: Added Modified

Peso molecolare: 432.4918

Ref: 41-T1450000

Timolol maleate

CAS: 26921-17-5

Timolol maleate

Formula: C₁₃H₂₄N₄O₃SC₄H₄O₄

Purezza: 100.0%

Colore e forma: White. To. Off-White

Peso molecolare: 432.16787

Ref: 47-1046

TIMOLOL MALEATE RS

CAS: 26921-17-5

TIMOLOL MALEATE RS

Formula: C₁₇H₂₈N₄O₇S

Peso molecolare: 432.4918

Ref: 41-ICRS47069

TIMOLOL FOR SYSTEM SUITABILITY CRS

CAS: 26921-17-5

TIMOLOL FOR SYSTEM SUITABILITY CRS

Formula: C₁₇H₂₈N₄O₇S

Peso molecolare: 432.4918

Ref: 41-Y0001270

Timolol Maleate

CAS: 26921-17-5

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₃H₂₄N₄O₃S·C₄H₄O₄

Colore e forma: White Powder

Peso molecolare: 432.16787

Ref: 45-1667406

Timolol Maleate

CAS: 26921-17-5

Formula: C₁₃H₂₄N₄O₃S·C₄H₄O₄

Colore e forma: White To Off-White Solid

Peso molecolare: 316.42 116.07

Ref: 4Z-T-681

Timolol maleate salt

CAS: 26921-17-5

Formula: C₁₃H₂₄N₄O₃S·C₄H₄O₄

Purezza: (Titration) 98.0 - 101.0 % (dried basis)

Colore e forma: White to almost white powder or crystals

Peso molecolare: 432.49

Ref: 7W-GP7307

Timolol Maleate

Prodotto controllato

CAS: 26921-17-5

Formula: C₁₃H₂₄N₄O₃S·C₄H₄O₄

Colore e forma: Neat

Peso molecolare: 432.49

Ref: 86-MM0440.00

Timolol hydrogenmaleate

Prodotto controllato

CAS: 26921-17-5

Formula: C₁₃H₂₄N₄O₃S·C₄H₄O₄

Colore e forma: Neat

Peso molecolare: 432.49

Ref: 04-C17583000

(S)-Timolol-d5

CAS: 26921-17-5

Formula: C₁₃H₁₉D₅N₄O₃S

Colore e forma: White To Off-White Solid

Peso molecolare: 321.45

Ref: 4Z-T-6817

Timolol Maleate RS

CAS: 26921-17-5

Colore e forma: White To Pale Yellow-White Solid Crystalline Powder

Ref: 2K-1080500021

Timolol Maleate

CAS: 26921-17-5

Applications Antihypertensive; antiarrhythmic (class II); antianginal; antiglaucoma agent.
References Wasson, et al.: J. Med. Chem., 15, 651 (1972), Franciosa, et al.: Clin. Pharmacol. Ther., 13, 138 (1972), Heel, R.C., et al.: Drugs, 17, 38 (1979), Rofman, B.A., et al.: Hypertension, 2, 643 (1980), Mazzo, D.J., et al.: Anal. Profiles Drug Subs., 16, 641 (1987),

Formula: C₁₃H₂₄N₄O₃S·C₄H₄O₄

Colore e forma: Neat

Peso molecolare: 432.49

Ref: TR-T443710

S-Timolol maleate

Prodotto controllato

CAS: 26921-17-5

S-Timolol maleate is a cardioselective beta blocker that has been shown to lower the diastolic pressure and improve the function of the heart. S-Timolol maleate inhibits the enzyme that converts hydrogen ions into hydroxyl ions, which are necessary for the conversion of fatty acids to energy. It also reduces cardiac rate and blood pressure by inhibiting the transmission of nerve impulses. This drug has been shown to be effective in treating anginal attacks, ventricular dysfunction, and cardiac arrhythmias. S-Timolol maleate also slows down metabolic reactions in cells, which increases resistance to thermal expansion.

Formula: C₁₃H₂₄N₄O₃S·C₄H₄O₄

Purezza: Min. 95%

Colore e forma: White Off-White Powder

Peso molecolare: 432.49 g/mol

Ref: 3D-FB63311

S-Timolol maleate - Bio-X ™

Prodotto controllato

CAS: 26921-17-5

Timolol is an ophthalmic beta-adrenergic blocker that is used to lower the intraocular pressure in patients with glaucoma. It is also used to treat hypertension, as well as other conditions, such as arrhythmias, thyrotoxicosis and angina pectoris. The drug acts by blocking β1-receptors on the surface of heart muscle cells and blood vessels, thereby reducing the workload on the heart and lowering blood pressure.

Formula: C₁₃H₂₄N₄O₃S•C₄H₄O₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 432.49 g/mol

Ref: 3D-BS164420