CAS 27848-84-6

Nicergolina

Descrizione:

Nicergolina è un composto sintetico classificato come un derivato dell'ergolina, utilizzato principalmente per le sue proprietà neuroprotettive e di potenziamento cognitivo. È noto per la sua capacità di migliorare il flusso sanguigno cerebrale e aumentare l'utilizzo dell'ossigeno nel cervello, rendendolo benefico nel trattamento dei disturbi cognitivi associati all'invecchiamento e a problemi vascolari. Nicergolina presenta una struttura complessa, con un sistema di anelli biciclici caratteristico delle ergoline, ed è generalmente somministrato sotto forma del suo sale mesilato. La sostanza è solubile in acqua e presenta una lipofilia moderata, che le consente di attraversare efficacemente la barriera ematoencefalica. I suoi effetti farmacologici sono attribuiti alla sua azione come antagonista alfa-adrenergico e modulatore dei recettori della serotonina, che contribuiscono ai suoi effetti vasodilatatori. Nicergolina è generalmente ben tollerato, con un profilo di effetti collaterali che può includere vertigini, disturbi gastrointestinali e mal di testa. Grazie alle sue proprietà di potenziamento cognitivo, è stato esplorato in vari contesti clinici, in particolare nella gestione della demenza e di altri deficit cognitivi.

Formula: C₂₄H₂₆BrN₃O₃

InChI: InChI=1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1

InChI key: InChIKey=YSEXMKHXIOCEJA-FVFQAYNVSA-N

SMILES: O(C)[C@@]12C=3C=4C(C[C@]1(N(C)C[C@H](COC(=O)C=5C=C(Br)C=NC5)C2)[H])=CN(C)C4C=CC3

Sinonimi:

• (+)-10-Methoxy-1,6-dimethylergoline-8-beta-methanol 5-bromonicotinate
• (10-Methoxy-1,6-Dimethylergolin-8-Yl)Methyl 5-Bromopyridine-3-Carboxylate
• (8β)-10-Methoxy-1,6-dimethylergoline-8-methanol-5-bromo-3-pyridinecarboxylate ester
• 1,6-Dimethyl-8β-(5-bromonicotinoyloxymethyl)-10α-methoxyergoline
• 1-Methyl-lumilysergol 8-(5-bromonicotinate) 10-methyl ether
• 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat)
• 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat) [German]
• 10-Methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyrindinecarboxylate (ester)
• 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate
• 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate (ester)
• 8-beta-((5-Bromonicotinoyloxy)methyl)-1,6-dimethyl-10-alpha-methoxyergoline
• Brn 4828393
• Cergodum
• Circo-Maren
• Dilasenil
• Duracebrol
• Ergobel
• Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester)
• Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester)
• Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, (8beta)-, 5-bromo-3-pyridinecarboxylate (ester)
• Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)-
• Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8β)-
• Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8β)-
• Ergoline-8beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester) (8CI)
• Ergoline-8β-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester)
• Ergotop
• Fi 6714
• Indolo[4,3-fg]quinoline, ergoline-8-methanol deriv.
• MNE
• Memoq
• Nicergolent
• Nicergolin
• Nicergolin [German]
• Nicergolina
• Nicergolina [DCIT]
• Nicergoline [USAN:INN:BAN:JAN]
• Nicergolinum
• Nicergolinum [INN-Latin]
• Nicotergoline
• Nicotinic acid, 5-bromo-, (10-methoxy-1,6-dimethylergolin-8β-yl)methyl ester
• Nimergoline
• Nimergoline base
• Nsc 150531
• Rp 19651
• Sermion
• Ta 079
• Unii-Jcv8365Fwn
• Vasospan
• [(8Beta)-10-Methoxy-1,6-Dimethylergolin-6-Ium-8-Yl]Methyl 5-Bromopyridine-3-Carboxylate

Nicergoline

CAS: 27848-84-6

Formula: C₂₄H₂₆BrN₃O₃

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 484.39

Ref: 3B-N0904

Nicergoline

CAS: 27848-84-6

Nicergoline is an ergot derivative and vasodilator which increases blood flow in the brain. Nicergoline inhibits the vasoconstrictor effect of catecholamines by inhibiting the postsynaptic 1-adrenoceptors on vascular smooth muscle. This Thermo Scientific Chemicals brand product was originally part

