CAS 287714-41-4

Rosuvastatina

Descrizione:

Rosuvastatina è un agente sintetico riduttore dei lipidi appartenente alla classe delle statine, utilizzato principalmente per gestire l'iperlipidemia e ridurre il rischio di malattie cardiovascolari. La sua formula chimica è C22H28FN3O6S e presenta una struttura distintiva che include un gruppo fluorofenile e un moiety di sulfonamide, contribuendo alla sua potenza. Rosuvastatina agisce inibendo la HMG-CoA reduttasi, un enzima cruciale per la biosintesi del colesterolo nel fegato, abbassando così i livelli di colesterolo LDL (lipoproteine a bassa densità) e trigliceridi, mentre aumenta il colesterolo HDL (lipoproteine ad alta densità). Il farmaco è caratterizzato da un'alta biodisponibilità e una lunga emivita, consentendo una somministrazione una volta al giorno. È generalmente ben tollerato, sebbene gli effetti collaterali potenziali possano includere dolore muscolare, elevazioni degli enzimi epatici e disturbi gastrointestinali. Rosuvastatina è spesso prescritto insieme a modifiche dello stile di vita, come dieta ed esercizio, per migliorare i suoi effetti riduttori del colesterolo. Il suo profilo di efficacia e sicurezza lo rende un farmaco ampiamente utilizzato nella gestione della dislipidemia.

Formula: C₂₂H₂₄D₃FN₃NaO₆S

InChI: InChI=1/C22H28FN3O6S/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32/h5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30)/b10-9+/t16-,17+/m0/s1

InChI key: InChIKey=BPRHUIZQVSMCRT-VEUZHWNKSA-N

SMILES: C(=C/[C@H](C[C@H](CC(O)=O)O)O)\C=1C(=NC(N(S(C)(=O)=O)C)=NC1C(C)C)C2=CC=C(F)C=C2

Sinonimi:

• (3R,5R,6E)-7-{4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid
• (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid
• (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoic acid
• (E)-(3R,5S)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methylsulfonyl)(methyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
• 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)-
• 7-[4-(4-Fluorophenyl)-6-(1-Methylethyl)-2-(Methyl-Methylsulfonyl-Amino)-Pyrimidin-5-Yl]-3,5-Dihydroxy-Hept-6-Enoic Acid
• Azd 4522
• Azd4522
• Rosuvastatin Acid
• Rosuvastatin intermediates
• X-Plended
• Zd 4522
• Rosuvastatin

Rosuvastatin Calcium

CAS: 147098-20-2, 287714-41-4

Formula: C₄₄H₅₄CaF₂N₆O₁₂S₂

Purezza: >95.0%(HPLC)(N)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 1,001.14

Ref: 3B-R0180

6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)-

CAS: 287714-41-4

Formula: C₂₂H₂₈FN₃O₆S

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 481.5376

Ref: IN-DA002WF6

Rosuvastatin-d3 sodium salt

CAS: 287714-41-4

Formula: C₂₂H₂₄D₃FN₃O₆S·Na

Colore e forma: Yellow Solid

Peso molecolare: 483.56 22.99

Ref: 4Z-R-092

Rosuvastatin

CAS: 287714-41-4

Rosuvastatin

Purezza: ≥95%

Peso molecolare: 481.54g/mol

Ref: 54-BUP06104

Rosuvastatin-d4 sodium salt

CAS: 287714-41-4

Formula: C₂₂H₂₃D₄FN₃O₆S·Na

Peso molecolare: 484.56 22.99

Ref: 4Z-R-093

Rosuvastatin EP Impurity I Calcium Salt

CAS: 287714-41-4

Formula: C₂₂H₂₇FN₃O₆SCa

Peso molecolare: 480.54 1/2 40.08

Ref: 4Z-R-0934

Rosuvastatin

CAS: 287714-41-4

Rosuvastatin (ZD4522) is an inhibitor of HMG-CoA reductase (HMGCR). Rosuvastatin has hypolipidemic and antiatherosclerotic effects. Cost-effective and quality-assured.

Formula: C₂₂H₂₈FN₃O₆S

Purezza: 95.24% - 99.8%

Colore e forma: Solid

Peso molecolare: 481.54

Ref: TM-T1676

rac-Rosuvastatin Sodium Salt (Mixture: R700515 and Sodium Salt of R700500)

Prodotto controllato

CAS: 287714-41-4

Formula: C₂₂H₂₇FN₃NaO₆S

Colore e forma: Neat

Peso molecolare: 503.519

Ref: TR-R700720

rac-Rosuvastatin Sodium Salt (E/Z Mixture)

Prodotto controllato

CAS: 1007871-86-4, 287714-41-4

Formula: C₂₂H₂₇FN₃NaO₆S

Colore e forma: Neat

Peso molecolare: 503.52

Ref: TR-R700725

7,8-Dihydro-rosuvastatin Diisopropylammonium Salt

Prodotto controllato

CAS: 287714-41-4

Formula: C₂₈H₄₅FN₄O₆S

Colore e forma: Neat

Peso molecolare: 584.74

Ref: TR-D450540

N-Desmethyl N-ethyl Rosuvastatin Sodium Salt

Prodotto controllato

CAS: 287714-41-4

Formula: C₂₃H₂₉FN₃NaO₆S

Colore e forma: Neat

Peso molecolare: 517.546

Ref: TR-D292395

(3S,5R)-5-((R)-8-fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt

Prodotto controllato

CAS: 287714-41-4

Formula: C₂₂H₂₇FN₃NaO₆S

Colore e forma: Neat

Peso molecolare: 503.519

Ref: TR-F592045

(3S,5S)-5-((S)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt

Prodotto controllato

CAS: 287714-41-4

Applications (3S,5S)-5-((S)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt is an impurity of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.
References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997); Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005); Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006)

Formula: C₂₂H₂₇FN₃NaO₆S

Colore e forma: Neat

Peso molecolare: 503.519

Ref: TR-F592055

(3S,5S)-5-((R)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt

Prodotto controllato

CAS: 287714-41-4

Applications (3S,5S)-5-((R)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl)-3,5-dihydroxypentanoate Sodium Salt is an impurity of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.
References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997); Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005); Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006)

Formula: C₂₂H₂₇FN₃NaO₆S

Colore e forma: Neat

Peso molecolare: 503.519

Ref: TR-F592040

Rosuvastatin

CAS: 287714-41-4

Rosuvastatin is a synthetic lipid-lowering agent, which is a product of pharmaceutical manufacturing derived from extensive research in cardiovascular pharmacology. It functions as an HMG-CoA reductase inhibitor, effectively blocking the enzyme responsible for cholesterol biosynthesis in the liver. By inhibiting this enzyme, Rosuvastatin reduces the production of cholesterol, especially low-density lipoprotein (LDL) cholesterol, which is known to contribute to atherosclerosis.

Formula: C₂₂H₂₈FN₃O₆S

Purezza: Min. 95%

Peso molecolare: 481.54 g/mol

Ref: 3D-FF139301