CAS 2752-65-0

Acido gambogico

Descrizione:

Acido gambogico, con il numero CAS 2752-65-0, è un composto naturale derivato dalla resina dell'albero Garcinia hanburyi, comunemente noto come gamboge. Questo pigmento giallastro è composto principalmente da una miscela complessa di xantoni policiclici. Acido gambogico presenta una gamma di attività biologiche, comprese proprietà anti-infiammatorie, antiossidanti e potenziali anticancerogene, rendendolo di interesse nella ricerca farmaceutica. È caratterizzato dal suo colore giallo ed è solubile in solventi organici, ma ha una solubilità limitata in acqua. Il composto è stato studiato per i suoi effetti su diverse linee cellulari tumorali, mostrando promesse nell'inibire la crescita dei tumori. Inoltre, Acido gambogico è stato utilizzato nella medicina tradizionale, in particolare nel sud-est asiatico, per le sue proprietà terapeutiche. Tuttavia, il suo uso è accompagnato da cautela a causa della potenziale tossicità a concentrazioni più elevate. Nel complesso, Acido gambogico rappresenta un'area significativa di studio nella chimica dei prodotti naturali e nelle sue applicazioni in medicina.

Formula: C₃₈H₄₄O₈

InChI: InChI=1/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23?,27?,36-,37?,38-/m1/s1

InChI key: InChIKey=GEZHEQNLKAOMCA-RRZNCOCZSA-N

SMILES: C(/C=C(\C(O)=O)/C)[C@@]12[C@]34C(C(=O)C=5C(O3)=C(CC=C(C)C)C6=C(C5O)C=C[C@](CCC=C(C)C)(C)O6)=C[C@@](C1=O)(C[C@]4(C(C)(C)O2)[H])[H]

Sinonimi:

• (2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoic acid
• (2Z)-4-[(11R,14aS)-8-hydroxy-3,3,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-7,15-dioxo-3a,4,5,7-tetrahydro-3H,11H-1,5-methanofuro[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-methylbut-2-enoic acid
• 1,5-Methano-1H,3H,11H-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonic acid, 3a,4,5,7-tetrahydro-8-hydroxy-alpha,3,3,11-tetramethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-, (Z)-
• 1,5-Methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthene-1-crotonic acid, 3a,4,5,7-tetrahydro-8-hydroxy-α,3,3,11-tetramethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-, (Z)-
• 2-Butenoic acid, 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, (2Z)-
• 2-Butenoic acid, 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, (2Z)-
• 2-Butenoic acid, 2-methyl-4-[3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, [1R-[1α,1(Z),3aβ,5α,11β,14aS*]]-
• B''-Guttiferin
• Cambogic acid
• R-Gambogic acid
• Ui1907
• beta-Guttiferin
• Gambogic acid
• Gambogic acid, 95%, a caspases activator
• 3,3,11-tetramethyl-13-(3-methyl-2-butenyl)-11-(4-7-tetrahydro-8-hydroxy-alph
• Guttic acid
• β-Guttilactone
• B"-Guttiferrin
• Gambogic acid, 97%(HPLC)
• 1,51,5-Methano-1H,3H,11H-furo(3,4-G)pyrano(3,2-B)xanthene-1-crotonic acid
• cambogicacid
• Beta-Guttiferrin
• R,S-Gambogic acid
• alpha-GaMbogic acid
• BETA-GUTTILACTONE
• Guttatic acid
• (z)-methyl-3-pentenyl)-
• GaMbogic aci
• GUTTATIC ACID
• 1,5-methano-1h,3h,11h-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonicacid,3a,4,5,
• (2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoicacid
• GUTTIC ACID
• 1,5-Methano-1H,3H,11H-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonic acid
• Gambogic acid, >=98%

GAMBOGIC ACID

CAS: 2752-65-0

Formula: C₃₈H₄₄O₈

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 628.7512

Ref: IN-DA00BD9X

Gambogic Acid

CAS: 2752-65-0

Gambogic Acid

Purezza: ≥95%

Peso molecolare: 628.75g/mol

Ref: 54-BUP10107

Gambogic Acid

CAS: 2752-65-0

Gambogic Acid

Purezza: 98%

Peso molecolare: 628.75g/mol

Ref: 54-OR1023023

Gambogic acid

CAS: 2752-65-0

Gambogic acid is a tissue-specific proteasome inhibitor, which has anticancer, anti-inflammatory, and anti-angiogenesis activities. Gambogic acid induces LRIG1 (leucine-rich repeat and Ig-like domain-containing-1) upregulation, which is responsible for EGFR (epidermal growth factor receptor) degradation and its downstream Akt/mTORC1 inhibition.

Formula: C₃₈H₄₄O₈

Purezza: 95%~99%

Peso molecolare: 628.762

Ref: BP-BP0613

Gambogic acid

CAS: 2752-65-0

Formula: C₃₈H₄₄O₈

Purezza: ≥ 98.0%

Colore e forma: Yellow to orange powder

Peso molecolare: 628.75

Ref: 7W-GL8216

Gambogic Acid

CAS: 2752-65-0

Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases.

Formula: C₃₈H₄₄O₈

Purezza: 97.16% - 98.67%

Colore e forma: Solid

Peso molecolare: 628.75

Ref: TM-T6185

R,s-gambogic acid

CAS: 2752-65-0

Oxygen-heterocyclic compound

Formula: C₃₈H₄₄O₈

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 628.76

Ref: 5G-80455

R-gambogic acid

CAS: 2752-65-0

Oxygen-heterocyclic compound

Formula: C₃₈H₄₄O₈

Purezza: ≥ 90.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 628.76

Ref: 5G-85875

Gambogic acid

CAS: 2752-65-0

Gambogic acid is a xanthonoid compound, which is a naturally occurring product derived from the resin of Garcinia hanburyi, a tree found in Southeast Asia. It functions primarily through its apoptotic and anti-proliferative effects on cancer cells. Mechanistically, Gambogic acid binds to transferrin receptors, leading to the disruption of cell survival pathways, inhibition of the NF-kB signaling pathway, and induction of apoptosis by activating caspases and influencing mitochondrial pathways.

Purezza: Min. 95%

Ref: 3D-FG42759