CAS 27848-84-6: Nicergolina

Descrizione: Nicergolina è un composto sintetico classificato come un derivato dell'ergolina, utilizzato principalmente per le sue proprietà neuroprotettive e di potenziamento cognitivo. È noto per la sua capacità di migliorare il flusso sanguigno cerebrale e aumentare l'utilizzo dell'ossigeno nel cervello, rendendolo benefico nel trattamento dei disturbi cognitivi associati all'invecchiamento e a problemi vascolari. Nicergolina presenta una struttura complessa, con un sistema di anelli biciclici caratteristico delle ergoline, ed è generalmente somministrato sotto forma del suo sale mesilato. La sostanza è solubile in acqua e presenta una lipofilia moderata, che le consente di attraversare efficacemente la barriera ematoencefalica. I suoi effetti farmacologici sono attribuiti alla sua azione come antagonista alfa-adrenergico e modulatore dei recettori della serotonina, che contribuiscono ai suoi effetti vasodilatatori. Nicergolina è generalmente ben tollerato, con un profilo di effetti collaterali che può includere vertigini, disturbi gastrointestinali e mal di testa. Grazie alle sue proprietà di potenziamento cognitivo, è stato esplorato in vari contesti clinici, in particolare nella gestione della demenza e di altri deficit cognitivi.

Formula: C₂₄H₂₆BrN₃O₃

InChI: InChI=1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1

InChI key: InChIKey=YSEXMKHXIOCEJA-FVFQAYNVSA-N

SMILES: O=C(OCC1CN(C)C2CC3=CN(C4=CC=CC(=C43)C2(OC)C1)C)C=5C=NC=C(Br)C5

Sinonimi:

• (+)-10-Methoxy-1,6-dimethylergoline-8-beta-methanol 5-bromonicotinate
• (10-Methoxy-1,6-Dimethylergolin-8-Yl)Methyl 5-Bromopyridine-3-Carboxylate
• (8β)-10-Methoxy-1,6-dimethylergoline-8-methanol-5-bromo-3-pyridinecarboxylate ester
• 1,6-Dimethyl-8β-(5-bromonicotinoyloxymethyl)-10α-methoxyergoline
• 1-Methyl-lumilysergol 8-(5-bromonicotinate) 10-methyl ether
• 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat)
• 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat) [German]
• 10-Methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyrindinecarboxylate (ester)
• 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate
• 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate (ester)
• 8-beta-((5-Bromonicotinoyloxy)methyl)-1,6-dimethyl-10-alpha-methoxyergoline
• Brn 4828393
• Cergodum
• Circo-Maren
• Dilasenil
• Duracebrol
• Ergobel
• Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester)
• Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester)
• Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, (8beta)-, 5-bromo-3-pyridinecarboxylate (ester)
• Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)-
• Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8β)-
• Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8β)-
• Ergoline-8beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester) (8CI)
• Ergoline-8β-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester)
• Ergotop
• Fi 6714
• Indolo[4,3-fg]quinoline, ergoline-8-methanol deriv.
• MNE
• Memoq
• Nicergolent
• Nicergolin
• Nicergolin [German]
• Nicergolina
• Nicergolina [DCIT]
• Nicergoline [USAN:INN:BAN:JAN]
• Nicergolinum
• Nicergolinum [INN-Latin]
• Nicotergoline
• Nicotinic acid, 5-bromo-, (10-methoxy-1,6-dimethylergolin-8β-yl)methyl ester
• Nimergoline
• Nimergoline base
• Nsc 150531
• Rp 19651
• Sermion
• Ta 079
• Unii-Jcv8365Fwn
• Vasospan
• [(8Beta)-10-Methoxy-1,6-Dimethylergolin-6-Ium-8-Yl]Methyl 5-Bromopyridine-3-Carboxylate
• [(8Beta)-10-Methoxy-1,6-Dimethylergolin-8-Yl]Methyl 5-Bromopyridine-3-Carboxylate

Nicergoline

CAS: 27848-84-6

Nicergoline is an ergot derivative and vasodilator which increases blood flow in the brain. Nicergoline …

