CAS 28002-70-2

Solfato di framicetina

Descrizione:

Solfato di framicetina, con il numero CAS 28002-70-2, è un antibiotico aminoglicosidico derivato dal batterio *Bacillo di Friedländer*. È utilizzato principalmente per le sue proprietà antibatteriche, in particolare contro i batteri Gram-negativi. La sostanza è caratterizzata dalla sua capacità di inibire la sintesi proteica batterica legandosi alla subunità ribosomiale 30S, interrompendo così il processo di traduzione. Solfato di framicetina è spesso utilizzato in formulazioni topiche per trattare infezioni cutanee ed è presente anche in alcune preparazioni oftalmiche. È solubile in acqua e presenta un profilo di tossicità relativamente basso quando applicato topicamente. Tuttavia, come altri aminoglicosidi, può comportare rischi di ototossicità e nefrotossicità se utilizzato sistemicamente. La forma solfato ne migliora la solubilità e stabilità, rendendola adatta per applicazioni farmaceutiche. Come per qualsiasi antibiotico, l'emergere di resistenza è una preoccupazione, richiedendo una considerazione attenta del suo uso in contesti clinici.

Formula: C₂₃H₄₆N₆O₁₃·xH₂O₄S

InChI: InChI=1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

InChI key: InChIKey=OIXVKQDWLFHVGR-WQDIDPJDSA-N

SMILES: S(=O)(=O)(O)O.O([C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H](CO)O2)[C@@H](O)[C@H](N)C[C@@H]1N)[C@H]4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N

Sinonimi:

• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:?)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (salt)
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-O-beta-D-ribofuranosyl-(1-5)-O-(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4))-2-deoxy-, sulfate (salt)
• Framycetin sulfate
• Framycin sulfate
• Neomycin B, sulfate (salt)
• Unii-Y3720Kz4Tq
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (salt)
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:?)

SECOND INTERNATIONAL STANDARD FOR NEOMYCIN B

CAS: 28002-70-2

SECOND INTERNATIONAL STANDARD FOR NEOMYCIN B

Ref: 41-ISA_46104

Neomycin B

CAS: 28002-70-2

Aminoglycoside antibiotics

Formula: C₂₃H₄₆N₆O₁₃·xH₂SO₄

Colore e forma: White Off-White Fine Powder

Peso molecolare: 614.65 (free base)

Ref: 45-1458019

Framycetin sulfate

CAS: 28002-70-2

Formula: C₂₃H₄₈N₆O₁₇S

Colore e forma: Solid

Peso molecolare: 712.7222

Ref: IN-DA01X4WA

Neomycin B Sulfate

CAS: 28002-70-2

Stability Hygroscopic
Applications Neomycin B Trisulfate is a trisulfate salt analog of Neomycin B (N389983), which is an aminoglycoside antibiotic.
References Quader, S., et al.: J. Org. Chem., 72, 1962 (2007);

Formula: C₂₃H₄₆N₆O₁₃·H₂O₄S

Colore e forma: Neat

Peso molecolare: 712.72

Ref: TR-N390043

Neomycin B Sulphate

CAS: 28002-70-2

Formula: C₂₃H₄₆N₆O₁₃X(H₂O₄S)

Peso molecolare: 614.65 : X(98.07)

Ref: ST-EA-CP-N53011

Framycetin sulphate

CAS: 119-04-0, 28002-70-2, 4146-30-9

Framycetin sulphate is a broad-spectrum antibiotic that is used to treat microbial infections. It has been shown to be effective against many gram-positive and gram-negative bacteria, including methicillin resistant Staphylococcus aureus. Framycetin sulphate prevents bacterial growth by inhibiting protein synthesis through binding to the 30S ribosomal subunit. This binding inhibits the incorporation of amino acids into proteins, thereby preventing the production of new proteins required for cell division and growth. Framycetin sulphate also has preservative properties, which may be due to its ability to chelate metal ions such as copper and iron. Framycetin sulphate can be administered orally or topically in vivo model studies. The drug was not found to have any significant toxic effects on the liver or kidneys in vivo model studies at concentrations up to 40%.

Formula: C₂₃H₅₂N₆O₂₅S₃

Purezza: Min. 95%

Peso molecolare: 908.88 g/mol

Ref: 3D-FF150536