CAS 2768099-61-0

KRAS G12D inhibitor 25

CAS: 2768099-61-0

KRAS G12D inhibitor 25 (Compound 148) acts as an inhibitor for KRAS G12C and HSP90α, displaying IC50 values of <0.1 μM and 0.1-1 μM respectively. Additionally, it suppresses the proliferation of MIA PaCa-2 and NCI-H358 cell lines, with EC50 values of <0.1 μM and 0.1-1 μM correspondingly. This compound also promotes the degradation of ERBB2, exhibiting a DC50 of 0.1-1 μM.

Formula: C₅₆H₆₂ClN₁₁O₆

Colore e forma: Solid

Peso molecolare: 1020.62

Ref: TM-T201006