• Formula: C₂₄H₂₇BrN₃O₃
• Colore e forma: White to yellow, Powder or granular powder
• Peso molecolare: 485.40

Nicergoline CRS

CAS: 27848-84-6

• Formula: C₂₄H₂₆BrN₃O₃
• Colore e forma: Powder
• Peso molecolare: 484.3855

Nicergoline for system suitability CRS

CAS: 27848-84-6

• Formula: C₂₄H₂₆BrN₃O₃
• Colore e forma: Powder
• Peso molecolare: 484.3855

Nicergoline for peak identification CRS

CAS: 27848-84-6

• Formula: C₂₄H₂₆BrN₃O₃
• Colore e forma: Powder
• Peso molecolare: 484.3855

Nicergoline

CAS: 27848-84-6

Nicergoline (Nicergolinum) is an ergot derivative used to treat senile dementia and other disorders with …

• Formula: C₂₄H₂₆BrN₃O₃
• Purezza: 100% - 99.53%
• Colore e forma: Solid
• Peso molecolare: 484.39

Nicergoline

CAS: 27848-84-6

• Purezza: ≥98%
• Peso molecolare: 484.39g/mol

Nicergoline

CAS: 27848-84-6

• Peso molecolare: 484.39g/mol

Nicergoline-13C-d3

CAS: 27848-84-6

• Formula: C₂₃₁₃CH₂₃D₃BrN₃O₃
• Colore e forma: White To Off-White Solid
• Peso molecolare: 488.40

Nicergoline

CAS: 27848-84-6

• Formula: C₂₄H₂₆BrN₃O₃
• Colore e forma: White To Off-White Solid
• Peso molecolare: 484.39

Nicergoline

CAS: 27848-84-6

• Formula: C₂₄H₂₆BrN₃O₃
• Purezza: 98.5 - 102.0 % (anhydrous basis)
• Colore e forma: White to off-white or light-yellow powder
• Peso molecolare: 484.39

Nicergoline

CAS: 27848-84-6

• Formula: C₂₄H₂₆BrN₃O₃
• Purezza: >98.0%(T)(HPLC)
• Colore e forma: White to Light yellow powder to crystal
• Peso molecolare: 484.39

Nicergoline

CAS: 27848-84-6

• Formula: C₂₄H₂₆BrN₃O₃
• Colore e forma: Neat
• Peso molecolare: 484.39

Nicergoline-N1-13C-d3

CAS: 27848-84-6

• Formula: C₂₃₁₃CH₂₃D₃BrN₃O₃
• Peso molecolare: 488.40

Nicergoline-d3

CAS: 27848-84-6

Applications Nicergoline-d3 is the labeled analogue of Nicergoline(N394550), a drug used for age-dependent cognitive impairment …

• Formula: C₂₄D₃H₂₃BrN₃O₃
• Colore e forma: Neat
• Peso molecolare: 487.404

Nicergoline

CAS: 27848-84-6

Applications Nicergoline is a drug used for age-dependent cognitive impairment such as Alzheimers disease and …

• Formula: C₂₄H₂₆BrN₃O₃
• Colore e forma: White To Off-White
• Peso molecolare: 484.39

Nicergoline - Bio-X ™

CAS: 27848-84-6

Nicergoline is an ergot derivative drug that is used for the treatment of any symptoms …

• Formula: C₂₄H₂₆BrN₃O₃
• Purezza: Min. 95%
• Colore e forma: Powder
• Peso molecolare: 484.39 g/mol

Nicergoline

CAS: 27848-84-6

α1-adrenoceptor antagonist; inhibitor of platelet aggregation; antioxidant

• Formula: C₂₄H₂₆BrN₃O₃
• Purezza: Min. 95%
• Colore e forma: White Powder
• Peso molecolare: 484.4 g/mol

Nicergoline N-Dimer

CAS: 27848-84-6

• Formula: C₄₇H₄₈Br₂N₆O₆
• Colore e forma: Neat
• Peso molecolare: 952.73