Formula: C₂₄H₂₇BrN₃O₃

Colore e forma: White to yellow, Powder or granular powder

Peso molecolare: 485.40

Ref: 02-J63295

Nicergoline

CAS: 27848-84-6

Colore e forma: Neat

Ref: 61-FOR0115.00

NICERGOLINE CRS

CAS: 27848-84-6

NICERGOLINE CRS

Formula: C₂₄H₂₆BrN₃O₃

Colore e forma: Powder

Peso molecolare: 484.3855

Ref: 41-Y0001373

NICERGOLINE FOR SYSTEM SUITABILITY CRS

CAS: 27848-84-6

NICERGOLINE FOR SYSTEM SUITABILITY CRS

Formula: C₂₄H₂₆BrN₃O₃

Colore e forma: Powder

Peso molecolare: 484.3855

Ref: 41-Y0001352

NICERGOLINE FOR PEAK IDENTIFICATION CRS

CAS: 27848-84-6

NICERGOLINE FOR PEAK IDENTIFICATION CRS

Formula: C₂₄H₂₆BrN₃O₃

Colore e forma: Powder

Peso molecolare: 484.3855

Ref: 41-Y0001362

Nicergoline

CAS: 27848-84-6

Nicergoline (Nicergolinum) is an ergot derivative used to treat senile dementia and other disorders with vascular origins.

Formula: C₂₄H₂₆BrN₃O₃

Purezza: 98% - 99.80%

Colore e forma: Solid

Peso molecolare: 484.39

Ref: TM-T1132

Nicergoline

CAS: 27848-84-6

Nicergoline

Purezza: ≥98%

Peso molecolare: 484.39g/mol

Ref: 54-BUP17151

Nicergoline-13C-d3

CAS: 27848-84-6

Formula: C₂₃₁₃CH₂₃D₃BrN₃O₃

Colore e forma: White To Off-White Solid

Peso molecolare: 488.40

Ref: 4Z-N-070001

Nicergoline

CAS: 27848-84-6

Formula: C₂₄H₂₆BrN₃O₃

Colore e forma: White To Off-White Solid

Peso molecolare: 484.39

Ref: 4Z-N-070010

Nicergoline-N1-13C-d3

CAS: 27848-84-6

Formula: C₂₃₁₃CH₂₃D₃BrN₃O₃

Peso molecolare: 488.40

Ref: 4Z-N-070016

Nicergoline

CAS: 27848-84-6

Formula: C₂₄H₂₆BrN₃O₃

Purezza: 98.5 - 102.0 % (anhydrous basis)

Colore e forma: White to off-white or light-yellow powder

Peso molecolare: 484.39

Ref: 7W-GP2573

Nicergoline

CAS: 27848-84-6

Nicergoline

Purezza: 98%

Peso molecolare: 484.39g/mol

Ref: 54-OR1029117

Nicergoline

CAS: 27848-84-6

Colore e forma: Neat

Ref: 86-MM0115.00

Nicergoline-d3

Prodotto controllato

CAS: 27848-84-6

Applications Nicergoline-d3 is the labeled analogue of Nicergoline(N394550), a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia.
References Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)

Formula: C₂₄D₃H₂₃BrN₃O₃

Colore e forma: Neat

Peso molecolare: 487.404

Ref: TR-N394552

Nicergoline

Prodotto controllato

CAS: 27848-84-6

Applications Nicergoline is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.
References Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)

Formula: C₂₄H₂₆BrN₃O₃

Colore e forma: White To Off-White

Peso molecolare: 484.39

Ref: TR-N394550

Nicergoline - Bio-X ™

CAS: 27848-84-6

Nicergoline is an ergot derivative drug that is used for the treatment of any symptoms associated with cerebrovascular abnormalities. This drug works by inhibiting alpha-1 adrenoreceptors on vascular smooth muscles which results in peripheral vasodilation. Furthermore, this drug has been suggested to ameliorate cognitive deficits.

Formula: C₂₄H₂₆BrN₃O₃

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 484.39 g/mol

Ref: 3D-BN166697

Nicergoline

CAS: 27848-84-6

α1-adrenoceptor antagonist; inhibitor of platelet aggregation; antioxidant

Formula: C₂₄H₂₆BrN₃O₃

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 484.4 g/mol

Ref: 3D-FB01518

Nicergoline N-Dimer

Prodotto controllato

CAS: 27848-84-6

Formula: C₄₇H₄₈Br₂N₆O₆

Colore e forma: Neat

Peso molecolare: 952.73

Ref: TR-N394560

Nicergoline 1.0 mg/ml in Acetonitrile

CAS: 27848-84-6

Colore e forma: Single Solution

Ref: 61-AMP0115.00-11