CAS 2753-30-2

Gedunina

Descrizione:

Gedunina è un composto chimico che si verifica naturalmente ed è classificato come un limonoide, derivato principalmente dai semi dell'albero di neem (Azadirachta indica). È noto per le sue diverse attività biologiche, comprese le proprietà antimalariche, antifungine e anticancro. Gedunina presenta una struttura molecolare complessa caratterizzata da più anelli e gruppi funzionali, che contribuiscono ai suoi effetti farmacologici. Il composto ha suscitato interesse nella chimica medicinale a causa delle sue potenziali applicazioni terapeutiche, in particolare nello sviluppo di nuovi agenti antimalarici. Inoltre, il meccanismo d'azione di Gedunina implica l'inibizione di alcuni enzimi e vie critiche per la sopravvivenza dei patogeni, rendendolo un argomento di ricerca nel campo della scoperta di farmaci. La sua solubilità e stabilità in vari solventi possono variare, influenzando la sua biodisponibilità e efficacia. In generale, Gedunina rappresenta un'area significativa di studio per i ricercatori che esplorano prodotti naturali come fonti di composti terapeutici innovativi.

Formula: C₂₈H₃₄O₇

InChI: InChI=1S/C28H34O7/c1-15(29)33-20-13-18-24(2,3)19(30)8-10-25(18,4)17-7-11-26(5)21(16-9-12-32-14-16)34-23(31)22-28(26,35-22)27(17,20)6/h8-10,12,14,17-18,20-22H,7,11,13H2,1-6H3/t17-,18+,20-,21+,22-,25-,26+,27+,28-/m1/s1

InChI key: InChIKey=YJXDGWUNRYLINJ-BHAPSIHVSA-N

SMILES: C[C@]12[C@]34[C@](C)([C@@H](OC(=O)[C@]3(O4)[H])C=5C=COC5)CC[C@@]1([C@]6(C)[C@@](C[C@H]2OC(C)=O)(C(C)(C)C(=O)C=C6)[H])[H]

Sinonimi:

• Gedunin
• 16,17-Seco-24-nor-5α,13α,14β,17α-chola-1,20,22-trien-16-oic acid, 14,15β:21,23-diepoxy-7α,17-dihydroxy-4,4,8-trimethyl-3-oxo-, 16,17-lactone, acetate
• Oxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione, 5-(acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a-decahydro-4b,7,7,10a,12a-pentamethyl-, (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-
• D-Homo-24-nor-17-oxachola-1,20,22-triene-3,16-dione, 7-(acetyloxy)-14,15:21,23-diepoxy-4,4,8-trimethyl-, (5α,7α,13α,14β,15β,17aα)-
• (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a-decahydro-4b,7,7,10a,12a-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione

Gedunin

CAS: 2753-30-2

Formula: C₂₈H₃₄O₇

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 482.5654

Ref: IN-DA00C4IP

Gedunin

CAS: 2753-30-2

Gedunin

Purezza: ≥98%

Peso molecolare: 482.57g/mol

Ref: 54-BUP07233

Gedunin

CAS: 2753-30-2

Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.

Formula: C₂₈H₃₄O₇

Purezza: 99.64% - 99.68%

Colore e forma: Solid

Peso molecolare: 482.57

Ref: TM-T21883

Gedunin

CAS: 2753-30-2

Oxygen-heterocyclic compound

Formula: C₂₈H₃₄O₇

Purezza: ≥ 90.0 % (HPLC)

Peso molecolare: 482.57

Ref: 5G-82370

Gedunin

Prodotto controllato

CAS: 2753-30-2

Stability Hygroscopic
Applications Gedunin is a naturally occurring Hsp90 inhibitor. In vitro, Gedunin induces Hsp90-dependent client protein degradation and displays antiproliferative activity (IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Gedunin exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 μM in parasite development and [3H]-hypoxanthine uptake assays respectively).
References 1. Uddin, Shaikh J., et al., 2007. Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytotherapy research : PTR. 21(8): 757-61. PMID: 174505092. Lee, Sung-Eun., et al., 2008. Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae). Phytomedicine : international journal of phytotherapy and phytopharmacology. 15(6-7): 533-5. PMID: 179134823. Brandt, Gary E L., et al., 2008. Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. Journal of medicinal chemistry. 51(20): 6495-502. PMID: 18816111

Formula: C₂₈H₃₄O₇

Colore e forma: Neat

Peso molecolare: 482.56

Ref: TR-G303503

Gedunin

CAS: 2753-30-2

Gedunin is a pentacyclic triterpenoid compound which is primarily found in the neem tree (Azadirachta indica) and other plants in the Meliaceae family.Gedunin works by inhibiting heat shock proteins (Hsp), which are involved in protein folding and stress responses in cells. It also triggers apoptosis in cancer cells and modulates inflammatory pathways to reduce inflammation.Gedunin is used for its anticancer, antimalarial, antibacterial, antifungal, anti-inflammatory, and neuroprotective properties. It has shown promise in inducing apoptosis in cancer cells, effectively combating malaria parasites, exhibiting antimicrobial properties, reducing inflammation, and potentially benefiting neurodegenerative diseases like Parkinson's.

Formula: C₂₈H₃₄O₇

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 482.57 g/mol

Ref: 3D-XG161760