CAS 27536-56-7

4alfa-forbolo 12,13-didecanoato

Descrizione:

4α-Forbolo 12,13-didecanoato è un derivato sintetico del forbolo, un composto che si trova naturalmente nella resina della pianta Jatropha. Questo chimico è caratterizzato dalla sua struttura, che include uno scheletro di forbolo modificato con due gruppi estere di decanoato nelle posizioni 12 e 13. È noto per il suo ruolo come promotore tumorale e per la sua capacità di attivare la proteina chinasi C (PKC), coinvolta in vari percorsi di segnalazione cellulare. Il composto presenta proprietà lipofile a causa degli esteri di acidi grassi a catena lunga, influenzando la sua solubilità e attività biologica. In ambienti di laboratorio, il 4α-forbolo 12,13-didecanoato è spesso utilizzato nella ricerca per studiare la segnalazione cellulare, la biologia del cancro e i meccanismi di promozione tumorale. Sono necessarie precauzioni di sicurezza quando si maneggia questo composto, poiché può essere biologicamente attivo e potenzialmente pericoloso. In generale, le sue caratteristiche strutturali uniche e le implicazioni biologiche lo rendono un composto significativo nella ricerca biochimica.

Formula: C₄₀H₆₄O₈

InChI: InChI=1/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/m1/s1

InChI key: InChIKey=DGOSGFYDFDYMCW-OEFRVDPMSA-N

SMILES: O(C(CCCCCCCCC)=O)[C@@]12[C@@](C1(C)C)([C@]3([C@](O)([C@H](C)[C@H]2OC(CCCCCCCCC)=O)[C@]4([C@@](O)(CC(CO)=C3)C(=O)C(C)=C4)[H])[H])[H]

Sinonimi:

• (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl didecanoate
• 1,1′-[(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl] didecanoate
• 4a-Phorbol-12,13-didecanoate
• 4α-PDD
• 4α-Phorbol didecanoate
• 5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aα,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-, 9,9a-didecanoate
• 9aH-Cyclopropa[3,4]benz[1,2-e]azulene, decanoic acid deriv.
• Decanoic acid, (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl ester
• Decanoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl ester, [1aR-(1aα,1bβ,4aα,7aα,7bα,8α,9β,9aα)]-
• Decanoic acid, 1,1′-[(1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9aH-cyclopropa[3,4]benz[1,2-e]azulene-9,9a-diyl] ester
• Decanoic acid, 9,9a-diester with 1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aα,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one
• 4ALPHA-PHORBOL 12-13-DICAPRINATE
• Decanoic acid, 1,1A,1B,4,4A,5,7A,7B,8,9-decahydro-4A,7B-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9ah-cyclopropa(3,4)benz(1,2-E)azulene-9,9A-diyl ester, (1ar-(1aalpha,1bbeta,4aalpha,7aalpha,7balpha,8alpha,9beta,9aalpha))-
• 4-alpha-Phorbol 12,13-Didecanoate >99%
• 4alpha-Phorbol 12,13-dideconate
• 4α-phorbol 12-13-dicaprinate
• 4A-PHORBOL 12,13-DIDECANOATE, 99+%
• phorbol (4alpha-) 12,13-didecanoate
• 4ALPHA-PDD
• 4α-Phorbol 12,13-Didecanoate, >99%
• 4α-Phorbol 12-13-dicaprinate, 4αPDD
• 4A-PHORBOL 12,13-DIDECANOATE WEAK PROTEI N KINASE C

4α-Phorbol 12,13-didecanoate

CAS: 27536-56-7

Formula: C₄₀H₆₄O₈

Peso molecolare: 672.93

Ref: 7W-GL3242

4α-Phorbol 12,13-didecanoate

Prodotto controllato

CAS: 27536-56-7

Applications 4α-Phorbol 12,13-didecanoate is an activator of TRPV4.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Formula: C₄₀H₆₄O₈

Colore e forma: Neat

Peso molecolare: 672.93

Ref: TR-P353498

4±-Phorbol 12,13-didecanoate

CAS: 27536-56-7

4α-Phorbol 12,13-didecanoate is a chemical compound known as a phorbol ester, which is derived from croton oil. This compound is part of a class of diterpene esters and is primarily utilized in scientific research due to its role as a potent activator of protein kinase C (PKC).

Formula: C₄₀H₆₄O₈

Purezza: Min. 95%

Peso molecolare: 672.93 g/mol

Ref: 3D-CBA53656

4α-PDD

CAS: 27536-56-7

4alpha-PDD activates transient receptor potential vanilloid 4 (TRPV4) channels and is inactive for signaling through PKC.

Formula: C₄₀H₆₄O₈

Colore e forma: Solid

Peso molecolare: 672.93

Ref: TM-T26386