CAS 284462-37-9

4-(4-Aminofenossi)-N-metilpicolinamide

Descrizione:

4-(4-Aminofenossi)-N-metilpicolinamide, identificato dal suo numero CAS 284462-37-9, è un composto chimico che presenta una struttura di picolinamide con un gruppo aminofenossi. Questo composto tipicamente mostra caratteristiche come essere un solido a temperatura ambiente, con potenziali applicazioni in chimica medicinale grazie ai suoi motivi strutturali che possono interagire con bersagli biologici. La presenza del gruppo amminico suggerisce che potrebbe partecipare a legami idrogeno, migliorando la sua solubilità in solventi polari. Inoltre, il gruppo metile sull'atomo di azoto può influenzare la sua lipofilia e le proprietà farmacocinetiche complessive. Il composto può anche mostrare specifici schemi di reattività tipici delle amidi e dei composti aromatici, rendendolo di interesse per ulteriori ricerche nello sviluppo di farmaci o come sonda chimica in studi biologici. La sua sintesi e caratterizzazione comporterebbero tecniche standard di chimica organica, e la sua stabilità e reattività dipenderebbero dalle condizioni circostanti, come pH e temperatura.

Formula: C₁₃H₁₃N₃O₂

InChI: InChI=1S/C13H13N3O2/c1-15-13(17)12-8-11(6-7-16-12)18-10-4-2-9(14)3-5-10/h2-8H,14H2,1H3,(H,15,17)

InChI key: InChIKey=RXZZBPYPZLAEFC-UHFFFAOYSA-N

SMILES: O(C=1C=C(C(NC)=O)N=CC1)C2=CC=C(N)C=C2

Sinonimi:

• 2-Pyridinecarboxamide, 4-(4-aminophenoxy)-N-methyl-
• 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide
• 4-(4-Aminophenoxy)-N-methylpicolin Amide
• 4-(4-Aminophenoxy)pyridine-2-carboxylic acid methylamide
• 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
• 4-[2-(N-Methylcarbamyl)-4-pyridyloxy]aniline
• 4-[[2-(Methylcarbamoyl)pyridin-4-yl]oxy]aniline
• 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]aniline
• 4-[[2-(N-Methylcarbamoyl)pyridin-4-yl]oxy]aniline
• N-Methyl-4-(4-aminophenoxy)pyridine-2-carboxamide
• [4-(4-Aminophenoxy)(2-Pyridyl)]-N-Methylcarboxamide
• [4-(4-Aminophenoxy-2-pyridyl)]
• 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide oxalate
• 4-(4-Aminophenyloxy)-N-methyl-2-pyridininecarboxamide
• Sorafenib INT2
• 4-(4-Aminophenoxy)-N-methylpicolinamide
• 4-(4-aMiNApheNAxy)-N-MethylpicolinaMide
• [4-(4-Aminophenoxy-2-pyridyl)]-2-methylcarboxamide
• 4-(4- aMinophenoxy)-N- Methyl-2- pyridineforMaMide
• 4-(4-AMinophenoxy)-pyridine-2-carboxylic acid aMide
• Sorafenib impurity A
• 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]anilin
• 4-(4-Aminophenoxy)-N-methylpicolimide
• 4-(4-AMino-phenoxy)-pyridine-2-carboxylicacidMethylaMide

4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide

CAS: 284462-37-9

Formula: C₁₃H₁₃N₃O₂

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Light yellow to Light orange powder to crystalline

Peso molecolare: 243.27

Ref: 3B-A2617

4-(4-Aminophenoxy)-N-methylpicolinamide

CAS: 284462-37-9

Formula: C₁₃H₁₃N₃O₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 243.266

Ref: 10-F077869

2-Pyridinecarboxamide, 4-(4-aminophenoxy)-N-methyl-

CAS: 284462-37-9

Formula: C₁₃H₁₃N₃O₂

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 243.2612

Ref: IN-DA00I5C4

Sorafenib EP Impurity A

CAS: 284462-37-9

Formula: C₁₃H₁₃N₃O₂

Colore e forma: Grey Solid

Peso molecolare: 243.27

Ref: 4Z-S-2732

4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide

CAS: 284462-37-9

4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide

Purezza: 98%

Colore e forma: Powder

Peso molecolare: 243.26g/mol

Ref: 54-OR303782

[4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide

Prodotto controllato

CAS: 284462-37-9

Formula: C₁₃H₁₃N₃O₂

Colore e forma: Light Brown

Peso molecolare: 243.26

Ref: TR-A618940

[4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide-d4

Prodotto controllato

CAS: 284462-37-9

Applications [4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide-d4 is an intermediate in the synthesis of Sorafenib-d4 (S676853); a labelled version of Sorafenib (S676850), a potent RAF kinase inhibitor.
References Richly, H., et al.: Int. J. Clin. Pharmacol. Ther., 41, 620 (2003);Khire, U.R., et al.: Bioorg. Med. Chem. Lett., 14, 783 (2004);Wilhelm, S.M., et al.: Cancer Res., 64, 7099 (2004);Rini, B.I., et al.: Expert Opin. Pharmacother., 7, 453 (2006)

Formula: C₁₃D₄H₉N₃O₂

Colore e forma: Neat

Peso molecolare: 247.286

Ref: TR-A618944

[4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide

CAS: 284462-37-9

4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide is a chemical compound that inhibits the growth of cancer cells by binding to the active site of b-raf and blocking its activity. It has been shown in a pharmacokinetics study that 4-(4-aminophenoxy)(2-pyridyl)]-N-methylcarboxamide is absorbed rapidly through the oral administration, excreted in urine, and eliminated rapidly from the body. The optimal reaction for this drug was found to be at pH 7.0 with an ionic strength of 0.1 M (sodium chloride). This drug also has significant inhibitory activities against human cervical carcinoma and breast cancer cell lines (MDA-MB-231).

Formula: C₁₃H₁₃N₃O₂

Purezza: Min. 95%

Colore e forma: Off-White To Beige To Light Brown Solid

Peso molecolare: 243.26 g/mol

Ref: 3D-FA17813

Sorafenib EP Impurity A

CAS: 284462-37-9

Formula: C₁₃H₁₃N₃O₂

Peso molecolare: 243.27

Ref: ST-EA-CP-S16001